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Your search keyword '"Rönnelid, Johan"' showing total 11 results
Start Over Author "Rönnelid, Johan" Journal frontiers in immunology
11 results on '"Rönnelid, Johan"'

1. Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Author

Sherina, Natalia, primary, de Vries, Charlotte, additional, Kharlamova, Nastya, additional, Sippl, Natalie, additional, Jiang, Xia, additional, Brynedal, Boel, additional, Kindstedt, Elin, additional, Hansson, Monika, additional, Mathsson-Alm, Linda, additional, Israelsson, Lena, additional, Stålesen, Ragnhild, additional, Saevarsdottir, Saedis, additional, Holmdahl, Rikard, additional, Hensvold, Aase, additional, Johannsen, Gunnar, additional, Eriksson, Kaja, additional, Sallusto, Federica, additional, Catrina, Anca I., additional, Rönnelid, Johan, additional, Grönwall, Caroline, additional, Yucel-Lindberg, Tülay, additional, Alfredsson, Lars, additional, Klareskog, Lars, additional, Piccoli, Luca, additional, Malmström, Vivianne, additional, Amara, Khaled, additional, and Lundberg, Karin, additional

Published
2022
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2. A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Author

Grönwall, Caroline, primary, Liljefors, Lisa, additional, Bang, Holger, additional, Hensvold, Aase H., additional, Hansson, Monika, additional, Mathsson-Alm, Linda, additional, Israelsson, Lena, additional, Joshua, Vijay, additional, Svärd, Anna, additional, Stålesen, Ragnhild, additional, Titcombe, Philip J., additional, Steen, Johanna, additional, Piccoli, Luca, additional, Sherina, Natalia, additional, Clavel, Cyril, additional, Svenungsson, Elisabet, additional, Gunnarsson, Iva, additional, Saevarsdottir, Saedis, additional, Kastbom, Alf, additional, Serre, Guy, additional, Alfredsson, Lars, additional, Malmström, Vivianne, additional, Rönnelid, Johan, additional, Catrina, Anca I., additional, Lundberg, Karin, additional, and Klareskog, Lars, additional

Published
2021
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4. False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases

Author

Kharlamova, Nastya, primary, Dunn, Nicky, additional, Bedri, Sahl K., additional, Jerling, Svante, additional, Almgren, Malin, additional, Faustini, Francesca, additional, Gunnarsson, Iva, additional, Rönnelid, Johan, additional, Pullerits, Rille, additional, Gjertsson, Inger, additional, Lundberg, Karin, additional, Månberg, Anna, additional, Pin, Elisa, additional, Nilsson, Peter, additional, Hober, Sophia, additional, Fink, Katharina, additional, and Fogdell-Hahn, Anna, additional

Published
2021
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5. A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Author

Grönwall, Caroline, Liljefors, Lisa, Bang, Holger, Hensvold, Aase H., Hansson, Monika, Mathsson-Alm, Linda, Israelsson, Lena, Joshua, Vijay, Svärd, Anna, Stålesen, Ragnhild, Titcombe, Philip J., Steen, Johanna, Piccoli, Luca, Sherina, Natalia, Clavel, Cyril, Svenungsson, Elisabet, Gunnarsson, Iva, Saevarsdottir, Saedis, Kastbom, Alf, Serre, Guy, Alfredsson, Lars, Malmström, Vivianne, Rönnelid, Johan, Catrina, Anca I., Lundberg, Karin, and Klareskog, Lars

Subjects
musculoskeletal diseases, Adult, Male, rheumatoid arthritis, autoantibodies, Immunology, Autoimmunity, Autoantigens, Peptides, Cyclic, Anti-Citrullinated Protein Antibodies, Arthritis, Rheumatoid, anti-CCP antibodies, Antibody Specificity, anti-carbamylated protein antibodies, Malondialdehyde, Humans, Rheumatology and Autoimmunity, Aged, Original Research, Reumatologi och inflammation, Protein Carbamylation, Immunology in the medical area, Acetylation, Middle Aged, Immunoglobulin A, anti-citrullinated protein antibodies (ACPAs), anti-acetylated protein antibodies, Immunologi inom det medicinska området, Case-Control Studies, Immunoglobulin G, Female, Protein Processing, Post-Translational, anti-modified protein antibodies
Abstract

Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. anti-carbamylated (Carb), -acetylated (KAc), and malondialdehyde acetaldehyde (MAA) modified protein antibodies, have been described. In this comprehensive study, we analyze 30 different IgG and IgA AMPA reactivities to Cit, Carb, KAc, and MAA antigens detected by ELISA and autoantigen arrays in N=1985 newly diagnosed RA patients. Association with patient characteristics such as smoking and disease activity were explored. Carb and KAc reactivities by different assays were primarily seen in patients also positive for anti-citrulline reactivity. Modified vimentin (mod-Vim) peptides were used for direct comparison of different AMPA reactivities, revealing that IgA AMPA recognizing mod-Vim was mainly detected in subsets of patients with high IgG anti-Cit-Vim levels and a history of smoking. IgG reactivity to acetylation was mainly detected in a subset of patients with Cit and Carb reactivity. Anti-acetylated histone reactivity was RA-specific and associated with high anti-CCP2 IgG levels, multiple ACPA fine-specificities, and smoking status. This reactivity was also found to be present in CCP2+ RA-risk individuals without arthritis. Our data further demonstrate that IgG autoreactivity to MAA was increased in RA compared to controls with highest levels in CCP2+ RA, but was not RA-specific, and showed low correlation with other AMPA. Anti-MAA was instead associated with disease activity and was not significantly increased in CCP2+ individuals at risk of RA. Notably, RA patients could be subdivided into four different subsets based on their AMPA IgG and IgA reactivity profiles. Our serology results were complemented by screening of monoclonal antibodies derived from single B cells from RA patients for the same antigens as the RA cohort. Certain CCP2+ clones had Carb or Carb+KAc+ multireactivity, while such reactivities were not found in CCP2- clones. We conclude that autoantibodies exhibiting different patterns of ACPA fine-specificities as well as Carb and KAc reactivity are present in RA and may be derived from multireactive B-cell clones. Carb and KAc could be considered reactivities within the "Cit-umbrella" similar to ACPA fine-specificities, while MAA reactivity is distinctly different.

Published
2020

6. Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients

Author

Idborg, Helena, primary, Zandian, Arash, additional, Ossipova, Elena, additional, Wigren, Edvard, additional, Preger, Charlotta, additional, Mobarrez, Fariborz, additional, Checa, Antonio, additional, Sohrabian, Azita, additional, Pucholt, Pascal, additional, Sandling, Johanna K., additional, Fernandes-Cerqueira, Cátia, additional, Rönnelid, Johan, additional, Oke, Vilija, additional, Grosso, Giorgia, additional, Kvarnström, Marika, additional, Larsson, Anders, additional, Wheelock, Craig E., additional, Syvänen, Ann-Christine, additional, Rönnblom, Lars, additional, Kultima, Kim, additional, Persson, Helena, additional, Gräslund, Susanne, additional, Gunnarsson, Iva, additional, Nilsson, Peter, additional, Svenungsson, Elisabet, additional, and Jakobsson, Per-Johan, additional

Published
2019
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7. Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Author

Lloyd, Katy A., primary, Wigerblad, Gustaf, additional, Sahlström, Peter, additional, Garimella, Manasa G., additional, Chemin, Karine, additional, Steen, Johanna, additional, Titcombe, Philip J., additional, Marklein, Bianka, additional, Zhou, Diana, additional, Stålesen, Ragnhild, additional, Ossipova, Elena, additional, Lundqvist, Christina, additional, Ekwall, Olov, additional, Rönnelid, Johan, additional, Mueller, Daniel L., additional, Karlsson, Mikael C. I., additional, Kaplan, Mariana J., additional, Skriner, Karl, additional, Klareskog, Lars, additional, Wermeling, Fredrik, additional, Malmström, Vivianne, additional, and Grönwall, Caroline, additional

Published
2019
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8. Corrigendum: Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

Author

Gerstner, Christina, primary, Dubnovitsky, Anatoly, additional, Sandin, Charlotta, additional, Kozhukh, Genadiy, additional, Uchtenhagen, Hannes, additional, James, Eddie A., additional, Rönnelid, Johan, additional, Ytterberg, Anders Jimmy, additional, Pieper, Jennifer, additional, Reed, Evan, additional, Tandre, Karolina, additional, Rieck, Mary, additional, Zubarev, Roman A., additional, Rönnblom, Lars, additional, Sandalova, Tatyana, additional, Buckner, Jane H., additional, Achour, Adnane, additional, and Malmström, Vivianne, additional

Published
2017
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9. Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

Author

Gerstner, Christina, primary, Dubnovitsky, Anatoly, additional, Sandin, Charlotta, additional, Kozhukh, Genadiy, additional, Uchtenhagen, Hannes, additional, James, Eddie A., additional, Rönnelid, Johan, additional, Ytterberg, Anders Jimmy, additional, Pieper, Jennifer, additional, Reed, Evan, additional, Tandre, Karolina, additional, Rieck, Mary, additional, Zubarev, Roman A., additional, Rönnblom, Lars, additional, Sandalova, Tatyana, additional, Buckner, Jane H., additional, Achour, Adnane, additional, and Malmström, Vivianne, additional

Published
2016
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11. Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Author

Sherina, Natalia, de Vries, Charlotte, Kharlamova, Nastya, Sippl, Natalie, Jiang, Xia, Brynedal, Boel, Kindstedt, Elin, Hansson, Monika, Mathsson-Alm, Linda, Israelsson, Lena, Stålesen, Ragnhild, Saevarsdottir, Saedis, Holmdahl, Rikard, Hensvold, Aase, Johannsen, Gunnar, Eriksson, Kaja, Sallusto, Federica, Catrina, Anca I., Rönnelid, Johan, Grönwall, Caroline, Yucel-Lindberg, Tülay, Alfredsson, Lars, Klareskog, Lars, Piccoli, Luca, Malmström, Vivianne, Amara, Khaled, and Lundberg, Karin

Subjects
periodontitis (PD), B cells, Reumatologi och inflammation, Rheumatoid arthritis (RA), Immunologi inom det medicinska området, anti-citrullinated protein antibodies (ACPA), Immunology in the medical area, Porphyromonas gingivalis (Pg), monoclonal antibodies (mAbs), rheumatoid arthritis (RA), Rheumatology and Autoimmunity
Abstract

Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated protein antibodies (ACPA), which are present in a majority of RA patients, may be triggered in the gum mucosa. To address this hypothesis, we investigated the antibody response to a citrullinated P. gingivalis peptide in relation to the autoimmune ACPA response in early RA, and examined citrulline-reactivity in monoclonal antibodies derived from human gingival B cells. Antibodies to a citrullinated peptide derived from P. gingivalis (denoted CPP3) and human citrullinated peptides were analyzed by multiplex array in 2,807 RA patients and 372 controls; associations with RA risk factors and clinical features were examined. B cells from inflamed gingival tissue were single-cell sorted, and immunoglobulin (Ig) genes were amplified, sequenced, cloned and expressed (n=63) as recombinant monoclonal antibodies, and assayed for citrulline-reactivities by enzyme-linked immunosorbent assay. Additionally, affinity-purified polyclonal anti-cyclic-citrullinated peptide (CCP2) IgG, and monoclonal antibodies derived from RA blood and synovial fluid B cells (n=175), were screened for CPP3-reactivity. Elevated anti-CPP3 antibody levels were detected in RA (11%), mainly CCP2+ RA, compared to controls (2%), p, Frontiers in Immunology, 13, ISSN:1664-3224

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