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Start Over Author "Schetelig, Johannes" Journal frontiers in immunology
9 results on '"Schetelig, Johannes"'

1. Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight

Author

Schetelig, Johannes, primary, Baldauf, Henning, additional, Heidenreich, Falk, additional, Hoogenboom, Jorinde D., additional, Spellman, Stephen R., additional, Kulagin, Alexander, additional, Schroeder, Thomas, additional, Sengeloev, Henrik, additional, Dreger, Peter, additional, Forcade, Edouard, additional, Vydra, Jan, additional, Wagner-Drouet, Eva Maria, additional, Choi, Goda, additional, Paneesha, Shankara, additional, Miranda, Nuno A. A., additional, Tanase, Alina, additional, de Wreede, Liesbeth C., additional, Lange, Vinzenz, additional, Schmidt, Alexander H., additional, Sauter, Jürgen, additional, Fein, Joshua A., additional, Bolon, Yung-Tsi, additional, He, Meilun, additional, Marsh, Steven G. E., additional, Gadalla, Shahinaz M., additional, Paczesny, Sophie, additional, Ruggeri, Annalisa, additional, Chabannon, Christian, additional, and Fleischhauer, Katharina, additional

Published
2024
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2. Donor selection for KIR alloreactivity is associated with superior survival in haploidentical transplant with PTCy

Author

Zou, Jun, primary, Kongtim, Piyanuch, additional, Srour, Samer A., additional, Greenbaum, Uri, additional, Schetelig, Johannes, additional, Heidenreich, Falk, additional, Baldauf, Henning, additional, Moore, Brandt, additional, Saengboon, Supawee, additional, Carmazzi, Yudith, additional, Rondon, Gabriela, additional, Ma, Qing, additional, Rezvani, Katayoun, additional, Shpall, Elizabeth J., additional, Champlin, Richard E., additional, Ciurea, Stefan O., additional, and Cao, Kai, additional

Published
2022
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3. Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft-versus-host-disease

Author

Krüger, Thomas, primary, Wehner, Rebekka, additional, Herbig, Maik, additional, Kräter, Martin, additional, Kramer, Michael, additional, Middeke, Jan Moritz, additional, Stölzel, Friedrich, additional, List, Catrin, additional, Egger-Heidrich, Katharina, additional, Teipel, Raphael, additional, Oelschlägel, Uta, additional, Wermke, Martin, additional, Jambor, Helena, additional, Wobus, Manja, additional, Schetelig, Johannes, additional, Jöhrens, Korinna, additional, Tonn, Torsten, additional, Subburayalu, Julien, additional, Schmitz, Marc, additional, Bornhauser, Martin, additional, and von Bonin, Malte, additional

Published
2022
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4. Corrigendum: Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia

Author

Schetelig, Johannes, primary, Baldauf, Henning, additional, Koster, Linda, additional, Kuxhausen, Michelle, additional, Heidenreich, Falk, additional, de Wreede, Liesbeth C., additional, Spellman, Stephen, additional, van Gelder, Michel, additional, Bruno, Benedetto, additional, Onida, Francesco, additional, Lange, Vinzenz, additional, Massalski, Carolin, additional, Potter, Victoria, additional, Ljungman, Per, additional, Schaap, Nicolaas, additional, Hayden, Patrick, additional, Lee, Stephanie J., additional, Kröger, Nicolaus, additional, Hsu, Kathy, additional, Schmidt, Alexander H., additional, Yakoub-Agha, Ibrahim, additional, and Robin, Marie, additional

Published
2021
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5. Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity

Author

Schetelig, Johannes, Heidenreich, Falk, Baldauf, Henning, Trost, Sarah, Falk, Bose, Hoßbach, Christian, Real, Ruben, Roers, Axel, Lindemann, Dirk, Dalpke, Alexander, Kolditz, Martin, de With, Katja, Bornhäuser, Martin, Bonifacio, Ezio E., Rücker-Braun, Elke, Lange, Vinzenz, Markert, Jan, Barth, Ralf, Hofmann, Jan A., Sauter, Jürgen, Bernas, Stefanie N., and Schmidt, Alexander H.

Subjects
Adult, Male, Genotype, in silico prediction, SARS-CoV-2, Histocompatibility Antigens Class I, Immunology, T-cell epitopes, Histocompatibility Antigens Class II, Epitopes, T-Lymphocyte, Middle Aged, HLA, immunogenetics, Cross-Sectional Studies, Spike Glycoprotein, Coronavirus, Humans, Immunology and Allergy, Computer Simulation, Female, Coronavirus Infections, Original Research
Abstract

HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data from 6,919 infected individuals. HLA-A, -B, and -DRB1 allotypes grouped into HLA supertypes by functional or predicted structural similarities of the peptide-binding grooves did not predict COVID-19 severity. Further, we did not observe a heterozygote advantage or a benefit from HLA diplotypes with more divergent physicochemical peptide-binding properties. Finally, numbers of in silico predicted viral T-cell epitopes did not correlate with the severity of SARS-CoV-2 infections. These findings suggest that the HLA genotype is no major factor determining COVID-19 severity. Moreover, our data suggest that the spike glycoprotein alone may allow for abundant T-cell epitopes to mount robust T-cell responses not limited by the HLA genotype.

Published
2021
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6. Donor selection for KIR alloreactivity is associated with superior survival in haploidentical transplant with PTCy.

Author

Jun Zou, Piyanuch Kongtim, Srour, Samer A., Greenbaum, Uri, Schetelig, Johannes, Heidenreich, Falk, Baldauf, Henning, Moore, Brandt, Saengboon, Supawee, Carmazzi, Yudith, Rondon, Gabriela, Qing Ma, Katayoun Rezvani, Shpall, Elizabeth J., Champlin, Richard E., Ciurea, Stefan O., and Kai Cao

Subjects
HEMATOPOIETIC stem cell transplantation, STEM cell transplantation, KILLER cell receptors, TRANSPLANTATION of organs, tissues, etc., REGRESSION trees, REGRESSION analysis, OVERALL survival
Abstract

With the continuous increase in the use of haploidentical donors for transplantation, the selection of donors becomes increasingly important. Haploidentical donors have been selected primarily based on clinical characteristics, while the effects of killer cell immunoglobulin-like receptors (KIRs) on outcomes of haploidentical-hematopoietic stem cell transplantation (haplo-HSCT) with post-transplant cyclophosphamide (PTCy) remain inconclusive. The present study aimed to thoroughly evaluate the effect of KIRs and binding ligands assessed by various models, in addition to other patient/donor variables, on clinical outcomes in haplo-HSCT. In a cohort of 354 patients undergoing their first haplo-HSCT, we found that a higher Count Functional inhibitory KIR score (CF-iKIR) was associated with improved progression-free survival (adjusted hazard ratio [HR], 0.71; P = .029) and overall survival (OS) (HR, 0.66; P = .016), while none of the other models predicted for survival in these patients. Moreover, using exploratory classification and regression tree analysis, we found that donor age <58 years combined with cytomegalovirus-nonreactive recipient was associated with the best OS, whereas donor age >58 years was associated with the worst OS. In the rest of our cohort (80%), cytomegalovirus-reactive recipients with a donor <58 years old, a higher CF-iKIR was associated with superior OS. The 3-year OS rates were 73.9%, 54.1% (HR, 1.84; P = .044), 44.5% (HR, 2.01; P = .003), and 18.5% (HR, 5.44; P <.001) in the best, better, poor, and worse donor groups, respectively. Our results suggest that KIR alloreactivity assessed by CF-iKIR score can help optimize donor selection in haplo-HSCT. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia

Author

Schetelig, Johannes, primary, Baldauf, Henning, additional, Koster, Linda, additional, Kuxhausen, Michelle, additional, Heidenreich, Falk, additional, de Wreede, Liesbeth C., additional, Spellman, Stephen, additional, van Gelder, Michel, additional, Bruno, Benedetto, additional, Onida, Francesco, additional, Lange, Vinzenz, additional, Massalski, Carolin, additional, Potter, Victoria, additional, Ljungman, Per, additional, Schaap, Nicolaas, additional, Hayden, Patrick, additional, Lee, Stephanie J., additional, Kröger, Nicolaus, additional, Hsu, Kathy, additional, Schmidt, Alexander H., additional, Yakoub-Agha, Ibrahim, additional, and Robin, Marie, additional

Published
2021
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8. Estimation of German KIR Allele Group Haplotype Frequencies

Author

Solloch, Ute V., primary, Schefzyk, Daniel, additional, Schäfer, Gesine, additional, Massalski, Carolin, additional, Kohler, Maja, additional, Pruschke, Jens, additional, Heidl, Annett, additional, Schetelig, Johannes, additional, Schmidt, Alexander H., additional, Lange, Vinzenz, additional, and Sauter, Jürgen, additional

Published
2020
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9. Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

Author

Wagner, Ines, primary, Schefzyk, Daniel, additional, Pruschke, Jens, additional, Schöfl, Gerhard, additional, Schöne, Bianca, additional, Gruber, Nicole, additional, Lang, Kathrin, additional, Hofmann, Jan, additional, Gnahm, Christine, additional, Heyn, Bianca, additional, Marin, Wesley M., additional, Dandekar, Ravi, additional, Hollenbach, Jill A., additional, Schetelig, Johannes, additional, Pingel, Julia, additional, Norman, Paul J., additional, Sauter, Jürgen, additional, Schmidt, Alexander H., additional, and Lange, Vinzenz, additional

Published
2018
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