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Your search keyword '"van Balen, Peter"' showing total 9 results
Start Over "van Balen, Peter" Journal frontiers in immunology
9 results on '"van Balen, Peter"'

1. Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation

Author

Koster, Eva A. S., primary, von dem Borne, Peter A., additional, van Balen, Peter, additional, Marijt, Erik W. A., additional, Tjon, Jennifer M. L., additional, Snijders, Tjeerd J. F., additional, van Lammeren, Daniëlle, additional, Veelken, Hendrik, additional, Falkenburg, J. H. Frederik, additional, Halkes, Constantijn J. M., additional, and de Wreede, Liesbeth C., additional

Published
2024
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2. Joint models quantify associations between immune cell kinetics and allo-immunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion

Author

Koster, Eva A. S., primary, Bonneville, Edouard F., additional, Borne, Peter A. von dem, additional, van Balen, Peter, additional, Marijt, Erik W. A., additional, Tjon, Jennifer M. L., additional, Snijders, Tjeerd J. F., additional, van Lammeren, Daniëlle, additional, Veelken, Hendrik, additional, Putter, Hein, additional, Falkenburg, J. H. Frederik, additional, Halkes, Constantijn J. M., additional, and de Wreede, Liesbeth C., additional

Published
2023
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3. Joint models quantify associations between immune cell kinetics and alloimmunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion.

Author

Koster, Eva A. S., Bonneville, Edouard F., von dem Borne, Peter A., van Balen, Peter, Marijt, Erik W. A., Tjon, Jennifer M. L., Snijders, Tjeerd J. F., van Lammeren, Daniëlle, Veelken, Hendrik, Putter, Hein, Falkenburg, J. H. Frederik, Halkes, Constantijn J. M., and de Wreede, Liesbeth C.

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, KILLER cells, LYMPHOCYTES
Abstract

Alloreactive donor-derived T-cells play a pivotal role in alloimmune responses after allogeneic hematopoietic stem cell transplantation (alloSCT); both in the relapse-preventing Graft-versus-Leukemia (GvL) effect and the potentially lethal complication Graft-versus-Host-Disease (GvHD). The balance between GvL and GvHD can be shifted by removing T-cells via T-cell depletion (TCD) to reduce the risk of GvHD, and by introducing additional donor T-cells (donor lymphocyte infusions [DLI]) to boost the GvL effect. However, the association between T-cell kinetics and the occurrence of allo-immunological events has not been clearly demonstrated yet. Therefore, we investigated the complex associations between the T-cell kinetics and alloimmune responses in a cohort of 166 acute leukemia patients receiving alemtuzumab-based TCD alloSCT. Of these patients, 62 with an anticipated high risk of relapse were scheduled to receive a prophylactic DLI at 3 months after transplant. In this setting, we applied joint modelling which allowed us to better capture the complex interplay between DLI, T-cell kinetics, GvHD and relapse than traditional statistical methods. We demonstrate that DLI can induce detectable T-cell expansion, leading to an increase in total, CD4+ and CD8+ T-cell counts starting at 3 months after alloSCT. CD4+ T-cells showed the strongest association with the development of alloimmune responses: higher CD4 counts increased the risk of GvHD (hazard ratio 2.44, 95% confidence interval 1.45-4.12) and decreased the risk of relapse (hazard ratio 0.65, 95% confidence interval 0.45-0.92). Similar models showed that natural killer cells recovered rapidly after alloSCT and were associated with a lower risk of relapse (HR 0.62, 95%-CI 0.41-0.93). The results of this study advocate the use of joint models to further study immune cell kinetics in different settings. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Promiscuity of Peptides Presented in HLA-DP Molecules from Different Immunogenicity Groups Is Associated With T-Cell Cross-Reactivity

Author

Laghmouchi, Aicha, primary, Kester, Michel G. D., additional, Hoogstraten, Conny, additional, Hageman, Lois, additional, de Klerk, Wendy, additional, Huisman, Wesley, additional, Koster, Eva A. S., additional, de Ru, Arnoud H., additional, van Balen, Peter, additional, Klobuch, Sebastian, additional, van Veelen, Peter A., additional, Falkenburg, J. H. Frederik, additional, and Jedema, Inge, additional

Published
2022
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5. HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

Author

van Balen, Peter, primary, Jedema, Inge, additional, van Loenen, Marleen M., additional, de Boer, Renate, additional, van Egmond, H. M., additional, Hagedoorn, Renate S., additional, Hoogstaten, Conny, additional, Veld, Sabrina A. J., additional, Hageman, Lois, additional, van Liempt, P. A. G., additional, Zwaginga, Jaap-Jan, additional, Meij, Pauline, additional, Veelken, H., additional, Falkenburg, J. H. F., additional, and Heemskerk, Mirjam H. M., additional

Published
2020
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6. CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

Author

van Balen, Peter, primary, van Bergen, Cornelis A. M., additional, van Luxemburg-Heijs, Simone A. P., additional, de Klerk, Wendy, additional, van Egmond, Esther H. M., additional, Veld, Sabrina A. J., additional, Halkes, Constantijn J. M., additional, Zwaginga, Jaap-Jan, additional, Griffioen, Marieke, additional, Jedema, Inge, additional, and Falkenburg, J. H. Frederik, additional

Published
2018
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7. Dissecting Genetic Control of HLA-DPB1 Expression and Its Relation to Structural Mismatch Models in Hematopoietic Stem Cell Transplantation

Author

Meurer, Thuja, primary, Arrieta-Bolaños, Esteban, additional, Metzing, Maximilian, additional, Langer, Mona-May, additional, van Balen, Peter, additional, Falkenburg, J. H. Frederik, additional, Beelen, Dietrich W., additional, Horn, Peter A., additional, Fleischhauer, Katharina, additional, and Crivello, Pietro, additional

Published
2018
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8. Tissue Damage Caused by Myeloablative, but Not Non-Myeloablative, Conditioning before Allogeneic Stem Cell Transplantation Results in Dermal Macrophage Recruitment without Active T-Cell Interaction

Author

van Balen, Peter, primary, van der Zouwen, Boris, additional, Kruisselbrink, Alwine B., additional, Eefting, Matthijs, additional, Szuhai, Karoly, additional, Jordanova, Ekaterina S., additional, Falkenburg, J. H. F., additional, and Jedema, Inge, additional

Published
2018
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9. Alloreactive T Cell Receptor Diversity against Structurally Similar or Dissimilar HLA-DP Antigens Assessed by Deep Sequencing

Author

Arrieta-Bolaños, Esteban, primary, Crivello, Pietro, additional, Metzing, Maximilian, additional, Meurer, Thuja, additional, Ahci, Müberra, additional, Rytlewski, Julie, additional, Vignali, Marissa, additional, Yusko, Erik, additional, van Balen, Peter, additional, Horn, Peter A., additional, Falkenburg, J. H. Frederik, additional, and Fleischhauer, Katharina, additional

Published
2018
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