1. Developing a New qFIBS Model Assessing Histological Features in Pediatric Patients With Non-alcoholic Steatohepatitis
- Author
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Feng Liu, Lai Wei, Wei Qiang Leow, Shu-Hong Liu, Ya-Yun Ren, Xiao-Xiao Wang, Xiao-He Li, Hui-Ying Rao, Rui Huang, Nan Wu, Aileen Wee, and Jing-Min Zhao
- Subjects
automated quantitative evaluation ,fibrosis ,inflammation ,ballooning ,steatosis ,liver ,Medicine (General) ,R5-920 - Abstract
BackgroundThe evolution of pediatric non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is associated with unique histological features. Pathological evaluation of liver specimen is often hindered by observer variability and diagnostic consensus is not always attainable. We investigated whether the qFIBS technique derived from adult NASH could be applied to pediatric NASH.Materials and Methods102 pediatric patients ( 0.85 (0.85–0.95)] and ability to distinguish different stages of fibrosis. qFIBS showed weak correlation with ballooning (r = 0.38, P = 0.028) and inflammation (r = 0.46, P = 0.005); however, it could distinguish different grades of ballooning (AUROCs 0.73, sensitivity 0.36, and specificity 0.92) and inflammation (AUROCs 0.77, sensitivity 0.83, and specificity 0.53).ConclusionIt was demonstrated that when qFIBS derived from adult NASH was performed on pediatric NASH, it could best distinguish the various histological grades of steatosis and fibrosis.
- Published
- 2022
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