1. Skin infiltrating T-cell profile of drug reaction with eosinophilia and systemic symptoms (DRESS) reactions among HIV-infected patients
- Author
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Tafadzwa Chimbetete, Phuti Choshi, Sarah Pedretti, Mireille Porter, Riyaadh Roberts, Rannakoe Lehloenya, and Jonathan Peter
- Subjects
drug reaction with eosinophilia and systemic symptoms ,human immunodeficiency virus ,immunohistochemistry ,severe cutaneous adverse reaction ,T-cell ,first-line tuberculosis drug ,Medicine (General) ,R5-920 - Abstract
IntroductionDrug Reaction with Eosinophilia Systemic Symptoms (DRESS) is more common in persons living with HIV (PLHIV), and first-line anti-TB drugs (FLTDs) and cotrimoxazole are the commonest offending drugs. Limited data is available on the skin infiltrating T-cell profile among DRESS patients with systemic CD4 T-cell depletion associated with HIV.Materials and methodsHIV cases with validated DRESS phenotypes (possible, probable, or definite) and confirmed reactions to either one or multiple FLTDs and/or cotrimoxazole were chosen (n = 14). These cases were matched against controls of HIV-negative patients who developed DRESS (n = 5). Immunohistochemistry assays were carried out with the following antibodies: CD3, CD4, CD8, CD45RO and FoxP3. Positive cells were normalized to the number of CD3+ cells present.ResultsSkin infiltrating T-cells were mainly found in the dermis. Dermal and epidermal CD4+ T-cells (and CD4+/CD8+ ratios) were lower in HIV-positive vs. negative DRESS; p
- Published
- 2023
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