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Your search keyword '"Jan, Gwénaël"' showing total 11 results
Start Over Author "Jan, Gwénaël" Journal frontiers in microbiology
11 results on '"Jan, Gwénaël"'

1. Therapeutic Effects of Probiotic Minas Frescal Cheese on the Attenuation of Ulcerative Colitis in a Murine Model

Author

Cordeiro, Bárbara F., primary, Alves, Juliana L., additional, Belo, Giovanna A., additional, Oliveira, Emiliano R., additional, Braga, Marina P., additional, da Silva, Sara H., additional, Lemos, Luisa, additional, Guimarães, Jonas T., additional, Silva, Ramon, additional, Rocha, Ramon S., additional, Jan, Gwénaël, additional, Le Loir, Yves, additional, Silva, Marcia Cristina, additional, Freitas, Mônica Q., additional, Esmerino, Erick A., additional, Gala-García, Alfonso, additional, Ferreira, Enio, additional, Faria, Ana Maria C., additional, Cruz, Adriano G., additional, Azevedo, Vasco, additional, and do Carmo, Fillipe L. R., additional

Published
2021
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2. Differential Adaptation of Propionibacterium freudenreichii CIRM-BIA129 to Cow’s Milk Versus Soymilk Environments Modulates Its Stress Tolerance and Proteome

Author

Tarnaud, Florian, primary, Gaucher, Floriane, additional, do Carmo, Fillipe Luiz Rosa, additional, Illikoud, Nassima, additional, Jardin, Julien, additional, Briard-Bion, Valérie, additional, Guyomarc’h, Fanny, additional, Gagnaire, Valérie, additional, and Jan, Gwénaël, additional

Published
2020
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3. Propionibacterium freudenreichii CIRM-BIA 129 Osmoadaptation Coupled to Acid-Adaptation Increases Its Viability During Freeze-Drying

Author

Gaucher, Floriane, primary, Kponouglo, Koffigan, additional, Rabah, Houem, additional, Bonnassie, Sylvie, additional, Ossemond, Jordane, additional, Pottier, Sandrine, additional, Jardin, Julien, additional, Briard-Bion, Valérie, additional, Marchand, Pierre, additional, Blanc, Philippe, additional, Jeantet, Romain, additional, and Jan, Gwénaël, additional

Published
2019
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7. Whey Protein Isolate-Supplemented Beverage, Fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the Prevention of Mucositis in Mice

Author

Cordeiro, Bárbara F., primary, Oliveira, Emiliano R., additional, da Silva, Sara H., additional, Savassi, Bruna M., additional, Acurcio, Leonardo B., additional, Lemos, Luisa, additional, Alves, Juliana de L., additional, Carvalho Assis, Helder, additional, Vieira, Angélica T., additional, Faria, Ana M. C., additional, Ferreira, Enio, additional, Le Loir, Yves, additional, Jan, Gwénaël, additional, Goulart, Luiz R., additional, Azevedo, Vasco, additional, Carvalho, Rodrigo D. de O., additional, and do Carmo, Fillipe L. R., additional

Published
2018
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8. Mutation of the Surface Layer Protein SlpB Has Pleiotropic Effects in the Probiotic Propionibacterium freudenreichii CIRM-BIA 129

Author

do Carmo, Fillipe L. R., primary, Silva, Wanderson M., additional, Tavares, Guilherme C., additional, Ibraim, Izabela C., additional, Cordeiro, Barbara F., additional, Oliveira, Emiliano R., additional, Rabah, Houem, additional, Cauty, Chantal, additional, da Silva, Sara H., additional, Canário Viana, Marcus V., additional, Caetano, Ana C. B., additional, dos Santos, Roselane G., additional, de Oliveira Carvalho, Rodrigo D., additional, Jardin, Julien, additional, Pereira, Felipe L., additional, Folador, Edson L., additional, Le Loir, Yves, additional, Figueiredo, Henrique C. P., additional, Jan, Gwénaël, additional, and Azevedo, Vasco, additional

Published
2018
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11. Recombinant probiotic Lactococcus lactis delivering P62 mitigates moderate colitis in mice.

Author

Laguna JG, Freitas ADS, Barroso FAL, De Jesus LCL, De Vasconcelos OAGG, Quaresma LS, Américo MF, Campos GM, Glória RA, Dutra JDCF, Da Silva TF, Vital KD, Fernandes SO, Souza RO, Martins FDS, Ferreira E, Santos TM, Birbrair A, De Oliveira MFA, Faria AMC, Carvalho RDO, Venanzi FM, Le Loir Y, Jan G, Guédon É, and Azevedo VAC

Abstract

Introduction and Objective: p62 is a human multifunctional adaptor protein involved in key cellular processes such as tissue homeostasis, inflammation, and cancer. It acts as a negative regulator of inflammasome complexes. It may thus be considered a good candidate for therapeutic use in inflammatory bowel diseases (IBD), such as colitis. Probiotics, including recombinant probiotic strains producing or delivering therapeutic biomolecules to the host mucosal surfaces, could help prevent and mitigate chronic intestinal inflammation. The objective of the present study was to combine the intrinsic immunomodulatory properties of the probiotic Lactococcus lactis NCDO2118 with its ability to deliver health-promoting molecules to enhance its protective and preventive effects in the context of ulcerative colitis (UC)., Material and Methods: This study was realized in vivo in which mice were supplemented with the recombinant strain. The intestinal barrier function was analyzed by monitoring permeability, secretory IgA total levels, mucin expression, and tight junction genes. Its integrity was evaluated by histological analyses. Regarding inflammation, colonic cytokine levels, myeloperoxidase (MPO), and expression of key genes were monitored. The intestinal microbiota composition was investigated using 16S rRNA Gene Sequencing., Results and Discussion: No protective effect of L. lactis NCDO2118 pExu: p62 was observed regarding mice clinical parameters compared to the L. lactis NCDO2118 pExu: empty . However, the recombinant strain, expressing p62, increased the goblet cell counts, upregulated Muc2 gene expression in the colon, and downregulated pro-inflammatory cytokines Tnf and Ifng when compared to L. lactis NCDO2118 pExu: empty and inflamed groups. This recombinant strain also decreased colonic MPO activity. No difference in the intestinal microbiota was observed between all treatments. Altogether, our results show that recombinant L. lactis NCDO2118 delivering p62 protein protected the intestinal mucosa and mitigated inflammatory damages caused by dextran sodium sulfate (DSS). We thus suggest that p62 may constitute part of a therapeutic approach targeting inflammation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Laguna, Freitas, Barroso, De Jesus, De Vasconcelos, Quaresma, Américo, Campos, Glória, Dutra, Da Silva, Vital, Fernandes, Souza, Martins, Ferreira, Santos, Birbrair, De Oliveira, Faria, Carvalho, Venanzi, Le Loir, Jan, Guédon and Azevedo.)

Published
2024
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