Search

Your search keyword '"Elisabeth Piccart"' showing total 2 results
Start Over Author "Elisabeth Piccart" Journal frontiers in molecular neuroscience
2 results on '"Elisabeth Piccart"'

1. Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons

Author

Svetlana M. Molchanova, Joris Comhair, Deniz Karadurmus, Elisabeth Piccart, Robert J. Harvey, Jean-Michel Rigo, Serge N. Schiffmann, Bert Brône, and David Gall

Subjects
dorsal striatum, medium spiny neurons, glycine receptors, tonic current, excitability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico–striato–thalamic loop, responsible for the initiation of voluntary movements and motor learning. GABAergic transmission exerts the main inhibitory control of MSNs. However, MSNs also express chloride-permeable glycine receptors (GlyRs) although their subunit composition and functional significance in the striatum is unknown. Here, we studied the function of GlyRs in MSNs of young adult mice. We show that MSNs express functional GlyRs, with α2 being the main agonist binding subunit. These receptors are extrasynaptic and depolarizing at resting state. The pharmacological inhibition of GlyRs, as well as inactivation of the GlyR α2 subunit gene hyperpolarize the membrane potential of MSNs and increase their action potential firing offset. Mice lacking GlyR α2 showed impaired motor memory consolidation without any changes in the initial motor performance. Taken together, these results demonstrate that tonically active GlyRs regulate the firing properties of MSNs and may thus affect the function of basal ganglia.

Published
2018
Full Text
View/download PDF

2. Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons

Author

Svetlana M. Molchanova, Joris Comhair, Deniz Karadurmus, Elisabeth Piccart, Robert J. Harvey, Jean-Michel Rigo, Serge N. Schiffmann, Bert Brône, and David Gall

Subjects
0301 basic medicine, Agonist, Glycine receptors, medicine.drug_class, medium spiny neurons, Striatum, Medium spiny neuron, tonic current, lcsh:RC321-571, Dorsal striatum, 03 medical and health sciences, Cellular and Molecular Neuroscience, Tonic current, 0302 clinical medicine, Basal ganglia, excitability, medicine, Receptor, dorsal striatum, Molecular Biology, Glycine receptor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Medium spiny neurons, Membrane potential, Excitability, Chemistry, glycine receptors, Biologie moléculaire, Depolarization, 3. Good health, 030104 developmental biology, Sciences cognitives, Neuroscience, 030217 neurology & neurosurgery
Abstract

Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico- striato-thalamic loop, responsible for the initiation of voluntary movements and motor learning. GABAergic transmission exerts the main inhibitory control of MSNs. However, MSNs also express chloride-permeable glycine receptors (GlyRs) although their subunit composition and functional significance in the striatum is unknown. Here, we studied the function of GlyRs in MSNs of young adult mice. We show that MSNs express functional GlyRs, with α2 being the main agonist binding subunit. These receptors are extrasynaptic and depolarizing at resting state. The pharmacological inhibition of GlyRs, as well as inactivation of the GlyR α2 subunit gene hyperpolarize the membrane potential of MSNs and increase their action potential firing offset. Mice lacking GlyR α2 showed impaired motor memory consolidation without any changes in the initial motor performance. Taken together, these results demonstrate that tonically active GlyRs regulate the firing properties of MSNs and may thus affect the function of basal ganglia., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results