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Your search keyword '"Brandt, Alexander"' showing total 11 results
Start Over Author "Brandt, Alexander" Journal frontiers in neurology
11 results on '"Brandt, Alexander"'

3. Altered Coupling of Psychological Relaxation and Regional Volume of Brain Reward Areas in Multiple Sclerosis

Author

Wakonig, Katharina, primary, Eitel, Fabian, additional, Ritter, Kerstin, additional, Hetzer, Stefan, additional, Schmitz-Hübsch, Tanja, additional, Bellmann-Strobl, Judith, additional, Haynes, John-Dylan, additional, Brandt, Alexander U., additional, Gold, Stefan M., additional, Paul, Friedemann, additional, and Weygandt, Martin, additional

Published
2020
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4. Differences in Advanced Magnetic Resonance Imaging in MOG-IgG and AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorders: A Comparative Study

Author

Schmidt, Felix A., primary, Chien, Claudia, additional, Kuchling, Joseph, additional, Bellmann-Strobl, Judith, additional, Ruprecht, Klemens, additional, Siebert, Nadja, additional, Asseyer, Susanna, additional, Jarius, Sven, additional, Brandt, Alexander U., additional, Scheel, Michael, additional, and Paul, Friedemann, additional

Published
2020
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7. Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS)

Author

Bäcker-Koduah, Priscilla, Bellmann-Strobl, Judith, Scheel, Michael, Wuerfel, Jens, Wernecke, Klaus-Dieter, Dörr, Jan, Brandt, Alexander Ulrich, and Paul, Friedemann

Subjects
Neurology, EDSS score, vitamin D deficiency, T2w lesion count, vitamin D, disease severity, Function and Dysfunction of the Nervous System, multiple sclerosis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research, EVIDIMS
Abstract

Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients. Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in Multiple Sclerosis (NCT01440062) baseline serum vitamin D levels were evaluated. Patients were dichotomized based on the definition of vitamin D deficiency which is reflected by a < 30 vs. ≥ 30 ng/ml level of 25-hydroxyvitamin D (25(OH)D). Possible associations between vitamin D deficiency and both clinical and MRI features of the disease were analyzed. Results: Median (25, 75% quartiles, Q) 25(OH)D level was 18 ng/ml (12, 24). Forty eight out of 53 (91%) patients had 25(OH)D levels < 30 ng/ml (p < 0.001). Patients with 25(OH)D ≥ 30 ng/ml had lower median (25, 75% Q) T2-weighted lesion counts [25 (24, 33)] compared to patients with 25(OH)D < 30 ng/ml [60 (36, 84), p = 0.03; adjusted for age, gender and disease duration: p < 0.001]. Expanded disability status scale (EDSS) score was negatively associated with serum 25(OH)D levels in a multiple linear regression, including age, sex, and disease duration (adjusted: p < 0.001). Interpretation: Most patients recruited in the EVIDIMS study were vitamin D deficient. Higher 25(OH)D levels were associated with reduced T2 weighted lesion count and lower EDSS scores.

Published
2019

8. MRI Markers and Functional Performance in Patients With CIS and MS: A Cross-Sectional Study

Author

Rasche, Ludwig, Scheel, Michael, Otte, Karen, Althoff, Patrik, Vuuren, Annemieke B. Van, Gieß, Rene M., Kuchling, Joseph, Bellmann-Strobl, Judith, Ruprecht, Klemens, Paul, Friedemann, Brandt, Alexander U., Schmitz-Hübsch, Tanja, and VU University medical center

Subjects
Neurology, atrophy, clinically isolated syndrome, thalamus, functional performance, Neurology (clinical), MSFC, Function and Dysfunction of the Nervous System, multiple sclerosis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, clinical outcomes, Original Research
Abstract

Introduction: Brain atrophy is a widely accepted marker of disease severity with association to clinical disability in multiple sclerosis (MS). It is unclear to which extent this association reflects common age effects on both atrophy and function. Objective: To explore how functional performance in gait, upper extremities and cognition is associated with brain atrophy in patients with Clinically Isolated Syndrome (CIS) and relapsing-remitting MS (RRMS), controlling for effects of age and sex. Methods: In 27 patients with CIS, 59 with RRMS (EDSS

Published
2018
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9. Normative Data and Minimally Detectable Change for Inner Retinal Layer Thicknesses Using a Semi-automated OCT Image Segmentation Pipeline

Author

Motamedi, Seyedamirhosein, primary, Gawlik, Kay, additional, Ayadi, Noah, additional, Zimmermann, Hanna G., additional, Asseyer, Susanna, additional, Bereuter, Charlotte, additional, Mikolajczak, Janine, additional, Paul, Friedemann, additional, Kadas, Ella Maria, additional, and Brandt, Alexander Ulrich, additional

Published
2019
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