1. TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome
- Author
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Natalie J Forde, Ahmad S Kanaan, Joanna Widomska, Shanmukha S Padmanabhuni, Ester Nespoli, John Alexander, Juan I Rodriguez Arranz, Siyan Fan, Rayan Houssari, Muhammad S Nawaz, Nuno R Zilhão, Luca Pagliaroli, Francesca Rizzo, Tamas Aranyi, Csaba Barta, Tobias M Boeckers, Dorret I Boomsma, Wim R Buisman, Jan K Buitelaar, Danielle Cath, Andrea Dietrich, Nicole Driessen, Petros Drineas, Michell Dunlap, Sarah Gerasch, Jeffrey C Glennon, Bastian Hengerer, Odile A van den Heuvel, Cathrine Jespersgaard, Harald E Möller, Kirsten R Müller-Vahl, Thaïra Openneer, Geert Poelmans, Petra J W Pouwels, Jeremiah M Scharf, Hreinn Stefansson, Zeynep Tümer, Dick Veltman, Ysbrand D van der Werf, Pieter J Hoekstra, Andrea Ludolph, Peristera Paschou, Netherlands Institute for Neuroscience (NIN), Experimental psychopathology, Leerstoel Hout, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Anatomy and neurosciences, Psychiatry, Physics and medical technology, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Biological Psychology, and EMGO+ - Mental Health
- Subjects
0301 basic medicine ,Netherlands Twin Register (NTR) ,tourette disorder ,BLOOD ,Tourette syndrome ,Etiology ,0302 clinical medicine ,genetics ,Aetiology ,GENE-EXPRESSION ,COPY NUMBER VARIANTS ,neuroimaging ,ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ,General Neuroscience ,TIC SEVERITY ,Clinical course ,ASSOCIATION ,animal models ,3. Good health ,Models, Animal ,Perspective ,Psychology ,DANISH CLINICAL COHORT ,medicine.medical_specialty ,Gilles de la Tourette Syndrome ,etiology ,lcsh:RC321-571 ,Marie curie ,Genetics ,03 medical and health sciences ,Animal model ,SDG 17 - Partnerships for the Goals ,Tourette-Syndrom ,Initial Training Network ,medicine ,Attention deficit hyperactivity disorder ,ddc:610 ,Genetik ,Psychiatry ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,35 YEAR PERSPECTIVE ,Tiermodell ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Network on ,TOURETTE-SYNDROME ,OBSESSIVE-COMPULSIVE DISORDER ,medicine.disease ,030104 developmental biology ,Endophenotype ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Contains fulltext : 168171.pdf (Publisher’s version ) (Open Access) Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.
- Published
- 2016