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Start Over Author "CARAI, ANDREA" Journal frontiers in oncology
16 results on '"CARAI, ANDREA"'

2. Case Report: Remarkable breakthrough: successful treatment of a rare intracranial mesenchymal, FET::CREB fusion-positive tumor treated with patient-tailored multimodal therapy

Author

D’Antonio, Federica, primary, Rossi, Sabrina, additional, Giovannoni, Isabella, additional, Alaggio, Rita, additional, Carai, Andrea, additional, Milano, Giuseppe M., additional, Cacchione, Antonella, additional, Cancellieri, Alessandra, additional, Gessi, Marco, additional, Antonelli, Manila, additional, Colafati, Giovanna S., additional, Megaro, Giacomina, additional, Vennarini, Sabina, additional, and Mastronuzzi, Angela, additional

Published
2023
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3. A systematic review of data sources for artificial intelligence applications in pediatric brain tumors in Europe: implications for bias and generalizability

Author

Tozzi, Alberto Eugenio, primary, Croci, Ileana, additional, Voicu, Paul, additional, Dotta, Francesco, additional, Colafati, Giovanna Stefania, additional, Carai, Andrea, additional, Fabozzi, Francesco, additional, Lacanna, Giuseppe, additional, Premuselli, Roberto, additional, and Mastronuzzi, Angela, additional

Published
2023
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4. Unraveling the impact of upfront chemotherapy and proton beam therapy on treatment outcome and follow-up in central nervous system germ cell tumors: a single center experience

Author

Del Baldo, Giada, primary, Vennarini, Sabina, additional, Toniutti, Maristella, additional, Abbas, Rachid, additional, Lorentini, Stefano, additional, Piccirilli, Eleonora, additional, Cacchione, Antonella, additional, Megaro, Giacomina, additional, Di Ruscio, Valentina, additional, De Ioris, Maria Antonietta, additional, De Salvo, Andrea, additional, Albino, Giulia, additional, Rossi, Sabrina, additional, Colafati, Giovanna Stefania, additional, Carai, Andrea, additional, and Mastronuzzi, Angela, additional

Published
2023
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6. Inter and intra-tumor heterogeneity of paediatric type diffuse high-grade gliomas revealed by single-cell mass cytometry

Author

Petrilli, Lucia Lisa, primary, Fuoco, Claudia, additional, Palma, Alessandro, additional, Pasquini, Luca, additional, Pericoli, Giulia, additional, Grabovska, Yura, additional, Mackay, Alan, additional, Rossi, Sabrina, additional, Carcaboso, Angel M., additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, Jones, Chris, additional, Cesareni, Gianni, additional, Locatelli, Franco, additional, and Vinci, Maria, additional

Published
2022
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7. Frequency and characterization of cognitive impairments in patients diagnosed with paediatric central nervous system tumours: a systematic review.

Author

Sciancalepore, Francesco, Fabozzi, Francesco, Albino, Giulia, Del Baldo, Giada, Di Ruscio, Valentina, Laus, Beatrice, Menegatti, Danilo, Premuselli, Roberto, Secco, Domitilla Elena, Tozzi, Alberto Eugenio, Lacorte, Eleonora, Vanacore, Nicola, Carai, Andrea, and Mastronuzzi, Angela

Subjects
CENTRAL nervous system tumors, CENTRAL nervous system, EXECUTIVE function, COGNITION disorders, COGNITION, TUMORS, PROSPECTIVE memory
Abstract

Background: This systematic review has been conducted with the aim of characterizing cognitive deficits and analyzing their frequency in survivors of paediatric Central Nervous System tumours. Materials and methods: All literature published up to January 2023 was retrieved searching the databases "PubMed", "Cochrane", "APA PsycInfo" and "CINAHL". The following set of pre-defined inclusion criteria were then individually applied to the selected articles in their full-text version: i) Retrospective/prospective longitudinal observational studies including only patients diagnosed with primary cerebral tumours at = 21 years (range 0-21); ii) Studies including patients evaluated for neuro-cognitive and neuro-psychological deficits from their diagnosis and/or from anti-tumoral therapies; iii) Studies reporting standardized tests evaluating patients' neuro-cognitive and neuro-psychological performances; iv) Patients with followups = 2 years from the end of their anti-tumoral therapies; v) Studies reporting frequencies of cognitive deficits. Results: 39 studies were included in the analysis. Of these, 35 assessed intellectual functioning, 30 examined memory domains, 24 assessed executive functions, 22 assessed attention, 16 examined visuo-spatial skills, and 15 explored language. A total of 34 studies assessed more than one cognitive function, only 5 studies limited their analysis on a single cognitive domain. Attention impairments were the most recurrent in this population, with a mean frequency of 52.3% after a median period post-treatment of 11.5 years. The other cognitive functions investigated in the studies showed a similar frequency of impairments, with executive functions, language, visuospatial skills and memory deficits occurring in about 40% of survivors after a similar post-treatment period. Longitudinal studies included in the systematic review showed a frequent decline over time of intellectual functioning. Conclusions: Survivors of paediatric Central Nervous System tumours experience cognitive sequelae characterized by significant impairments in the attention domain (52.3%), but also in the other cognitive functions. Future studies in this research field need to implement more cognitive interventions and effective, but less neurotoxic, tumour therapies to preserve or improve neurocognitive functioning and quality of life of this population. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era

Author

Carta, Roberto, primary, Del Baldo, Giada, additional, Miele, Evelina, additional, Po, Agnese, additional, Besharat, Zein Mersini, additional, Nazio, Francesca, additional, Colafati, Giovanna Stefania, additional, Piccirilli, Eleonora, additional, Agolini, Emanuele, additional, Rinelli, Martina, additional, Lodi, Mariachiara, additional, Cacchione, Antonella, additional, Carai, Andrea, additional, Boccuto, Luigi, additional, Ferretti, Elisabetta, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional

Published
2020
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13. Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome

Author

Petruzzellis, Giuseppe, primary, Valentini, Diletta, additional, del Bufalo, Francesca, additional, Ceglie, Giulia, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Agolini, Emanuele, additional, Diomedi-Camassei, Francesca, additional, Corsetti, Tiziana, additional, Alessi, Iside, additional, Mastronuzzi, Angela, additional, Locatelli, Franco, additional, and Cacchione, Antonella, additional

Published
2019
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14. Direct Involvement of Cranial Nerve V at Diagnosis in Patients With Diffuse Intrinsic Pontine Glioma: A Potential Magnetic Resonance Predictor of Short-Term Survival

Author

Colafati, Giovanna Stefania, primary, Voicu, Ioan Paul, additional, Carducci, Chiara, additional, Caulo, Massimo, additional, Vinci, Maria, additional, Diomedi-Camassei, Francesca, additional, Merli, Pietro, additional, Carai, Andrea, additional, Miele, Evelina, additional, Cacchione, Antonella, additional, Tomà, Paolo, additional, Locatelli, Franco, additional, and Mastronuzzi, Angela, additional

Published
2019
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15. BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas

Author

Del Bufalo, Francesca, primary, Ceglie, Giulia, additional, Cacchione, Antonella, additional, Alessi, Iside, additional, Colafati, Giovanna Stefania, additional, Carai, Andrea, additional, Diomedi-Camassei, Francesca, additional, De Billy, Emmanuel, additional, Agolini, Emanuele, additional, Mastronuzzi, Angela, additional, and Locatelli, Franco, additional

Published
2018
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16. Case Report: Remarkable breakthrough: successful treatment of a rare intracranial mesenchymal, FET::CREB fusion-positive tumor treated with patient-tailored multimodal therapy.

Author

D'Antonio F, Rossi S, Giovannoni I, Alaggio R, Carai A, Milano GM, Cacchione A, Cancellieri A, Gessi M, Antonelli M, Colafati GS, Megaro G, Vennarini S, and Mastronuzzi A

Abstract

Background: Intracranial mesenchymal tumors are a rare type of neoplasm (0.3% of all soft tissue tumors) characterized by a fusion of a FET family gene (usually EWSR1 , rarely FUS ) to CREB family genes ( CREB1, ATF1 , and CREM ) with a slow-growing and favorable prognosis. Mesenchymal tumors are most frequently localized in the subcutaneous tissue (typically in the limbs and hands) of young adults and have rarely been diagnosed in the central nervous system. Surgery is the gold standard treatment; adjuvant radiation therapy and chemotherapy with sarcoma-based regimens have been used in rare cases when complete surgical excision was not recommended. In terms of prognosis, these tumors show a tendency for local relapse. The longest patient outcomes reported in the literature are five years., Case Description: This case describes a 27-year-old woman with unconventional extracranial metastatic sites of myxoid intracranial mesenchymal tumor FET::CREB fusion-positive and high expression of PD-1 (40%) and PD-L1 (30%). Based on clinical, molecular, and histological characteristics, she underwent various local and systemic therapies, including surgery, proton beam therapy, the use of immune checkpoint inhibitors, and chemotherapy. These treatments led to a complete remission of the disease after eight years from tumor diagnosis., Conclusions: Our case sheds light on the importance of precision medicine and tailored therapy to explore new treatment opportunities for rare or unknown tumor entities., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 D’Antonio, Rossi, Giovannoni, Alaggio, Carai, Milano, Cacchione, Cancellieri, Gessi, Antonelli, Colafati, Megaro, Vennarini and Mastronuzzi.)

Published
2023
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