1. MSCs can be a double-edged sword in tumorigenesis
- Author
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Lu Zhang, Junyu Xiang, Fang Zhang, Limei Liu, and Chongling Hu
- Subjects
mesenchymal stem cells ,cancer immunotherapy ,extracellular vesicles ,innate immune cells ,adaptive immune cells ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer’s disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in cancer immunotherapy and their immunomodulatory mechanisms in cancers.
- Published
- 2022
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