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7 results on '"Petrillo Francesco"'

1. Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study

Author

Trotta, Maria Consiglia, primary, Gesualdo, Carlo, additional, Lepre, Caterina Claudia, additional, Russo, Marina, additional, Ferraraccio, Franca, additional, Panarese, Iacopo, additional, Marano, Ernesto, additional, Grieco, Paolo, additional, Petrillo, Francesco, additional, Hermenean, Anca, additional, Simonelli, Francesca, additional, D’Amico, Michele, additional, Bucolo, Claudio, additional, Lazzara, Francesca, additional, De Nigris, Filomena, additional, Rossi, Settimio, additional, and Platania, Chiara Bianca Maria, additional

Published
2024
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2. Editorial: Chronic Inflammation and Neurodegeneration in Retinal Disease

Author

Petrillo, Francesco, Gesualdo, Carlo, Platania, Chiara Bianca Maria, D’Amico, Michele, and Trotta, Maria Consiglia

Subjects
Pharmacology, chronic inflammation, diabetic retinopathy, Editorial, glaucoma, neurodegeneration, age-related macular degeneration, retinitis pigmenstosa
Published
2021

3. Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study

Author

Gesualdo, Carlo, primary, Balta, Cornel, additional, Platania, Chiara Bianca Maria, additional, Trotta, Maria Consiglia, additional, Herman, Hildegard, additional, Gharbia, Sami, additional, Rosu, Marcel, additional, Petrillo, Francesco, additional, Giunta, Salvatore, additional, Della Corte, Alberto, additional, Grieco, Paolo, additional, Bellavita, Rosa, additional, Simonelli, Francesca, additional, D’Amico, Michele, additional, Hermenean, Anca, additional, Rossi, Settimio, additional, and Bucolo, Claudio, additional

Published
2021
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4. Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

Author

Lazzara, Francesca, primary, Trotta, Maria Consiglia, additional, Platania, Chiara Bianca Maria, additional, D’Amico, Michele, additional, Petrillo, Francesco, additional, Galdiero, Marilena, additional, Gesualdo, Carlo, additional, Rossi, Settimio, additional, Drago, Filippo, additional, and Bucolo, Claudio, additional

Published
2020
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5. Corrigendum: Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose

Author

Maisto, Rosa, primary, Trotta, Maria Consiglia, additional, Petrillo, Francesco, additional, Izzo, Sara, additional, Cuomo, Giovanna, additional, Alfano, Roberto, additional, Hermenean, Anca, additional, Barcia, Jorge Miquel, additional, Galdiero, Marilena, additional, Platania, Chiara Bianca Maria, additional, Bucolo, Claudio, additional, and D’Amico, Michele, additional

Published
2020
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6. Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose

Author

Maisto, Rosa, primary, Trotta, Maria Consiglia, additional, Petrillo, Francesco, additional, Izzo, Sara, additional, Cuomo, Giovanna, additional, Alfano, Roberto, additional, Hermenean, Anca, additional, Barcia, Jorge Miquel, additional, Galdiero, Marilena, additional, Platania, Chiara Bianca Maria, additional, Bucolo, Claudio, additional, and D’Amico, Michele, additional

Published
2020
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7. Corrigendum: Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose

Author

Marilena Galdiero, Rosa Maisto, Maria Consiglia Trotta, Chiara Bianca Maria Platania, Michele D'Amico, Claudio Bucolo, Roberto Alfano, Jorge Miquel Barcia, Giovanna Cuomo, Anca Hermenean, Francesco Petrillo, Sara Izzo, Maisto, Rosa, Trotta, Maria Consiglia, Petrillo, Francesco, Izzo, Sara, Cuomo, Giovanna, Alfano, Roberto, Hermenean, Anca, Miquel Barcia, Jorge, Galdiero, Marilena, Bianca Maria Platania, Chiara, Bucolo, Claudio, and D'Amico, Michele

Subjects
0301 basic medicine, Angiogenesis, Stimulation, exosomes, retinal photoreceptors, exosomes, miRNAs, resolvin D1, VEGF, Neovascularization, 03 medical and health sciences, chemistry.chemical_compound, retinal photoreceptors, 0302 clinical medicine, medicine, Pharmacology (medical), Receptor, Original Research, Pharmacology, Chemistry, lcsh:RM1-950, Correction, Retinal, Transfection, VEGF, Microvesicles, Cell biology, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, miRNAs, resolvin D1, medicine.symptom, Intracellular
Abstract

Stimulation of retinal photoreceptors with elevated glucose concentration (30 mM) for 96 hours, served as diabetic retinopathy in-vitro model to study Resolvin D1 (50 nM) effects on neovascularization. VEGF and anti-angiogenic miR-20a-3p, miR-20a-5p, miR-106a-5p and miR-20b expression was assessed either in photoreceptors exposed to HG or in exosomes released by those cells. High glucose increased VEGF levels and concurrently decreased anti-angiogenic miRNAs content in photoreceptors and exosomes. RvD1 reverted the effects of glucose damage in photoreceptors and exosomal pro-angiogenic potential, tested with the HUVEC angiogenesis assay. By activating FPR2 receptor, RvD1 modulated both the expression of anti-angiogenic miRNA, which decrease VEGF, and the pro-angiogenic potential of exosomes released by primary retinal cells. HUVEC transfection with miR-20a-3p, miR-20a-5p, miR-106a-5p and miR-20b antagomirs, followed by exposure to exosomes from photoreceptors, confirmed the VEGF-related miRNAs mechanism and the anti-angiogenic effects of RvD1.

Published
2020

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