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The characterization of breathing dynamics provides researchers and clinicians the ability to differentiate respiratory compensation, impairment, disease progression, ventilator assistance, and the onset of respiratory failure. However, within many sub-fields of respiratory physiology, we still have challenges identifying changes within the breathing dynamics and critical respiratory states. We discuss one fundamental modeling of breathing and how modeling imprecise assumptions decades ago regarding breathing are still propagating into our quantitative analysis today, limiting our characterization and modeling of breathing. The assumption that breathing is a continuous sinusoidal wave that can consist of a single frequency which is composed of a stationary time-invariant process has limited our expanded discussion of breathing dynamics, modeling, functional testings, and metrics. Therefore, we address major misnomers regarding breathing dynamics, specifically rate, rhythm, frequency, and period. We demonstrate how these misnomers impact the characterization and modeling through the force equations that are linked to the Work of Breathing (WoB) and our interpretation of breathing dynamics through the fundamental models and create possible erroneous evaluations of work of breathing. This discussion and simplified non-periodic WoB models ultimately sets the foundation for improved quantitative approaches needed to further our understanding of breathing dynamics, compensation, and adaptation. [ABSTRACT FROM AUTHOR]

The characterization of breathing dynamics provides researchers and clinicians the ability to differentiate respiratory compensation, impairment, disease progression, ventilator assistance, and the onset of respiratory failure. However, within many sub-fields of respiratory physiology, we still have challenges identifying changes within the breathing dynamics and critical respiratory states. We discuss one fundamental modeling of breathing and how modeling imprecise assumptions decades ago regarding breathing are still propagating into our quantitative analysis today, limiting our characterization and modeling of breathing. The assumption that breathing is a continuous sinusoidal wave that can consist of a single frequency which is composed of a stationary time-invariant process has limited our expanded discussion of breathing dynamics, modeling, functional testings, and metrics. Therefore, we address major misnomers regarding breathing dynamics, specifically rate, rhythm, frequency, and period. We demonstrate how these misnomers impact the characterization and modeling through the force equations that are linked to the Work of Breathing (WoB) and our interpretation of breathing dynamics through the fundamental models and create possible erroneous evaluations of work of breathing. This discussion and simplified non-periodic WoB models ultimately sets the foundation for improved quantitative approaches needed to further our understanding of breathing dynamics, compensation, and adaptation.

Assessments of respiratory response and animal activity are useful endpoints in drug pharmacology and safety research. We investigated whether continuous, direct monitoring of breathing rate and body motion in animals in the home cage using the Vum Digital Smart House can complement standard measurements in enabling more granular detection of the onset and severity of physiologic events related to lung injury in a well-established rodent model of paraquat (PQ) toxicity. In rats administered PQ, breathing rate was significantly elevated while body motion was significantly reduced following dosing and extending throughout the 14-day study duration for breathing rate and at least 5 days for both nighttime and daytime body motion. Time course differences in these endpoints in response to the potential ameliorative test article bardoxolone were also readily detected. More complete than standard in-life measurements, breathing rate and body motion tracked injury progression continuously over the full study time period and aligned with, and informed on interval changes in clinical pathology. In addition, breathing rates correlated with terminal pathology measurements, such as normalized lung weights and histologic alveolar damage and edema. This study is a preliminary evaluation of the technology; our results demonstrate that continuously measured breathing rate and body motion served as physiologically relevant readouts to assess lung injury progression and drug response in a respiratory injury animal model.

Assessments of respiratory response and animal activity are useful endpoints in drug pharmacology and safety research. We investigated whether continuous, direct monitoring of breathing rate and body motion in animals in the home cage using the Vum Digital Smart House can complement standard measurements in enabling more granular detection of the onset and severity of physiologic events related to lung injury in a well-established rodent model of paraquat (PQ) toxicity. In rats administered PQ, breathing rate was significantly elevated while body motion was significantly reduced following dosing and extending throughout the 14-day study duration for breathing rate and at least 5 days for both nighttime and daytime body motion. Time course differences in these endpoints in response to the potential ameliorative test article bardoxolone were also readily detected. More complete than standard in-life measurements, breathing rate and body motion tracked injury progression continuously over the full study time period and aligned with, and informed on interval changes in clinical pathology. In addition, breathing rates correlated with terminal pathology measurements, such as normalized lung weights and histologic alveolar damage and edema. This study is a preliminary evaluation of the technology; our results demonstrate that continuously measured breathing rate and body motion served as physiologically relevant readouts to assess lung injury progression and drug response in a respiratory injury animal model. [ABSTRACT FROM AUTHOR]