1. Longitudinal progression of choroid plexus enlargement is associated with female sex, cognitive decline and ApoE E4 homozygote status
- Author
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Julie Novakova Martinkova, Maria Teresa Ferretti, Alberto Ferrari, Ondrej Lerch, Veronika Matuskova, Juraj Secnik, Jakub Hort, and for the Alzheimer’s Disease Neuroimaging Initiative
- Subjects
choroid plexus ,longitudinal analysis ,sex differences ,Alzheimer’s disease ,cognitive impairment ,Psychiatry ,RC435-571 - Abstract
IntroductionChoroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. In this pilot study, we aimed to elucidate the association between longitudinal changes in CP volume, sex and cognitive impairment.MethodsWe assessed longitudinal changes in CP volume in a cohort of n = 613 subjects across n = 2,334 datapoints from ADNI 2 and ADNI-GO, belonging to cognitively unimpaired (CN), stable mild cognitive impairment (MCI), clinically diagnosed Alzheimer’s disease dementia (AD) or convertor (to either AD or MCI) subgroups. CP volume was automatically segmented and used as a response variable in linear mixed effect models with random intercept clustered by patient identity. Temporal effects of select variables were assessed by interactions and subgroup analyses.ResultsWe found an overall significant increase of CP volume in time (14.92 mm3 per year, 95% confidence interval, CI (11.05, 18.77), p
- Published
- 2023
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