1. β-Cyclodextrin promoted oxidation of primary amines to nitriles in water
- Author
-
Zhong Li, Dong-Po Shi, and Hongbing Ji
- Subjects
carbohydrates (lipids) ,chemistry.chemical_classification ,Primary (chemistry) ,Cyclodextrin ,Chemistry ,General Chemical Engineering ,technology, industry, and agriculture ,polycyclic compounds ,Organic chemistry ,lipids (amino acids, peptides, and proteins) ,Catalysis - Abstract
A facile, efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by β-cyclodextrin (β-CD) has been developed in water for the first time, and the behavior of β-cyclodextrin that catalyzed the primary amines to nitriles in water was investigated. It was found that the primary amines which could form host-guest complexes with β-cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature. The results show that β-cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.
- Published
- 2009
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