1. In vitro, ex vivo and in vivo models: A comparative analysis of Paracoccidioides spp. proteomic studies.
- Author
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Parente-Rocha JA, Tomazett MV, Pigosso LL, Bailão AM, Ferreira de Souza A, Paccez JD, Baeza LC, Pereira M, Silva Bailão MG, Borges CL, and Maria de Almeida Soares C
- Subjects
- Animals, Humans, Mice, Nitrosative Stress, Oxidative Stress, Proteomics methods, Spores, Fungal metabolism, Fungal Proteins metabolism, Host-Pathogen Interactions, Paracoccidioides metabolism, Paracoccidioides pathogenicity, Paracoccidioidomycosis microbiology, Virulence Factors metabolism
- Abstract
Members of the Paracoccidioides complex are human pathogens that infect different anatomic sites in the host. The ability of Paracoccidioides spp. to infect host niches is putatively supported by a wide range of virulence factors, as well as fitness attributes that may comprise the transition from mycelia/conidia to yeast cells, response to deprivation of micronutrients in the host, expression of adhesins on the cell surface, response to oxidative and nitrosative stresses, as well as the secretion of hydrolytic enzymes in the host tissue. Our understanding of how those molecules can contribute to the infection establishment has been increasing significantly, through the utilization of several models, including in vitro, ex vivo and in vivo infection in animal models. In this review we present an update of our understanding on the strategies used by the pathogen to establish infection. Our results were obtained through a comparative proteomic analysis of Paracoccidioides spp. in models of infection., (Copyright © 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2018
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