1. Mysterious path ofBorrelia spielmanii: spreading without morphological alteration of collagen type I and IV
- Author
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Dusan Lalosevic, Dejan Ogorelica, Verica Simin, Nenad Vranješ, Ivan Čapo, and Pavle Banović
- Subjects
Microbiology (medical) ,Pathology ,medicine.medical_specialty ,biology ,medicine.diagnostic_test ,MMP9 ,biology.organism_classification ,Microbiology ,Serology ,Extracellular matrix ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Borrelia ,Skin biopsy ,medicine ,Erythema migrans ,030211 gastroenterology & hepatology ,CD8 ,Borrelia spielmanii - Abstract
The majority of suggested mechanisms of Borrelia spreading inside erythema migrans (EM) are developed from in vitro studies and animal models. This report is the first to describe pathomorphological substrate of EM caused by Borrelia spielmanii in humans, addressing the hypothesis of enhanced Borrelia penetration through extracellular matrix. In the process of ruling out of atypical Masters’ disease, we conducted a punch biopsy of suspected EM and a two-tier serology testing for Lyme borreliosis, where we registered antibodies against B. spielmanii. Skin biopsy showed CD4+and CD8+lymphocyte involvement and high activity of matrix metalloproteinase 9. No alterations were detected in distribution and morphology of collagen type I and IV. Therefore, it is suggested that other mechanisms should be considered as major contributing factors to local spreading of B. spielmanii.
- Published
- 2019
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