1. Expression of Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16 in cervical dysplasia.
- Author
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Kolben TM, Kraft F, Kolben T, Goess C, Semmlinger A, Dannecker C, Schmoeckel E, Mayr D, Sommer NN, Mahner S, and Jeschke U
- Subjects
- CA-19-9 Antigen, Case-Control Studies, Cyclin-Dependent Kinase Inhibitor p16 genetics, Disease Progression, Female, Gene Expression, Humans, Immunohistochemistry, Neoplasm Grading, Sialyl Lewis X Antigen, Stathmin genetics, Uterine Cervical Dysplasia genetics, Biomarkers, Tumor, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Oligosaccharides metabolism, Stathmin metabolism, Uterine Cervical Dysplasia metabolism, Uterine Cervical Dysplasia pathology
- Abstract
Aim: Cervical intraepithelial neoplasia (CIN) is commonly divided into three grades. Guidelines increasingly recommend surgery only in CIN 3 lesions. We investigated markers to evaluate differences in CIN 2 and 3 lesions as well as possible predictors for regression/progression in CIN 2 lesions., Materials & Methods: Biopsies (n = 128) of healthy cervical tissue and CIN 1-3 were stained for Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16., Results: We observed significant differences between CIN 2 and 3 lesions for Sialyl Lewis a, Sialyl Lewis x, Gal-3, Gal-7, STMN1 and p16. Expression of Sialyl Lewis a was significantly higher in CIN 2 patients who progressed during follow-up., Conclusion: Significant differences in marker expression support the differentiation of CIN 2 and 3. Lewis a may help to predict progression/regression in CIN 2 patients.
- Published
- 2017
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