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Start Over Author "Morgagni, P" Journal gastric cancer
18 results on '"Morgagni, P"'

1. Genomic events stratifying prognosis of early gastric cancer

Author

Molinari, Chiara, Solaini, Leonardo, Rebuzzi, Francesca, Tedaldi, Gianluca, Angeli, Davide, Petracci, Elisabetta, Prascevic, Dusan, Ewald, Jan, Rahm, Erhard, Canale, Matteo, Giovanni, Martinelli, Tomezzoli, Anna, Bencivenga, Maria, Ambrosio, Maria Raffaella, Marrelli, Daniele, Morgagni, Paolo, Ercolani, Giorgio, Ulivi, Paola, and Saragoni, Luca

Published
2024
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2. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape: Bertinoro Workshop, November 2022

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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3. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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4. Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis

Author

Molinari, Chiara, Tedaldi, Gianluca, Rebuzzi, Francesca, Morgagni, Paolo, Capelli, Laura, Ravaioli, Sara, Tumedei, Maria Maddalena, Scarpi, Emanuela, Tomezzoli, Anna, Bernasconi, Riccardo, Ambrosio, Maria Raffaella, D’Ignazio, Alessia, Solaini, Leonardo, Limarzi, Francesco, Ercolani, Giorgio, Martinelli, Giovanni, Ulivi, Paola, and Saragoni, Luca

Published
2021
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6. International consensus on a complications list after gastrectomy for cancer

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Marrelli, Daniele, Reim, Daniel, Piessen, Guillaume, Matos da Costa, Paulo, Reynolds, John V., Meyer, Hans-Joachim, Morgagni, Paolo, Gockel, Ines, Lara Santos, Lucio, Jensen, Lone Susanne, Murphy, Thomas, Preston, Shaun R., Ter-Ovanesov, Mikhail, Fumagalli Romario, Uberto, Degiuli, Maurizio, Kielan, Wojciech, Mönig, Stefan, Kołodziejczyk, Piotr, Polkowski, Wojciech, Hardwick, Richard, Pera, Manuel, Johansson, Jan, Schneider, Paul M., de Steur, Wobbe O., Gisbertz, Suzanne S., Hartgrink, Henk, van Sandick, Joanna W., Portolani, Nazario, Hölscher, Arnulf H., Botticini, Maristella, Roviello, Franco, Mariette, Christophe, Allum, William, and De Manzoni, Giovanni

Published
2019
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7. The Italian Research Group for Gastric Cancer (GIRCG) guidelines for gastric cancer staging and treatment: 2015

Author

De Manzoni, Giovanni, Marrelli, Daniele, Baiocchi, Gian Luca, Morgagni, Paolo, Saragoni, Luca, Degiuli, Maurizio, Donini, Annibale, Fumagalli, Uberto, Mazzei, Maria Antonietta, Pacelli, Fabio, Tomezzoli, Anna, Berselli, Mattia, Catalano, Filippo, Di Leo, Alberto, Framarini, Massimo, Giacopuzzi, Simone, Graziosi, Luigina, Marchet, Alberto, Marini, Mario, Milandri, Carlo, Mura, Gianni, Orsenigo, Elena, Quagliuolo, Vittorio, Rausei, Stefano, Ricci, Riccardo, Rosa, Fausto, Roviello, Giandomenico, Sansonetti, Andrea, Sgroi, Giovanni, Tiberio, Guido Alberto Massimo, Verlato, Giuseppe, Vindigni, Carla, Rosati, Riccardo, and Roviello, Franco

Published
2017
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8. Follow-up after gastrectomy for cancer: the Charter Scaligero Consensus Conference

Author

Baiocchi, Gian Luca, D’Ugo, Domenico, Coit, Daniel, Hardwick, Richard, Kassab, Paulo, Nashimoto, Atsushi, Marrelli, Daniele, Allum, William, Berruti, Alfredo, Chandramohan, Servarayan Murugesan, Coburn, Natalie, Gonzàlez-Moreno, Santiago, Hoelscher, Arnulf, Jansen, Edwin, Leja, Marcis, Mariette, Christophe, Meyer, Hans-Joachim, Mönig, Stefan, Morgagni, Paolo, Ott, Katia, Preston, Shaun, Rha, Sun Young, Roviello, Franco, Sano, Takeshi, Sasako, Mitsuru, Shimada, Hideaki, Schuhmacher, Cristoph, So Bok-yan, Jimmy, Strong, Vivian, Yoshikawa, Takaki, Terashima, Masanori, Ter-Ovanesov, Michail, Van der Velde, Cornelis, Memo, Maurizio, Castelli, Francesco, Pecorelli, Sergio, Detogni, Claudio, Kodera, Yasuhiro, and de Manzoni, Giovanni

Published
2016
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9. Surgical management of duodenal stump fistula after elective gastrectomy for malignancy: an Italian retrospective multicenter study

Author

Cozzaglio, Luca, Giovenzana, Marco, Biffi, Roberto, Cobianchi, Lorenzo, Coniglio, Arianna, Framarini, Massimo, Gerard, Leonardo, Gianotti, Luca, Marchet, Alberto, Mazzaferro, Vincenzo, Morgagni, Paolo, Orsenigo, Elena, Rausei, Stefano, Romano, Fabrizio, Rosa, Fausto, Rosati, Riccardo, Roviello, Francesco, Sacchi, Matteo, Morenghi, Emanuela, and Quagliuolo, Vittorio

Published
2016
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16. Nodal abdominal spread in adenocarcinoma of the cardia. Results of a multicenter prospective study

Author

de Manzoni, Giovanni, Morgagni, Paolo, Roviello, Franco, Di Leo, Alberto, Saragoni, Luca, Marrelli, Daniele, Guglielmi, Alfredo, Carli, Alfonso, Folli, Secondo, and Cordiano, Claudio

Abstract

Precise knowledge of the abdominal nodal spread of cardia adenocarcinoma in relation to the depth of invasion of the tumor and its longitudinal extension may be very important for the surgeon as a guide in choosing the type of resection and lymphadenectomy.Precise knowledge of the abdominal nodal spread of cardia adenocarcinoma in relation to the depth of invasion of the tumor and its longitudinal extension may be very important for the surgeon as a guide in choosing the type of resection and lymphadenectomy.

Published
1998
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17. Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis

Author

Riccardo Bernasconi, Giorgio Ercolani, Laura Capelli, Paola Ulivi, Chiara Molinari, Maria Raffaella Ambrosio, Giovanni Martinelli, Alessia D'Ignazio, Luca Saragoni, Paolo Morgagni, Leonardo Solaini, Anna Tomezzoli, Gianluca Tedaldi, Emanuela Scarpi, Sara Ravaioli, Francesca Rebuzzi, Maria Maddalena Tumedei, Francesco Limarzi, Molinari C., Tedaldi G., Rebuzzi F., Morgagni P., Capelli L., Ravaioli S., Tumedei M.M., Scarpi E., Tomezzoli A., Bernasconi R., Ambrosio M.R., D'Ignazio A., Solaini L., Limarzi F., Ercolani G., Martinelli G., Ulivi P., and Saragoni L.

Subjects
Male, Cancer Research, genetic structures, Loss of Heterozygosity, Gastroenterology, Loss of heterozygosity, 0302 clinical medicine, Surgical oncology, Submucosa, TP53, Lymph node, Early Detection of Cancer, Aged, 80 and over, General Medicine, Middle Aged, Prognosis, Immunohistochemistry, medicine.anatomical_structure, Italy, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Submucosa-penetrating tumor, Female, Microsatellite Instability, 030211 gastroenterology & hepatology, Adult, medicine.medical_specialty, DNA Copy Number Variations, 03 medical and health sciences, GATA6, Stomach Neoplasms, Internal medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm Invasiveness, Aged, Retrospective Studies, business.industry, Gastric Mucins, Microsatellite instability, Cancer, medicine.disease, Early Gastric Cancer, MUC6, Gastric Mucosa, Mutation, Tumor Suppressor Protein p53, business, Microsatellite Repeats
Abstract

Background: Early Gastric Cancer (EGC) reaches 25% of the gastric cancers surgically treated in some areas of Northeastern Italy and is usually characterized by a good prognosis. However, among EGCs classified according to Kodama’s criteria, Pen A subgroup is characterized by extensive submucosal invasion, lymph node metastases and worse prognosis, whereas Pen B subgroup by better prognosis. The aim of the study was to characterize the differences between Pen A, Pen B and locally advanced gastric cancer (T3N0) in order to identify biomarkers involved in aggressiveness and clinical outcome. Methods: We selected 33 Pen A, 34 Pen B and 20 T3N0 tumors and performed immunohistochemistry of mucins, copy number variation analysis of a gene panel, microsatellite instability (MSI), TP53 mutation and loss of heterozygosity (LOH) analyses. Results: Pen A subgroup was characterized by MUC6 overexpression (p = 0.021). Otherwise, the Pen B subgroup was significantly associated with the amplification of GATA6 gene (p = 0.002). The higher percentage of MSI tumors was observed in T3N0 group (p = 0.002), but no significant differences between EGC types were found. Finally, TP53 gene analysis showed that 32.8% of Pen tumors have a mutation in exons 5–8 and 50.0% presented LOH. Co-occurrence of TP53 mutation and LOH mainly characterized Pen A tumors (p = 0.022). Conclusions: Our analyses revealed that clinico-pathological parameters, microsatellite status and frequency of TP53 mutations do not seem to distinguish Pen subgroups. Conversely, the amplification of GATA6 was associated with Pen B, as well as the overexpression of MUC6 and the TP53mut/LOH significantly characterized Pen A.

Published
2020
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18. Naso-gastric or naso-jejunal decompression after partial distal gastrectomy for gastric cancer. Final results of a multicenter prospective randomized trial

Author

Franco Roviello, Massimo Framarini, Paolo Morgagni, Giovanni Battista Doglietto, Fabio Pacelli, Marcello Covino, Riccardo Casadei, Fausto Rosa, Giovanni de Manzoni, Luigi Cristadoro, Corrado Pedrazzani, Annibale Donini, Daniele Marrelli, Luca Cozzaglio, Pacelli F, Rosa F, Marrelli D, Morgagni P, Framarini M, Cristadoro L, Pedrazzani C, Casadei R, Cozzaglio L, Covino M, Donini A, Roviello F, de Manzoni G, and Doglietto GB.

Subjects
Decompression, Male, Cancer Research, medicine.medical_specialty, Anastomosis, Settore MED/18 - CHIRURGIA GENERALE, medicine.medical_treatment, Gastroenterology, Roux-en-Y, Postoperative Complications, Stomach Neoplasms, Surgical, Internal medicine, naso-jejunal, medicine, Humans, Prospective Studies, Elective surgery, Prospective cohort study, Aged, Billroth II, business.industry, Medicine (all), Anastomosis, Roux-en-Y, General Medicine, Middle Aged, Decompression, Surgical, Gastroenterostomy, gastrectomy, Surgery, Treatment Outcome, Oncology, Partial distal gastrectomy, Female, Gastrectomy, Gastric cancer, Gastric decompression, business, naso-gastric, Gastric cancer, Partial distal gastrectomy, Gastric decompression, Abdominal surgery
Abstract

BACKGROUND: Only a few, small, monocentric randomized controlled trials (RCTs) have compared routine vs. no placement of a nasogastric or nasojejunal tube decompression (NG/NJT) in patients undergoing partial distal gastrectomy (PDG) for gastric cancer. However, to our knowledge, no multicenter prospective RCT has analyzed the role of decompression after both the Billroth II (BII) procedure and Roux-en-Y (RY) gastrojejunostomy. The aim of this study was to determine whether NG/NJT prevents the consequences of postoperative ileus after PDG for gastric cancer after both BII reconstruction and RY. METHODS: Two hundred seventy patients undergoing PDG for gastric cancer were randomly assigned NG/NJT placement (NG/NJT group) or not (no-NG/NJT group) with either Billroth II gastrojejunostomy or Roux-en-Y gastrojejunostomy. The patients were monitored for postoperative complications, mortality, and postoperative course. RESULTS: By January 2010 to June 2012, among 270 patients undergoing PDG for gastric cancer, 134 were randomly assigned to NG/NJT placement (NG/NJT group) and 136 to no decompression (no-NG/NJT group). Time to passage of flatus was significantly shorter in the NG/NJT group than in the no-NG/NJT group, but only after RY reconstruction (3.3 ± 1.5 vs. 4.3 ± 1.6 days, P < 0.001, respectively). Postoperative abdominal distention was significantly lower in the NG/NJT group than in the no-NG/NJT group after both BII and the RY procedure (P < 0.001). No significant differences in postoperative mortality or morbidity, especially anastomotic leakage or intra-abdominal sepsis, were observed between the groups. CONCLUSION: Routine placement of an NG/NJT after BII and RY PDG is not necessary in elective surgery for gastric cancer.

Published
2013
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