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Your search keyword '"LOUVEL, D."' showing total 3 results
Start Over Author "LOUVEL, D." Journal gastroenterologie clinique et biologique
3 results on '"LOUVEL, D."'

1. [Acute pancreatitis induced by valproic acid].

Author

Croizet O, Louvel D, Teulière JP, Buscail L, Escourrou J, and Frexinos J

Subjects
Acute Disease, Adult, Epilepsy, Absence drug therapy, Humans, Male, Valproic Acid therapeutic use, Pancreatitis chemically induced, Valproic Acid adverse effects
Published
1994

2. [Digestive symptoms in the course of benzodiazepine withdrawal syndrome].

Author

Louvel D, Delvaux M, Larrue V, Moreau J, Bonnafous C, Bueno L, and Frexinos J

Subjects
Anxiety Disorders drug therapy, Bromazepam therapeutic use, Drug Therapy, Combination, Female, Gastrointestinal Motility drug effects, Humans, Lorazepam therapeutic use, Middle Aged, Bromazepam adverse effects, Diarrhea chemically induced, Lorazepam adverse effects, Substance Withdrawal Syndrome
Published
1994

3. [Transfection of pancreatic acinar cells (AR4-2J) by bFGF modifies cell morphology and biosynthesis of pancreatic secretory enzymes].

Author

Louvel D, Estival A, Couderc B, Prats H, Hollande E, Vaysse N, and Clemente F

Subjects
Amylases analysis, Amylases genetics, Animals, Cells, Cultured, Fibroblast Growth Factor 2 analysis, In Vitro Techniques, Islets of Langerhans enzymology, Islets of Langerhans ultrastructure, Lipase analysis, Lipase genetics, RNA, Messenger analysis, Rats, Transfection, Fibroblast Growth Factor 2 genetics, Islets of Langerhans physiology, Pancreatic Neoplasms genetics
Abstract

Basic fibroblast growth factor (bFGF or FGF-2) is present in the basal membrane of pancreatic cells during the pancreatic embryonic development. The expression of bFGF receptors has been described in normal pancreatic cells. By contrast, pancreatic cancer cells express not only the bFGF receptors but also the bFGF itself. With the aim of understanding the effects induced by the production of bFGF by pancreatic cancer cells, the pancreatic acinar cell line (AR4-2J) was used. AR4-2J cells do not produce bFGF but express bFGF receptors. These cells were transfected with a vector containing the bFGF cDNA encoding the three different forms of bFGF characterized in tumor cells. Results showed that the bFGF expression induced important phenotypic and enzymatic modifications. The transfected cells lost some morphological features of the acinar cells and expressed amylase and lipase at low levels (a 90% decrease for amylase activity, whereas lipase activity was barely detectable). These results suggest that bFGF could be involved in maintaining pancreatic cells in a slightly differentiated state.

Published
1992

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