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19 results on '"Accarie A"'

2. Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia

Author

Wauters, Lucas, primary, Ceulemans, Matthias, additional, Frings, Dennis, additional, Lambaerts, Maarten, additional, Accarie, Alison, additional, Toth, Joran, additional, Mols, Raf, additional, Augustijns, Patrick, additional, De Hertogh, Gert, additional, Van Oudenhove, Lukas, additional, Tack, Jan, additional, and Vanuytsel, Tim, additional

Published
2021
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8. Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia

Author

Maarten Lambaerts, Gert De Hertogh, Lucas Wauters, Lukas Van Oudenhove, Tim Vanuytsel, Matthias Ceulemans, Jan Tack, Alison Accarie, Raf Mols, Patrick Augustijns, Joran Toth, and Dennis Frings

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Duodenum, proton pump inhibitor, medicine.drug_class, Proton-pump inhibitor, Inflammation, Gastroenterology, Permeability, Bile Acids and Salts, Pantoprazole 40 MG, Belgium, Internal medicine, Eosinophilia, Healthy volunteers, Humans, Medicine, In patient, Mast Cells, Prospective Studies, Duodenal Diseases, Dyspepsia, Intestinal Mucosa, Pantoprazole, Hepatology, business.industry, Proton Pump Inhibitors, Inflammatory Bowel Diseases, functional dyspepsia, Pathophysiology, Treatment Outcome, inflammation, Permeability (electromagnetism), Case-Control Studies, Female, Inflammation Mediators, permeability, medicine.symptom, business
Abstract

BACKGROUND & AIMS: Despite the growing recognition of duodenal alterations in the pathophysiology of functional dyspepsia (FD), the effect and mechanism of proton pump inhibitors (PPIs) or first-line therapy remain unclear. We studied duodenal and systemic alterations in relation to PPI therapy in patients with FD and healthy volunteers (HVs). METHODS: We performed a prospective interventional study assessing symptoms (Patient Assessment of Gastrointestinal Symptom Severity Index), duodenal alterations, and systemic factors in patients with FD ("FD-starters") and HVs before and after PPI therapy (pantoprazole 40 mg once daily for 4 weeks). Duodenal mucosal eosinophils, mast cells and permeability were quantified. Luminal pH and bile salts were determined in duodenal aspirates. Procedures were also performed in PPI-refractory patients with FD ("FD-stoppers") before and 8 weeks after PPI withdrawal. Between- and within-group changes from baseline and associations with duodenal or systemic factors were analyzed using linear mixed models. RESULTS: The study was completed by 30 HV, 27 FD-starters, and 18 FD-stoppers. Symptoms and duodenal eosinophils, mast cells (all, P < .0001), and paracellular passage (P = .02) were significantly higher in FD-starters vs HVs and reduced with PPI therapy. Symptoms and duodenal immune cells also decreased in FD-stoppers off PPIs. In contrast, immune cells and permeability increased in HVs on PPIs. Dyspeptic symptoms correlated with eosinophils before and during PPI therapy, and increased eosinophils and permeability in HVs on PPIs were associated with changes in bile salts. CONCLUSIONS: We provide the first prospective evidence for eosinophil-reducing effects as a therapeutic mechanism of PPIs in FD, with differential effects in HVs pointing to a role of luminal changes. ClinicalTrials.gov, Number: NCT03545243. ispartof: GASTROENTEROLOGY vol:160 issue:5 pages:1521-+ ispartof: location:United States status: published

Published
2021

17. Tu1253 - Sex Difference in the Colonic Features in Response to a Combinaison of Stress in the Biobbreeding Rat Model

Author

Ricard Farré Marti, Joran Toth, Jan Tack, Alison Accarie, and Tim Vanuytsel

Subjects
0301 basic medicine, medicine.medical_specialty, Hepatology, business.industry, Rat model, Gastroenterology, Stress (mechanics), 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Internal medicine, Medicine, 030211 gastroenterology & hepatology, business
Published
2018

18. 889 Micro-Inflammation and Overexpression of CaV3.2 Ion Channel in the Colonic Mucosa of IBS Patients: A Case-Control Study

Author

Scanzi, Julien, primary, Accarie, Alison, additional, Muller, Emilie, additional, Carvalho, Frederic A., additional, Pereira, Bruno, additional, Boudieu, Ludivine, additional, Gelot, Agathe, additional, Abergel, Armando, additional, Bommelaer, Gilles, additional, Eschalier, Alain, additional, Ardid, Denis, additional, and Dapoigny, Michel, additional

Published
2014
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19. 889 Micro-Inflammation and Overexpression of CaV3.2 Ion Channel in the Colonic Mucosa of IBS Patients: A Case-Control Study

Author

Julien Scanzi, Ludivine Boudieu, Bruno Pereira, Emilie Muller, Denis Ardid, Frederic A. Carvalho, Armando Abergel, Alison Accarie, Agathe Gelot, Michel Dapoigny, Gilles Bommelaer, and Alain Eschalier

Subjects
medicine.medical_specialty, Colonic mucosa, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Case-control study, Inflammation, medicine.symptom, business, Ion channel
Published
2014

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