1. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study
- Author
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Stephen J. Vanner, Iradj Maleki, Ammar Hassanzadeh Keshteli, Payman Adibi, Olafur S. Palsson, Dan L. Dumitrascu, Sandie R Thomson, Douglas A. Drossman, William E. Whitehead, Aurelio López-Colombo, Mashiko Setshedi, Max Schmulson, Yeong Yeh Lee, Bruno Bonaz, Oksana Stefanyuk, Jan Tack, Eamonn Martin Quigley, Enrico Corazziari, Valeria Costa, Edith N. Okeke, Magnus Simren, Timothy N. Archampong, John Kellow, Luis M. Bustos Fernandez, Uday C Ghoshal, Shrikant I. Bangdiwala, Nitesh Pratap, Viola Andresen, Motoyori Kanazawa, Suck Chei Choi, Rutaba Khatun, Leonid Lazebnik, Serhat Bor, Ram Dickman, M Masudur Rahman, Xuicai Fang, Pierre Poitras, Reuben K. Wong, Ami D. Sperber, Carlos Fernando de Magalhães Francisconi, Shin Fukudo, Peter J. Whorwell, Marc A. Benninga, Agata Mulak, Albis Hani, Javier Santos, Ari Fahrial Syam, Judith Zeevenhooven, Institut Català de la Salut, [Sperber AD] Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. [Bangdiwala SI] Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [Drossman DA] Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, North Carolina. [Ghoshal UC] Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India. [Simren M] Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [Tack J] Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium. [Santos J] Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Neuro-Inmuno-Gastroenterologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, and Ege Üniversitesi
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Adult ,Male ,atención a la salud (salud pública)::salud de grupos específicos::salud global [SALUD PÚBLICA] ,0301 basic medicine ,Patient-Reported Outcomes Measurement Information System ,medicine.medical_specialty ,Adolescent ,Gastrointestinal Diseases ,Other subheadings::Other subheadings::/epidemiology [Other subheadings] ,Global Health ,Enquestes ,Características de la Población::demografía::estadísticas vitales::morbilidad::prevalencia [ATENCIÓN DE SALUD] ,Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence [HEALTH CARE] ,Young Adult ,enfermedades del sistema digestivo::enfermedades gastrointestinales [ENFERMEDADES] ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Functional gastrointestinal disorder ,Quality of life ,Surveys and Questionnaires ,IBS ,Health care ,Epidemiology ,Prevalence ,Humans ,Medicine ,Sex Distribution ,Health Care (Public Health)::Health of Specific Groups::Global Health [PUBLIC HEALTH] ,Irritable bowel syndrome ,Aged ,Salut mundial ,DGBI ,Hepatology ,business.industry ,Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores] ,Gastroenterology ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,030104 developmental biology ,Female ,030211 gastroenterology & hepatology ,epidemiology ,Tracte gastrointestinal - Malalties - Epidemiologia ,Digestive System Diseases::Gastrointestinal Diseases [DISEASES] ,business ,Demography - Abstract
BACKGROUND & AIMS: Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. METHODS: Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. RESULTS: Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9-40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2-21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6-1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3-1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). CONCLUSIONS: in a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews., Ironwood; Shire; AllerganAllergan; TakedaTakeda Pharmaceutical Company Ltd; Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia [203.PPSP.6171192]; Takeda-Israel; Romanian Society of Neurogastroenterology, The study was funded, in part, by research grants from Ironwood, Shire, Allergan, and Takeda. The study in Malaysia was funded by the Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia (Reference: 203.PPSP.6171192). The study in Israel was funded by Takeda-Israel. The study in Romania was funded by the Romanian Society of Neurogastroenterology. None of the funders was involved in the planning, design, implementation, statistical analyses or any other aspect of the study including preparation of the paper or knowledge of its contents.
- Published
- 2021
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