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Your search keyword '"Jaimie D. Nathan"' showing total 27 results
Start Over Author "Jaimie D. Nathan" Journal gastroenterology
27 results on '"Jaimie D. Nathan"'

1. Fr339 PANCREATITIS AND OPIOID GENE VARIANTS ARE ASSOCIATED WITH PREOPERATIVE OPIOID USE: PRELIMINARY DATA FROM THE POST COHORT

Author

Sandra E. Safo, R. Matthew Walsh, Timothy L. Pruett, Piotr Witkowski, Luis F. Lara, Sri Prakash Mokshagundam, Varvara A. Kirchner, Guru Trikudanathan, Melena D. Bellin, Sarah Jane Schwarzenberg, Martin Wijkstrom, Martin L. Freeman, Timothy B. Gardner, Vikesh K. Singh, Jaimie D. Nathan, Maisam Abu-El-Haija, Katherine A. Morgan, Syed A. Ahmad, Srinath Chinnakotla, Andrew M. Posselt, Bashoo Naziruddin, Gregory J. Beilman, and Darwin L. Conwell

Subjects
Hepatology, Opioid, business.industry, Opioid use, Cohort, Gastroenterology, Medicine, Pancreatitis, business, medicine.disease, Bioinformatics, Gene, medicine.drug
Published
2021

2. Fr353 A LABEL-FREE INSULIN SENSOR USING MICROFLUIDIC-BASED RAMAN SPECTROSCOPY

Author

Appakalai N. Balamurugan, Deborah A. Elder, Jaimie D. Nathan, Tom K. Lin, Maisam Abu-El-Haija, Kyu Shik Mun, and Anjaparavanda P. Naren

Subjects
symbols.namesake, Materials science, Hepatology, Insulin, medicine.medical_treatment, Microfluidics, Gastroenterology, medicine, symbols, Nanotechnology, Raman spectroscopy, Label free
Published
2021

3. 300 QUALITY OF LIFE OUTCOMES IMPROVE POSTOPERATIVELY IN PEDIATRIC PATIENTS UNDERGOING TOTAL PANCREATECTOMY WITH ISLET AUTOTRANSPLANTATION

Author

Zishaan Farooqui, Todd M. Jenkins, Maisam Abu-El-Haija, Michael E. Johnston, Al-Faraaz Kassam, David S. Vitale, Alexander R. Cortez, Jaimie D. Nathan, and Tom K. Lin

Subjects
medicine.medical_specialty, geography, geography.geographical_feature_category, Hepatology, Total pancreatectomy, business.industry, medicine.medical_treatment, Gastroenterology, Islet, Autotransplantation, Surgery, Quality of life, medicine, business
Published
2021

4. 803 LONG TERM HEALTH-RELATED QUALITY OF LIFE OUTCOMES IN PEDIATRIC PATIENTS UNDERGOING TOTAL PANCREATECTOMY WITH ISLET AUTOTRANSPLANTATION

Author

Al-Faraaz Kassam, Michael E. Johnston, Jaimie D. Nathan, Maisam Abu-El-Haija, Alexander R. Cortez, and Tom K. Lin

Subjects
Health related quality of life, medicine.medical_specialty, geography, geography.geographical_feature_category, Hepatology, Total pancreatectomy, business.industry, medicine.medical_treatment, Gastroenterology, Islet, Autotransplantation, Term (time), Surgery, medicine, business
Published
2020

5. Mo1373 HUMAN PANCREAS-ON-A-CHIP TO STUDY PRESSURE-INDUCED PANCREATITIS

Author

Maisam Abu-El-Haija, Kyu Shik Mun, Anjaparavanda P. Naren, Rodger A. Liddle, and Jaimie D. Nathan

Subjects
Pathology, medicine.medical_specialty, Human pancreas, Hepatology, business.industry, Gastroenterology, medicine, Pancreatitis, medicine.disease, business
Published
2020

6. 183 TOTAL PANCREATECTOMY WITH ISLET AUTOTRANSPLANTATION REDUCES RESOURCE UTILIZATION IN PEDIATRIC PATIENTS

Author

Jaimie D. Nathan, Lin Fei, Tom K. Lin, Alexander R. Cortez, Maisam Abu-El-Haija, Huaiyu Zang, Michael E. Johnston, and Al-Faraaz Kassam

Subjects
medicine.medical_specialty, geography, geography.geographical_feature_category, Hepatology, business.industry, Total pancreatectomy, medicine.medical_treatment, Gastroenterology, Islet, Autotransplantation, Surgery, Medicine, business, Resource utilization
Published
2020

8. Su1441 – Association of Autoimmune Diseases in Children with Acute Recurrent Or Chronic Pancreatitis

Author

Douglas S. Fishman, Veronique D. Morinville, Tom K. Lin, Chee Y. Ooi, Michael Wilschanski, John F. Pohl, Bradley A. Barth, Steven D. Freedman, Emily R. Perito, David M. Troendle, Quin Liu, Jaimie D. Nathan, Mark E. Lowe, Maria R. Mascarenhas, Steven L. Werlin, Yuhua Zheng, Uzma Shah, Melena D. Bellin, Sarah Jane Schwarzenberg, Bridget Zimmerman, Sue Rhee, Tanja Gonska, Melvin B. Heyman, Brian A. McFerron, Aliye Uc, Ryan Himes, Maisam Abu-El-Haija, Asim Maqbool, Cheryl E. Gariepy, Matthew J. Giefer, and Sohail Z. Husain

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Pancreatitis, business, Association (psychology), medicine.disease
Published
2019

9. Sa1524 – Validation and Optimization of an Early Predictor Model for Pediatric Acute Pancreatitis

Author

Peter R Farrell, Maisam Abu-El-Haija, Lindsey Hornung, David S. Vitale, Ryan Pearman, Sona Sehgal, Beemnet Neway, Angelica W. DesPain, Jaimie D. Nathan, Tom K. Lin, Ashley Serrette, Esther Kim, and Peter F. Farmer

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Acute pancreatitis, business, medicine.disease
Published
2019

10. 729 – Sterility Cultures Following Pancreatectomy with Islet Autotransplantation in the Pediatric Population: Do They Matter?

Author

Lara Danziger-Isakov, Grant Paulsen, Jaimie D. Nathan, Maisam Abu-El-Haija, Alexander R. Cortez, Todd M. Jenkins, Tom K. Lin, and Al-Faraaz Kassam

Subjects
geography, medicine.medical_specialty, geography.geographical_feature_category, Hepatology, business.industry, Sterility, medicine.medical_treatment, Gastroenterology, Islet, Autotransplantation, Surgery, Pancreatectomy, Medicine, business, Pediatric population
Published
2019

12. 651 – International Study Group of Pediatric Pancreatitis: in Search for a Cure(INSPPIRE 2) Cohort Study: Design and Rationale from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Author

Douglas S. Fishman, Sarah Jane Schwarzenberg, Maria R. Mascarenhas, Brian A. McFerron, Tom K. Lin, John F. Pohl, Ryan Himes, Bradley A. Barth, Mel Heyman, Kate Ellery, Mark E. Lowe, Steven L. Werlin, Savitri Appana, Melena D. Bellin, Yuhua Zheng, David M. Troendle, Cheryl E. Gariepy, Matthew J. Giefer, Sohail Z. Husain, Zachary M. Sellers, Uzma Shah, Chee Y. Ooi, Asim Maqbool, Tanja Gonska, Ying Yuan, Emily R. Perito, Aliye Uc, Michael Wilschanski, Jaimie D. Nathan, Maisam Abu-El-Haija, Veronique D. Morinville, and José Ramón Serrano

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Diabetes mellitus, Pancreatic cancer, Gastroenterology, medicine, Pancreatitis, business, medicine.disease, Cohort study
Published
2019

13. Patient-Derived Pancreatic Ductal Organoids to Study CFTR Function

Author

Maisam Abu-El-Haija, Kyu Shik Mun, Kavisha Arora, Joseph J. Palermo, Jaimie D. Nathan, John P. Clancy, and Anjaparavanda P. Naren

Subjects
Hepatology, business.industry, Gastroenterology, Cancer research, Organoid, Medicine, Pancreatic carcinoma, business, Function (biology)
Published
2017

14. PRSS1 Mutations and Family History of Chronic Pancreatitis Predict Rapid Progression from Acute Recurrent to Chronic Pancreatitis in Childhood

Author

Steven L. Werlin, Cheryl E. Gariepy, Matthew J. Giefer, Ryan Himes, Aliye Uc, David A. Piccoli, Tom K. Lin, Jaimie D. Nathan, David M. Troendle, Emily R. Perito, Quin Liu, Tanja Gonska, Bradley A. Barth, Steven D. Freedman, Maria R. Mascarenhas, John F. Pohl, Mark E. Lowe, Uzma Shah, Sue Rhee, Douglas S. Fishman, Chee Y. Ooi, Bridget Zimmerman, Melena D. Bellin, Veronique D. Morinville, Maisam Abu-El-Haija, Sarah Jane Schwarzenberg, Joseph J. Palermo, Mel Heyman, Michael Wilschanski, Sohail Z. Husain, and Asim Maqbool

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Pancreatitis, Family history, business, medicine.disease
Published
2017

15. Tu1376 - Pediatric Chronic Pancreatitis without Prior Acute or Acute Recurrent Pancreatitis: A Report from Insppire Consortium

Author

Bridget Zimmerman, Zachary M. Sellers, Uzma Shah, Tom K. Lin, Jaimie D. Nathan, Melena D. Bellin, Sarah Jane Schwarzenberg, Maria Mascharenas, Michael Wilschanski, Bradley A. Barth, Yuhua Zheng, Brian A. McFerron, Melvin B. Heyman, Steven L. Werlin, Ryan Himes, Aliye Uc, Emily R. Perito, Cheryl E. Gariepy, Matthew J. Giefer, Tanja Gonska, Steven D. Freedman, Veronique D. Morinville, David M. Troendle, Quin Liu, Chee Y. Ooi, John F. Pohl, Maisam Abu-El-Haija, Douglas S. Fishman, Mark E. Lowe, Sohail Z. Husain, and Asim Maqbool

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Acute recurrent pancreatitis, Gastroenterology, medicine, Pancreatitis, business, medicine.disease
Published
2018

17. Mo1241 - Diabetes in Children with Acute Recurrent and Chronic Pancreatitis from the Insppire Cohort

Author

Uzma Shah, Steven D. Freedman, Maisam Abu-El-Haija, Bradley A. Barth, Yuhua Zheng, Cheryl E. Gariepy, Matthew J. Giefer, Tanja Gonska, David M. Troendle, Quin Liu, Brian A. McFerron, Jaimie D. Nathan, Sarah Jane Schwarzenberg, John F. Pohl, Ryan Himes, Sohail Z. Husain, Emily R. Perito, Chee Y. Ooi, Bridget Zimmerman, Zachary M. Sellers, Steven L. Werlin, Veronique D. Morinville, Maria R. Mascarenhas, Asim Maqbool, Douglas S. Fishman, Tom K. Lin, Michael Wilschanski, Mark E. Lowe, Melvin B. Heyman, Aliye Uc, and Melena D. Bellin

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Diabetes mellitus, Cohort, Gastroenterology, medicine, Pancreatitis, medicine.disease, business
Published
2018

18. Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice

Author

Michael Peyton, Rodger A. Liddle, Raymond J. MacDonald, Joelle Romac, Jaimie D. Nathan, and Ruth Y. Peng

Subjects
medicine.medical_specialty, Pancreatic Extracts, Trypsin inhibitor, Gene Expression, Mice, Inbred Strains, Mice, Transgenic, Mice, Internal medicine, medicine, Acinar cell, Animals, Trypsin, Transgenes, Trypsinogen activation, Pancreas, Pancreatic Secretory Trypsin Inhibitor, Staining and Labeling, Hepatology, Chemistry, Gastroenterology, medicine.disease, Rats, Microscopy, Electron, medicine.anatomical_structure, Endocrinology, Pancreatitis, Trypsin Inhibitor, Kazal Pancreatic, Immunologic Techniques, Intercellular Signaling Peptides and Proteins, Oligopeptides, Ceruletide, medicine.drug
Abstract

Endogenous trypsin inhibitors are believed to inhibit protease activity if trypsin becomes inadvertently activated within the acinar cell. However, this action remains unproven, and the role of endogenous pancreatic trypsin inhibitors in acute pancreatitis is unknown. In this study, we tested whether increased levels of pancreatic secretory trypsin inhibitor-I (PSTI-I) in mice could prevent secretagogue-induced pancreatitis.Rat PSTI-I expression was targeted to pancreatic acinar cells in transgenic mice by creating a minigene driven by the rat elastase I enhancer/promoter. Secretagogue-induced pancreatitis was achieved by 12 hourly intraperitoneal injections of caerulein. The severity of pancreatitis was assessed by measurements of serum amylase, histologic grading, and pancreas wet weight-to-body weight ratio. Trypsinogen activation and trypsin activity were measured in pancreatic extracts.Targeted expression of PSTI-I to the pancreas increased endogenous trypsin inhibitor capacity by 190% (P.01) in transgenic vs. nontransgenic mice. Caerulein administration to nontransgenic mice produced histologic evidence of acute pancreatitis, and significantly elevated serum amylase and pancreas weight ratio. In caerulein-treated transgenic mice, the histologic severity of pancreatitis was significantly reduced. There was no difference in trypsinogen activation peptide levels between caerulein-treated transgenic and nontransgenic mice. However, trypsin activity was significantly lower in transgenic mice receiving caerulein compared with nontransgenic mice.These data demonstrate that the severity of secretagogue-induced pancreatitis is significantly ameliorated in mice with higher pancreatic levels of trypsin inhibitor. We propose that PSTI-I prevents pancreatitis by inhibiting the activity of trypsin, rather than by reducing trypsinogen activation.

Published
2005

19. Tu1464 Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis

Author

Mark E. Lowe, Sarah Jane Schwarzenberg, Veronique D. Morinville, Quin Y. Liu, Ryan Himes, Melena D. Bellin, Cheryl E. Gariepy, Mel Heyman, Sue Rhee, Matthew J. Giefer, Sohail Z. Husain, Jaimie D. Nathan, Tanja Gonska, Chee Y. Ooi, Maisam Abu-El-Haija, Bridget Zimmerman, Steven L. Werlin, Joseph J. Palermo, Douglas S. Fishman, Steven D. Freedman, John F. Pohl, Tom K. Lin, David M. Troendle, Aliye Uc, Bradley A. Barth, Michael Wilschanski, and Emily R. Perito

Subjects
medicine.medical_specialty, Pancreas divisum, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Pancreatitis, business, medicine.disease
Published
2016

21. CTRC G60G Variant is Common in Children with Acute Recurrent and Chronic Pancreatitis and Associated with Early-Onset Disease

Author

Maisam Abu-El-Haija, David A. Piccoli, Maria R. Mascarenhas, Uzma Shah, Jessica LaRusch, Steven D. Freedman, Mark E. Lowe, Steven L. Werlin, Tom K. Lin, Sarah Jane Schwarzenberg, Veronique D. Morinville, Douglas S. Fishman, Sue Rhee, David C. Whitcomb, John F. Pohl, David M. Troendle, Quin Liu, Sohail Z. Husain, Tanja Gonska, Mel Heyman, Emily R. Perito, Jaimie D. Nathan, Asim Maqbool, Ryan Himes, Bradley A. Barth, Bridget Zimmerman, Cheryl E. Gariepy, Matthew J. Giefer, Chee Y. Ooi, Michael Wilschanski, Joseph J. Palermo, Aliye Uc, and Melena D. Bellin

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Pancreatitis, Early onset disease, medicine.disease, business
Published
2017

22. 963 Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Author

Ryan Himes, Michael Wilschanski, Maisam Abu-El-Haija, Bradley A. Barth, Steven L. Werlin, Mel Heyman, Emily R. Perito, Tanja Gonska, Tom K. Lin, Douglas S. Fishman, Veronique D. Morinville, Bridget Zimmerman, Steven D. Freedman, Aliye Uc, Mark E. Lowe, David M. Troendle, John F. Pohl, Sarah Jane Schwarzenberg, Quin Y. Liu, Sue Rhee, Joseph J. Palermo, Cheryl E. Gariepy, Sohail Z. Husain, Matthew J. Giefer, Melena D. Bellin, Jaimie D. Nathan, and Chee Y. Ooi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Pancreatitis, medicine.disease, business, Obesity
Published
2016

23. Mo1359 Early Predictors of Severe Pancreatitis in Children

Author

Joseph J. Palermo, Jaimie D. Nathan, Lin Fei, Lindsey Hornung, Flora Szabo, Tom K. Lin, and Maisam Abu-El-Haija

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Pancreatitis, medicine.disease, business
Published
2015

26. Transgenic expression of pancreatic secretory trypsin inhibitor-I (PSTI-I) in mice protects against caerulein-induced chronic pancreatitis and reduces pancreatic fibrosis

Author

Rodger A. Liddle, Jaimie D. Nathan, Michael Peyton, Raymond J. MacDonald, Joelle Romac, Ruth Y. Peng, and Don C. Rockey

Subjects
medicine.medical_specialty, Hepatology, biology, business.industry, Transgene, Gastroenterology, medicine.disease, Endocrinology, PstI, Internal medicine, medicine, biology.protein, Pancreatitis, business, Pancreatic Secretory Trypsin Inhibitor, Pancreatic fibrosis
Published
2003

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