1. Incisional Ventral Hernia in Rats, Stable Gastric Pentadecapeptide Bpc 157, L-Name and L-Arginine
- Author
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Frane Pamuković, Predrag Sikiric, Alen Pajtak, Domagoj Drmic, Zdenko Bilic, Janoš Kodvanj, Sven Seiwerth, and Fedor Amić
- Subjects
medicine.medical_specialty ,Endocrinology ,Hepatology ,Arginine ,business.industry ,Internal medicine ,Ventral hernia ,Gastroenterology ,medicine ,Incisional Ventral Hernia ,BPC 157 ,L-Name ,L-Arginine ,Biomechanics ,business - Abstract
Aim. Incisional ventral hernia (IVH) formation has a unique biomechanical disturbance which can be described by "early wound failure" mechanism. Therefore, we suggest that stable gastric pentadecapeptide BPC 157 (used in trials: IBD ; now, multiple sclerosis) known to heal various internal and external wounds and muscle injuries and interact with NOsystem (Curr Med Chem 2012 ; 19(1):126-32 ; Curr Pharm Des 2011 ; 17(16):1612-32 ; Curr Pharm Des 2014 ; 20(7):1126-35) rescues IVH in rats. To demonstrate that that rescue of IVH is also a particular NO-system related effect, NOS- blocker L-NAME and NOS-substrate Larginine were also given alone and/or combined. Methods. Wistar Albino male rats underwent ingrained method (Ann Surg. 2004 Jul ; 240(1):179-86.) of early wound failure induction (satisfactory IVH incidence) received medication/kg (BPC 157 (10ug, 0.16ug/mL, 12mL/ day/rat, in drinking water), L-NAME (5mg/day), L-arginine (100mg/day) both intraperitoneally, alone and/or combined ; or drinking water only (controls)) through 14 days. IVH size, cutaneous wound healing (CVH) quality and intraabdominal adhesions (IA) were scored. Results: IVH size was 6.8±4.8mm in controls. BPC 157 exhibited size 0.8±1.9 (vs. control p
- Published
- 2017
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