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33 results on '"Jenkins, Mark"'

1. Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

Author

Wang, Xiaoliang, Huyghe, Jeroen R., Joo, Jihoon E., Georgeson, Peter, Arndt, Volker, Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Brezina, Stefanie, Burnett-Hartman, Andrea, Campbell, Peter T., Casey, Graham, Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chen, Xuechen, Conti, David V., Cremolini, Chiara, Diergaarde, Brenda, Figueiredo, Jane C., FitzGerald, Liesel M., Gago-Dominguez, Manuela, Gallinger, Steven, Giles, Graham G., Gsu, Andrea, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Harrison, Tabitha A., Hoffmeister, Michael, Keku, Temitope O., Kundaje, Anshul, Le Marchand, Loic, Lenz, Heinz-Josef, Li, Christopher I., Li, Li, Lin, Yi, Lindblom, Annika, Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Newton, Christina C., Obón-Santacana, Mireia, Ogino, Shuji, Pai, Rish K., Palmer, Julie R., Pearlman, Rachel, Pharoah, Paul D.P., Phipps, Amanda I., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Stadler, Zsofia K., Steinfelder, Robert S., Thibodeau, Stephen N., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weinstein, Stephanie J., White, Emily, Winship, Ingrid M., Wolk, Alicja, Gruber, Stephen B., Jenkins, Mark A., Mahmood, Khalid, Thomas, Minta, Qu, Conghui, Hsu, Li, Buchanan, Daniel D., and Peters, Ulrike

Published
2023
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2. Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects

Author

Guo, Xingyi, Lin, Weiqiang, Wen, Wanqing, Huyghe, Jeroen, Bien, Stephanie, Cai, Qiuyin, Harrison, Tabitha, Chen, Zhishan, Qu, Conghui, Bao, Jiandong, Long, Jirong, Yuan, Yuan, Wang, Fangqin, Bai, Mengqiu, Abecasis, Goncalo R., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buch, Stephan, Burnett-Hartman, Andrea, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cho, Sang Hee, Conti, David V., Chapelle, Albert de la, Feskens, Edith J.M., Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Gsur, Andrea, Guinter, Mark, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Hayes, Richard B., Hoffmeister, Michael, Kampman, Ellen, Kang, Hyun Min, Keku, Temitope O., Kim, Hyeong Rok, Le Marchand, Loic, Lee, Soo Chin, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane, Milne, Roger L., Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Nickerson, Deborah A., Offit, Kenneth, Pearlman, Rachel, Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Schumacher, Fredrick R., Slattery, Martha L., Su, Yu-Ru, Tangen, Catherine M., Ulrich, Cornelia M., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Wang, Xiaoliang, White, Emily, Wolk, Alicja, Woods, Michael O., Casey, Graham, Hsu, Li, Jenkins, Mark A., Gruber, Stephen B., Peters, Ulrike, and Zheng, Wei

Published
2021
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3. Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome

Author

Santa Cruz Guindalini, Rodrigo, Win, Aung Ko, Gulden, Cassandra, Lindor, Noralane M, Newcomb, Polly A, Haile, Robert W, Raymond, Victoria, Stoffel, Elena, Hall, Michael, Llor, Xavier, Ukaegbu, Chinedu I, Solomon, Ilana, Weitzel, Jeffrey, Kalady, Matthew, Blanco, Amie, Terdiman, Jonathan, Shuttlesworth, Gladis A, Lynch, Patrick M, Hampel, Heather, Lynch, Henry T, Jenkins, Mark A, Olopade, Olufunmilayo I, and Kupfer, Sonia S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Digestive Diseases, Rare Diseases, Colo-Rectal Cancer, Cancer, Prevention, Clinical Research, Genetics, Genetic Testing, Aetiology, 2.1 Biological and endogenous factors, Adaptor Proteins, Signal Transducing, Adenosine Triphosphatases, Adult, Black or African American, Age Factors, Aged, Aged, 80 and over, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Mismatch Repair, DNA Repair Enzymes, DNA-Binding Proteins, Family, Female, Humans, Incidence, Male, Middle Aged, Mismatch Repair Endonuclease PMS2, MutL Protein Homolog 1, MutS Homolog 2 Protein, Mutation, Nuclear Proteins, Retrospective Studies, Risk Factors, Sex Factors, African Descent, Colon Cancer, DNA Repair, Hereditary Non-Polyposis Colorectal Cancer, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsAfrican Americans (AAs) have the highest incidence of and mortality resulting from colorectal cancer (CRC) in the United States. Few data are available on genetic and nongenetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in mismatch repair (MMR) genes in AAs with the most common inherited CRC condition, Lynch syndrome. We aimed to characterize phenotype, mutation spectrum, and risk of CRC in AAs with Lynch syndrome.MethodsWe performed a retrospective study of AAs with mutations in MMR genes (MLH1, MSH2, MSH6, and PMS2) using databases from 13 US referral centers. We analyzed data on personal and family histories of cancer. Modified segregation analysis conditioned on ascertainment criteria was used to estimate age- and sex-specific CRC cumulative risk, studying members of the mutation-carrying families.ResultsWe identified 51 AA families with deleterious mutations that disrupt function of the MMR gene product: 31 in MLH1 (61%), 11 in MSH2 (21%), 3 in MSH6 (6%), and 6 in PMS2 (12%); 8 mutations were detected in more than 1 individual, and 11 have not been previously reported. In the 920 members of the 51 families with deleterious mutations, the cumulative risks of CRC at 80 years of age were estimated to be 36.2% (95% confidence interval [CI], 10.5%-83.9%) for men and 29.7% (95% CI, 8.31%-76.1%) for women. CRC risk was significantly higher among individuals with mutations in MLH1 or MSH2 (hazard ratio, 13.9; 95% CI, 3.44-56.5).ConclusionsWe estimate the cumulative risk for CRC in AAs with MMR gene mutations to be similar to that of individuals of European descent with Lynch syndrome. Two-thirds of mutations were found in MLH1, some of which were found in multiple individuals and some that have not been previously reported. Differences in mutation spectrum are likely to reflect the genetic diversity of this population.

Published
2015

4. Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer

Author

Lu, Yingchang, Kweon, Sun-Seog, Tanikawa, Chizu, Jia, Wei-Hua, Xiang, Yong-Bing, Cai, Qiuyin, Zeng, Chenjie, Schmit, Stephanie L., Shin, Aesun, Matsuo, Keitaro, Jee, Sun Ha, Kim, Dong-Hyun, Kim, Jeongseon, Wen, Wanqing, Shi, Jiajun, Guo, Xingyi, Li, Bingshan, Wang, Nan, Zhang, Ben, Li, Xinxiang, Shin, Min-Ho, Li, Hong-Lan, Ren, Zefang, Oh, Jae Hwan, Oze, Isao, Ahn, Yoon-Ok, Jung, Keum Ji, Conti, David V., Schumacher, Fredrick R., Rennert, Gad, Jenkins, Mark A., Campbell, Peter T., Hoffmeister, Michael, Casey, Graham, Gruber, Stephen B., Gao, Jing, Gao, Yu-Tang, Pan, Zhi-Zhong, Kamatani, Yoichiro, Zeng, Yi-Xin, Shu, Xiao-Ou, Long, Jirong, Matsuda, Koichi, and Zheng, Wei

Published
2019
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5. Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

Author

Mahmood, Khalid, primary, Thomas, Minta, additional, Qu, Conghui, additional, Hsu, Li, additional, Buchanan, Daniel D., additional, Peters, Ulrike, additional, Wang, Xiaoliang, additional, Huyghe, Jeroen R., additional, Joo, Jihoon E., additional, Georgeson, Peter, additional, Arndt, Volker, additional, Berndt, Sonja I., additional, Bézieau, Stéphane, additional, Bien, Stephanie A., additional, Bishop, D. Timothy, additional, Brenner, Hermann, additional, Brezina, Stefanie, additional, Burnett-Hartman, Andrea, additional, Campbell, Peter T., additional, Casey, Graham, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chen, Xuechen, additional, Conti, David V., additional, Cremolini, Chiara, additional, Diergaarde, Brenda, additional, Figueiredo, Jane C., additional, FitzGerald, Liesel M., additional, Gago-Dominguez, Manuela, additional, Gallinger, Steven, additional, Giles, Graham G., additional, Gsu, Andrea, additional, Gunter, Marc J., additional, Hampe, Jochen, additional, Hampel, Heather, additional, Harrison, Tabitha A., additional, Hoffmeister, Michael, additional, Keku, Temitope O., additional, Kundaje, Anshul, additional, Le Marchand, Loic, additional, Lenz, Heinz-Josef, additional, Li, Christopher I., additional, Li, Li, additional, Lin, Yi, additional, Lindblom, Annika, additional, Moreno, Victor, additional, Murphy, Neil, additional, Newcomb, Polly A., additional, Newton, Christina C., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Pai, Rish K., additional, Palmer, Julie R., additional, Pearlman, Rachel, additional, Pharoah, Paul D.P., additional, Phipps, Amanda I., additional, Platz, Elizabeth A., additional, Potter, John D., additional, Rennert, Gad, additional, Sakoda, Lori C., additional, Schafmayer, Clemens, additional, Schmit, Stephanie L., additional, Schoen, Robert E., additional, Slattery, Martha L., additional, Stadler, Zsofia K., additional, Steinfelder, Robert S., additional, Thibodeau, Stephen N., additional, Ulrich, Cornelia M., additional, Um, Caroline Y., additional, van Duijnhoven, Franzel J.B., additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Weinstein, Stephanie J., additional, White, Emily, additional, Winship, Ingrid M., additional, Wolk, Alicja, additional, Gruber, Stephen B., additional, and Jenkins, Mark A., additional

Published
2023
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6. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis

Author

Peters, Ulrike, Jiao, Shuo, Schumacher, Fredrick R, Hutter, Carolyn M, Aragaki, Aaron K, Baron, John A, Berndt, Sonja I, Bézieau, Stéphane, Brenner, Hermann, Butterbach, Katja, Caan, Bette J, Campbell, Peter T, Carlson, Christopher S, Casey, Graham, Chan, Andrew T, Chang–Claude, Jenny, Chanock, Stephen J, Chen, Lin S, Coetzee, Gerhard A, Coetzee, Simon G, Conti, David V, Curtis, Keith R, Duggan, David, Edwards, Todd, Fuchs, Charles S, Gallinger, Steven, Giovannucci, Edward L, Gogarten, Stephanie M, Gruber, Stephen B, Haile, Robert W, Harrison, Tabitha A, Hayes, Richard B, Henderson, Brian E, Hoffmeister, Michael, Hopper, John L, Hudson, Thomas J, Hunter, David J, Jackson, Rebecca D, Jee, Sun Ha, Jenkins, Mark A, Jia, Wei–Hua, Kolonel, Laurence N, Kooperberg, Charles, Küry, Sébastien, LaCroix, Andrea Z, Laurie, Cathy C, Laurie, Cecelia A, Le Marchand, Loic, Lemire, Mathieu, Levine, David, Lindor, Noralane M, Liu, Yan, Ma, Jing, Makar, Karen W, Matsuo, Keitaro, Newcomb, Polly A, Potter, John D, Prentice, Ross L, Qu, Conghui, Rohan, Thomas, Rosse, Stephanie A, Schoen, Robert E, Seminara, Daniela, Shrubsole, Martha, Shu, Xiao–Ou, Slattery, Martha L, Taverna, Darin, Thibodeau, Stephen N, Ulrich, Cornelia M, White, Emily, Xiang, Yongbing, Zanke, Brent W, Zeng, Yi–Xin, Zhang, Ben, Zheng, Wei, Hsu, Li, and Registry, Genetics and Epidemiology of Colorectal Cancer Consortium Colon Cancer Family

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Digestive Diseases, Prevention, Genetics, Cancer, Colo-Rectal Cancer, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Age Distribution, Aged, Aged, 80 and over, Colorectal Neoplasms, Cyclin D2, DNA-Binding Proteins, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Incidence, Laminin, Male, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Risk Assessment, Sex Distribution, T-Box Domain Proteins, Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsHeritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis.MethodsWe conducted a genome-wide association study that included 14 studies, 12,696 cases of colorectal tumors (11,870 cancer, 826 adenoma), and 15,113 controls of European descent. The 10 most statistically significant, previously unreported findings were followed up in 6 studies; these included 3056 colorectal tumor cases (2098 cancer, 958 adenoma) and 6658 controls of European and Asian descent.ResultsBased on the combined analysis, we identified a locus that reached the conventional genome-wide significance level at less than 5.0 × 10(-8): an intergenic region on chromosome 2q32.3, close to nucleic acid binding protein 1 (most significant single nucleotide polymorphism: rs11903757; odds ratio [OR], 1.15 per risk allele; P = 3.7 × 10(-8)). We also found evidence for 3 additional loci with P values less than 5.0 × 10(-7): a locus within the laminin gamma 1 gene on chromosome 1q25.3 (rs10911251; OR, 1.10 per risk allele; P = 9.5 × 10(-8)), a locus within the cyclin D2 gene on chromosome 12p13.32 (rs3217810 per risk allele; OR, 0.84; P = 5.9 × 10(-8)), and a locus in the T-box 3 gene on chromosome 12q24.21 (rs59336; OR, 0.91 per risk allele; P = 3.7 × 10(-7)).ConclusionsIn a large genome-wide association study, we associated polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-binding protein involved in DNA repair) with colorectal tumor risk. We also provided evidence for an association between colorectal tumor risk and polymorphisms in laminin gamma 1 (this is the second gene in the laminin family to be associated with colorectal cancers), cyclin D2 (which encodes for cyclin D2), and T-box 3 (which encodes a T-box transcription factor and is a target of Wnt signaling to β-catenin). The roles of these genes and their products in cancer pathogenesis warrant further investigation.

Published
2013

7. Quantitative Pathologic Analysis of Digitized Images of Colorectal Carcinoma Improves Prediction of Recurrence-Free Survival

Author

Pai, Reetesh K., primary, Banerjee, Imon, additional, Shivji, Sameer, additional, Jain, Suchit, additional, Hartman, Douglas, additional, Buchanan, Daniel D., additional, Jenkins, Mark A., additional, Schaeffer, David F., additional, Rosty, Christophe, additional, Como, Julia, additional, Phipps, Amanda I., additional, Newcomb, Polly A., additional, Burnett-Hartman, Andrea N., additional, Le Marchand, Loic, additional, Samadder, Niloy J., additional, Patel, Bhavik, additional, Swallow, Carol, additional, Lindor, Noralane M., additional, Gallinger, Steven J., additional, Grant, Robert C., additional, Westerling-Bui, Thomas, additional, Conner, James, additional, Cyr, David P., additional, Kirsch, Richard, additional, and Pai, Rish K., additional

Published
2022
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10. 92 USE OF DEEP LEARNING TO EVALUATE TUMOR MORPHOLOGICAL FEATURES FOR PREDICTION OF COLON CANCER RECURRENCE

Author

Ardestani, Bahar Saberzadeh, Nelson, Garth D., Segovia, Diana I., Graham, Rondell, Wu, Christina, Hagen, Catherine E., Shivji, Sameer, Savage, Paul, Buchanan, Daniel, Jenkins, Mark, Phipps, Amanda, Swallow, Carol, La Marchand, Loic, Gallinger, Steven, Grant, Robert C., Pai, Reet, Sinicrope, Stephen N., Yan, Dongyao, Shanmugam, Kandavel, Connor, James, Cyr, David, Kirsch, Richard, Banerjee, Imon, Alberts, Steven R., Shi, Qian, Pai, Rish, and Sinicrope, Frank A.

Published
2024
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13. Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer

Author

Elsayed, Fadwa A., primary, Grolleman, Judith E., additional, Ragunathan, Abiramy, additional, Buchanan, Daniel D., additional, van Wezel, Tom, additional, de Voer, Richarda M., additional, Boot, Arnoud, additional, Stojovska, Marija Staninova, additional, Mahmood, Khalid, additional, Clendenning, Mark, additional, de Miranda, Noel, additional, Dymerska, Dagmara, additional, Egmond, Demi van, additional, Gallinger, Steven, additional, Georgeson, Peter, additional, Hoogerbrugge, Nicoline, additional, Hopper, John L., additional, Jansen, Erik A.M., additional, Jenkins, Mark A., additional, Joo, Jihoon E., additional, Kuiper, Roland P., additional, Ligtenberg, Marjolijn J.L., additional, Lubinski, Jan, additional, Macrae, Finlay A., additional, Morreau, Hans, additional, Newcomb, Polly, additional, Nielsen, Maartje, additional, Palles, Claire, additional, Park, Daniel J., additional, Pope, Bernard J., additional, Rosty, Christophe, additional, Ruiz Ponte, Clara, additional, Schackert, Hans K., additional, Sijmons, Rolf H., additional, Tomlinson, Ian P., additional, Tops, Carli M.J., additional, Vreede, Lilian, additional, Walker, Romy, additional, and Win, Aung K., additional

Published
2020
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14. Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies

Author

Phipps, Amanda I., primary, Alwers, Elizabeth, additional, Harrison, Tabitha, additional, Banbury, Barbara, additional, Brenner, Hermann, additional, Campbell, Peter T., additional, Chang-Claude, Jenny, additional, Buchanan, Daniel, additional, Chan, Andrew T., additional, Farris, Alton B., additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Jenkins, Mark, additional, Milne, Roger L., additional, Newcomb, Polly A., additional, Slattery, Martha L., additional, Song, Mingyang, additional, Ogino, Shuji, additional, Zaidi, Syed H., additional, Hoffmeister, Michael, additional, and Peters, Ulrike, additional

Published
2020
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15. 1015 INTEGRATIVE MOLECULAR MARKER ANALYSES OF EARLY-ONSET COLORECTAL CANCER SUPPORT THE IMPORTANCE OF THE TRADITIONAL ADENOMA-CARCINOMA SEQUENCE

Author

Cao, Yin, primary, Harrison, Tabitha, additional, Liu, Jie, additional, Qu, Conghui, additional, Zong, Xiaoyu, additional, Alwers, Elizabeth, additional, Brenner, Hermann, additional, Buchanan, Daniel, additional, Campbell, Peter, additional, Chang-Claude, Jenny, additional, Giles, Graham G., additional, Gunter, Marc, additional, Jenkins, Mark, additional, Schoen, Robert E., additional, Slattery, Martha, additional, Van Guelpen, Bethany, additional, Woods, Michael, additional, Hsu, Li, additional, Hoffmeister, Michael, additional, Newcomb, Polly, additional, Peters, Ulrike, additional, and Chan, Andrew T., additional

Published
2020
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16. Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Author

Archambault, Alexi N., primary, Su, Yu-Ru, additional, Jeon, Jihyoun, additional, Thomas, Minta, additional, Lin, Yi, additional, Conti, David V., additional, Win, Aung Ko, additional, Sakoda, Lori C., additional, Lansdorp-Vogelaar, Iris, additional, Peterse, Elisabeth F.P., additional, Zauber, Ann G., additional, Duggan, David, additional, Holowatyj, Andreana N., additional, Huyghe, Jeroen R., additional, Brenner, Hermann, additional, Cotterchio, Michelle, additional, Bézieau, Stéphane, additional, Schmit, Stephanie L., additional, Edlund, Christopher K., additional, Southey, Melissa C., additional, MacInnis, Robert J., additional, Campbell, Peter T., additional, Chang-Claude, Jenny, additional, Slattery, Martha L., additional, Chan, Andrew T., additional, Joshi, Amit D., additional, Song, Mingyang, additional, Cao, Yin, additional, Woods, Michael O., additional, White, Emily, additional, Weinstein, Stephanie J., additional, Ulrich, Cornelia M., additional, Hoffmeister, Michael, additional, Bien, Stephanie A., additional, Harrison, Tabitha A., additional, Hampe, Jochen, additional, Li, Christopher I., additional, Schafmayer, Clemens, additional, Offit, Kenneth, additional, Pharoah, Paul D., additional, Moreno, Victor, additional, Lindblom, Annika, additional, Wolk, Alicja, additional, Wu, Anna H., additional, Li, Li, additional, Gunter, Marc J., additional, Gsur, Andrea, additional, Keku, Temitope O., additional, Pearlman, Rachel, additional, Bishop, D. Timothy, additional, Castellví-Bel, Sergi, additional, Moreira, Leticia, additional, Vodicka, Pavel, additional, Kampman, Ellen, additional, Giles, Graham G., additional, Albanes, Demetrius, additional, Baron, John A., additional, Berndt, Sonja I., additional, Brezina, Stefanie, additional, Buch, Stephan, additional, Buchanan, Daniel D., additional, Trichopoulou, Antonia, additional, Severi, Gianluca, additional, Chirlaque, María-Dolores, additional, Sánchez, Maria-José, additional, Palli, Domenico, additional, Kühn, Tilman, additional, Murphy, Neil, additional, Cross, Amanda J., additional, Burnett-Hartman, Andrea N., additional, Chanock, Stephen J., additional, de la Chapelle, Albert, additional, Easton, Douglas F., additional, Elliott, Faye, additional, English, Dallas R., additional, Feskens, Edith J.M., additional, FitzGerald, Liesel M., additional, Goodman, Phyllis J., additional, Hopper, John L., additional, Hudson, Thomas J., additional, Hunter, David J., additional, Jacobs, Eric J., additional, Joshu, Corinne E., additional, Küry, Sébastien, additional, Markowitz, Sanford D., additional, Milne, Roger L., additional, Platz, Elizabeth A., additional, Rennert, Gad, additional, Rennert, Hedy S., additional, Schumacher, Fredrick R., additional, Sandler, Robert S., additional, Seminara, Daniela, additional, Tangen, Catherine M., additional, Thibodeau, Stephen N., additional, Toland, Amanda E., additional, van Duijnhoven, Franzel J.B., additional, Visvanathan, Kala, additional, Vodickova, Ludmila, additional, Potter, John D., additional, Männistö, Satu, additional, Weigl, Korbinian, additional, Figueiredo, Jane, additional, Martín, Vicente, additional, Larsson, Susanna C., additional, Parfrey, Patrick S., additional, Huang, Wen-Yi, additional, Lenz, Heinz-Josef, additional, Castelao, Jose E., additional, Gago-Dominguez, Manuela, additional, Muñoz-Garzón, Victor, additional, Mancao, Christoph, additional, Haiman, Christopher A., additional, Wilkens, Lynne R., additional, Siegel, Erin, additional, Barry, Elizabeth, additional, Younghusband, Ban, additional, Van Guelpen, Bethany, additional, Harlid, Sophia, additional, Zeleniuch-Jacquotte, Anne, additional, Liang, Peter S., additional, Du, Mengmeng, additional, Casey, Graham, additional, Lindor, Noralane M., additional, Le Marchand, Loic, additional, Gallinger, Steven J., additional, Jenkins, Mark A., additional, Newcomb, Polly A., additional, Gruber, Stephen B., additional, Schoen, Robert E., additional, Hampel, Heather, additional, Corley, Douglas A., additional, Hsu, Li, additional, Peters, Ulrike, additional, and Hayes, Richard B., additional

Published
2020
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17. Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

Author

Murphy, Neil, primary, Carreras-Torres, Robert, additional, Song, Mingyang, additional, Chan, Andrew T., additional, Martin, Richard M., additional, Papadimitriou, Nikos, additional, Dimou, Niki, additional, Tsilidis, Konstantinos K., additional, Banbury, Barbara, additional, Bradbury, Kathryn E., additional, Besevic, Jelena, additional, Rinaldi, Sabina, additional, Riboli, Elio, additional, Cross, Amanda J., additional, Travis, Ruth C., additional, Agnoli, Claudia, additional, Albanes, Demetrius, additional, Berndt, Sonja I., additional, Bézieau, Stéphane, additional, Bishop, D. Timothy, additional, Brenner, Hermann, additional, Buchanan, Daniel D., additional, Onland-Moret, N. Charlotte, additional, Burnett-Hartman, Andrea, additional, Campbell, Peter T., additional, Casey, Graham, additional, Castellví-Bel, Sergi, additional, Chang-Claude, Jenny, additional, Chirlaque, María-Dolores, additional, de la Chapelle, Albert, additional, English, Dallas, additional, Figueiredo, Jane C., additional, Gallinger, Steven J., additional, Giles, Graham G., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Hampe, Jochen, additional, Hampel, Heather, additional, Harrison, Tabitha A., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Huang, Wen-Yi, additional, Huyghe, Jeroen R., additional, Jenkins, Mark A., additional, Keku, Temitope O., additional, Kühn, Tilman, additional, Kweon, Sun-Seog, additional, Le Marchand, Loic, additional, Li, Christopher I., additional, Li, Li, additional, Lindblom, Annika, additional, Martín, Vicente, additional, Milne, Roger L., additional, Moreno, Victor, additional, Newcomb, Polly A., additional, Offit, Kenneth, additional, Ogino, Shuji, additional, Ose, Jennifer, additional, Perduca, Vittorio, additional, Phipps, Amanda I., additional, Platz, Elizabeth A., additional, Potter, John D., additional, Qu, Conghui, additional, Rennert, Gad, additional, Sakoda, Lori C., additional, Schafmayer, Clemens, additional, Schoen, Robert E., additional, Slattery, Martha L., additional, Tangen, Catherine M., additional, Ulrich, Cornelia M., additional, van Duijnhoven, Franzel J.B., additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Wang, Hansong, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O., additional, Wu, Anna H., additional, Zheng, Wei, additional, Peters, Ulrike, additional, and Gunter, Marc J., additional

Published
2020
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18. 284 - Potential Impact of Family History Based Screening Guidelines on Early Cancer Detection Among Individuals at Risk for Young Onset Colorectal Cancer

Author

Gupta, Samir, primary, Bharti, Balambal, additional, Ahnen, Dennis, additional, Newcomb, Polly, additional, Jenkins, Mark, additional, Win, Aung Ko, additional, Buchanan, D, additional, Marchand, Loic La, additional, Lindor, Noralane, additional, Gallinger, Steven, additional, Cotterchio, Michelle, additional, Haile, Robert, additional, Figueiredo, Jane, additional, Cheng, Iona, additional, Thibodeau, Stephen, additional, and Martinez, Maria Elena, additional

Published
2018
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19. Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

Author

Zeng, Chenjie, primary, Matsuda, Koichi, additional, Jia, Wei-Hua, additional, Chang, Jiang, additional, Kweon, Sun-Seog, additional, Xiang, Yong-Bing, additional, Shin, Aesun, additional, Jee, Sun Ha, additional, Kim, Dong-Hyun, additional, Zhang, Ben, additional, Cai, Qiuyin, additional, Guo, Xingyi, additional, Long, Jirong, additional, Wang, Nan, additional, Courtney, Regina, additional, Pan, Zhi-Zhong, additional, Wu, Chen, additional, Takahashi, Atsushi, additional, Shin, Min-Ho, additional, Matsuo, Keitaro, additional, Matsuda, Fumihiko, additional, Gao, Yu-Tang, additional, Oh, Jae Hwan, additional, Kim, Soriul, additional, Jung, Keum Ji, additional, Ahn, Yoon-Ok, additional, Ren, Zefang, additional, Li, Hong-Lan, additional, Wu, Jie, additional, Shi, Jiajun, additional, Wen, Wanqing, additional, Yang, Gong, additional, Li, Bingshan, additional, Ji, Bu-Tian, additional, Brenner, Hermann, additional, Schoen, Robert E., additional, Küry, Sébastien, additional, Gruber, Stephen B., additional, Schumacher, Fredrick R., additional, Stenzel, Stephanie L., additional, Casey, Graham, additional, Hopper, John L., additional, Jenkins, Mark A., additional, Kim, Hyeong-Rok, additional, Jeong, Jin-Young, additional, Park, Ji Won, additional, Tajima, Kazuo, additional, Cho, Sang-Hee, additional, Kubo, Michiaki, additional, Shu, Xiao-Ou, additional, Lin, Dongxin, additional, Zeng, Yi-Xin, additional, Zheng, Wei, additional, Baron, John A., additional, Berndt, Sonja I., additional, Bezieau, Stéphane, additional, Caan, Bette J., additional, Carlson, Christopher S., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Conti, David V., additional, Curtis, Keith, additional, Duggan, David, additional, Fuchs, Charles S., additional, Gallinger, Steven, additional, Giovannucci, Edward L., additional, Haile, Robert W., additional, Harrison, Tabitha A., additional, Hayes, Richard B., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Hudson, Thomas J., additional, Hunter, David J., additional, Hutter, Carolyn M., additional, Jackson, Rebecca D., additional, Jiao, Shuo, additional, Le Marchand, Loic, additional, Lemire, Mathieu, additional, Lindor, Noralane M., additional, Ma, Jing, additional, Newcomb, Polly A., additional, Peters, Ulrike, additional, Potter, John D., additional, Qu, Conghui, additional, Seminara, Daniela, additional, Slattery, Martha L., additional, Thibodeau, Stephen N., additional, White, Emily, additional, Zanke, Brent W., additional, Blalock, Kendra, additional, Campbell, Peter T., additional, Edlund, Christopher K., additional, Figueiredo, Jane, additional, Gauderman, W. James, additional, Gong, Jian, additional, Green, Roger C., additional, Harju, John F., additional, Jacobs, Eric J., additional, Li, Li, additional, Lin, Yi, additional, Manion, Frank J., additional, Moreno, Victor, additional, Mukherjee, Bhramar, additional, Raskin, Leon, additional, Severi, Gianluca, additional, and Thomas, Duncan C., additional

Published
2016
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20. Mutation Spectrum and Risk of Colorectal Cancer in African American Families with Lynch Syndrome

Author

Guindalini, Rodrigo Santa Cruz, primary, Win, Aung Ko, additional, Gulden, Cassandra, additional, Lindor, Noralane M., additional, Newcomb, Polly A., additional, Haile, Robert W., additional, Raymond, Victoria, additional, Stoffel, Elena, additional, Hall, Michael, additional, Llor, Xavier, additional, Ukaegbu, Chinedu I., additional, Solomon, Ilana, additional, Weitzel, Jeffrey, additional, Kalady, Matthew, additional, Blanco, Amie, additional, Terdiman, Jonathan, additional, Shuttlesworth, Gladis A., additional, Lynch, Patrick M., additional, Hampel, Heather, additional, Lynch, Henry T., additional, Jenkins, Mark A., additional, Olopade, Olufunmilayo I., additional, and Kupfer, Sonia S., additional

Published
2015
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22. 720 Rare Variants in CRC Susceptibility Genes Do Not Predispose to Serrated Polyposis Syndrome

Author

Clendenning, Mark, primary, Crawford, William J., additional, Woodall, Sonja, additional, Arnold, Julie, additional, Sweet, Kevin, additional, Nagler, Belinda N., additional, Walters, Rhiannon J., additional, Win, Aung Ko, additional, Jenkins, Mark A., additional, Hopper, John, additional, Aronson, Melyssa, additional, Gallinger, Steven, additional, Young, Joanne, additional, Rosty, Christophe, additional, Parry, Susan, additional, and Buchanan, Daniel D., additional

Published
2014
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23. Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer

Author

Win, Aung Ko, primary, Dowty, James G., additional, Cleary, Sean P., additional, Kim, Hyeja, additional, Buchanan, Daniel D., additional, Young, Joanne P., additional, Clendenning, Mark, additional, Rosty, Christophe, additional, MacInnis, Robert J., additional, Giles, Graham G., additional, Boussioutas, Alex, additional, Macrae, Finlay A., additional, Parry, Susan, additional, Goldblatt, Jack, additional, Baron, John A., additional, Burnett, Terrilea, additional, Le Marchand, Loïc, additional, Newcomb, Polly A., additional, Haile, Robert W., additional, Hopper, John L., additional, Cotterchio, Michelle, additional, Gallinger, Steven, additional, Lindor, Noralane M., additional, Tucker, Katherine M., additional, Winship, Ingrid M., additional, and Jenkins, Mark A., additional

Published
2014
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25. Su1851 Family History and Pathology Features in Early-Onset Colorectal Cancer Cases With a BRAF P.V600e Mutation

Author

Buchanan, Daniel D., primary, Win, Aung Ko, additional, Walters, Rhiannon J., additional, Walsh, Michael D., additional, Clendenning, Mark, additional, Nagler, Belinda N., additional, Pavluk, Erika, additional, Pearson, Sally-Ann, additional, Rosty, Christophe, additional, Parry, Susan, additional, Hopper, John, additional, Jenkins, Mark A., additional, and Young, Joanne P., additional

Published
2012
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26. 822a Metachronous Colorectal Cancer Risk Following Surgery for First Rectal Cancer in Mismatch Repair Gene Mutation Carriers

Author

Win, Aung Ko, primary, Parry, Susan, additional, Parry, Bryan, additional, Kalady, Matthew F., additional, Macrae, Finlay A., additional, Lindor, Noralane M., additional, Haile, Robert W., additional, Newcomb, Polly A., additional, Marchand, Loïc Le, additional, Gallinger, Steven, additional, Hopper, John, additional, and Jenkins, Mark A., additional

Published
2012
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27. Mo1607 Role of Environmental Risk Factors on Early-Onset Colorectal Cancer Risk

Author

Win, Aung Ko, primary, Taunde, Sergio A., additional, Young, Joanne P., additional, Buchanan, Daniel D., additional, Ouakrim, Driss Ait, additional, Lindor, Noralane M., additional, Le Marchand, Loíc, additional, Gallinger, Steven, additional, Cotterchio, Michelle, additional, Newcomb, Polly A., additional, Haile, Robert W., additional, Hopper, John, additional, and Jenkins, Mark A., additional

Published
2012
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28. The PREMM1,2,6 Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History

Author

Kastrinos, Fay, primary, Steyerberg, Ewout W., additional, Mercado, Rowena, additional, Balmaña, Judith, additional, Holter, Spring, additional, Gallinger, Steven, additional, Siegmund, Kimberly D., additional, Church, James M., additional, Jenkins, Mark A., additional, Lindor, Noralane M., additional, Thibodeau, Stephen N., additional, Burbidge, Lynn Anne, additional, Wenstrup, Richard J., additional, and Syngal, Sapna, additional

Published
2011
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30. S1677 Over-Expression of the Chromosome 11 Mucins is Associated With CIMP and BRAF Mutation in Colorectal Cancer

Author

Walsh, Michael D., primary, Buchanan, Daniel D., additional, Pearson, Sally-Ann, additional, Walters, Rhiannon J., additional, McKeone, Diane M., additional, Clendenning, Mark, additional, Hopper, John, additional, Jenkins, Mark A., additional, Giles, Graham G., additional, English, Dallas, additional, Rosty, Christophe, additional, McGuckin, Michael A., additional, and Young, Joanne P., additional

Published
2010
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31. Germline MutY Human Homologue Mutations and Colorectal Cancer: A Multisite Case-Control Study

Author

Cleary, Sean P., primary, Cotterchio, Michelle, additional, Jenkins, Mark A., additional, Kim, Hyeja, additional, Bristow, Robert, additional, Green, Roger, additional, Haile, Robert, additional, Hopper, John L., additional, LeMarchand, Loic, additional, Lindor, Noralane, additional, Parfrey, Patrick, additional, Potter, John, additional, Younghusband, Ban, additional, and Gallinger, Steven, additional

Published
2009
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32. The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations

Author

Senter, Leigha, primary, Clendenning, Mark, additional, Sotamaa, Kaisa, additional, Hampel, Heather, additional, Green, Jane, additional, Potter, John D., additional, Lindblom, Annika, additional, Lagerstedt, Kristina, additional, Thibodeau, Stephen N., additional, Lindor, Noralane M., additional, Young, Joanne, additional, Winship, Ingrid, additional, Dowty, James G., additional, White, Darren M., additional, Hopper, John L., additional, Baglietto, Laura, additional, Jenkins, Mark A., additional, and de la Chapelle, Albert, additional

Published
2008
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33. Pathology Features in Bethesda Guidelines Predict Colorectal Cancer Microsatellite Instability: A Population-Based Study

Author

Jenkins, Mark A., primary, Hayashi, Shinichi, additional, O’Shea, Anne-Marie, additional, Burgart, Lawrence J., additional, Smyrk, Tom C., additional, Shimizu, David, additional, Waring, Paul M., additional, Ruszkiewicz, Andrew R., additional, Pollett, Aaron F., additional, Redston, Mark, additional, Barker, Melissa A., additional, Baron, John A., additional, Casey, Graham R., additional, Dowty, James G., additional, Giles, Graham G., additional, Limburg, Paul, additional, Newcomb, Polly, additional, Young, Joanne P., additional, Walsh, Michael D., additional, Thibodeau, Stephen N., additional, Lindor, Noralane M., additional, LeMarchand, Loïc, additional, Gallinger, Steven, additional, Haile, Robert W., additional, Potter, John D., additional, Hopper, John L., additional, and Jass, Jeremy R., additional

Published
2007
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