1. Human chorionic gonadotropin in normal, inflammatory, and carcinomatous gastric tissue
- Author
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Misato Adachi, Kazuhiro Hirao, and Toshiaki Manabe
- Subjects
Adult ,Gastritis, Atrophic ,Male ,endocrine system ,medicine.medical_specialty ,Pathology ,Adenocarcinoma ,Biology ,Chorionic Gonadotropin ,Human chorionic gonadotropin ,Immunoenzyme Techniques ,Stomach Neoplasms ,Internal medicine ,medicine ,Gastric mucosa ,Carcinoma ,Humans ,Chorionic Gonadotropin, beta Subunit, Human ,Stomach Ulcer ,reproductive and urinary physiology ,Aged ,Hepatology ,Histocytochemistry ,Stomach ,digestive, oral, and skin physiology ,Gastroenterology ,Cancer ,Middle Aged ,medicine.disease ,Pylorus ,Adenocarcinoma, Mucinous ,Peptide Fragments ,digestive system diseases ,medicine.anatomical_structure ,Endocrinology ,Gastric Mucosa ,embryonic structures ,Carcinoma, Squamous Cell ,Female ,Gastritis ,medicine.symptom - Abstract
Tissues from 12 patients with gastric ulcers, 50 patients with gastric carcinoma, and 2 normal subjects who died suddenly were examined immunohistochemically with antiserum against the beta-subunit of human chorionic gonadotropin. Human chorionic gonadotropin-beta-immunoreactive cells were present in the neck portion of the pyloric and pseudopyloric glands of normal and inflammatory gastric tissue. Gastric cancers located in the antrum-pylorus and the cardia were frequently associated with human chorionic gonadotropin immunoreactivity. These findings indicate that human chorionic gonadotropin-producing cells normally exist in the gastric mucosa, especially in the pylorus. It is speculated that normal human chorionic gonadotropin-producing cells may give rise to cancer in certain cases.
- Published
- 1985
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