11 results on '"Sabela Carballal"'
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2. White-Light Endoscopy Is Adequate for Lynch Syndrome Surveillance in a Randomized and Noninferiority Study
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María López-Cerón, Antonio Z. Gimeno-García, Ariadna Sánchez, Sofía Parejo, Victoria Alvarez, Liseth Rivero-Sánchez, Beatriz Peñas, David Remedios, Joaquín Cubiella, Cristina Rodríguez de Miguel, Gerhard Jung, Patricia Calvo, Cristina Carretero, Alain Huerta, Maite Herraiz, Teresa Ocaña, Jorge López-Vicente, Leticia Moreira, Jordi Gordillo, Esteban Saperas, Maria Pellise, Antoni Castells, Rebeca Moreira, Cristina Alvarez-Urturi, Jesús Herrero, Sabela Carballal, Eduardo Albéniz, Josep Llach, Francesc Balaguer, Inmaculada Salces, Ignasi Puig, Marta García-Cougil, Coral Arnau-Collell, and Enrique Rodríguez de Santiago
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0301 basic medicine ,Adenoma ,Adult ,Male ,medicine.medical_specialty ,ADR ,Colorectal cancer ,Colonoscopy ,Gastroenterology ,Chromoendoscopy ,03 medical and health sciences ,Polyp ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Panchromoendoscopy ,Prospective Studies ,Prospective cohort study ,Early Detection of Cancer ,Hepatology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,Confidence interval ,Lynch syndrome ,CRC ,Endoscopy ,030104 developmental biology ,Population Surveillance ,030211 gastroenterology & hepatology ,Female ,business ,Colorectal Neoplasms - Abstract
Background & Aims Dye-based pancolonic chromoendoscopy is recommended for colorectal cancer surveillance in patients with Lynch syndrome. However, there is scarce evidence to support its superiority to high-definition white-light endoscopy. We performed a prospective study assess whether in the hands of high detecting colonoscopists, high-definition, white-light endoscopy is noninferior to pancolonic chromoendoscopy for detection of adenomas in patients with Lynch syndrome. Methods We conducted a parallel controlled study, from July 2016 through January 2018 at 14 centers in Spain of adults with pathogenic germline variants in mismatch repair genes (60% women; mean age, 47 ± 14 years) under surveillance. Patients were randomly assigned to groups that underwent high-definition white-light endoscopy (n = 128) or pancolonic chromoendoscopy (n = 128) evaluations by 24 colonoscopists who specialized in detection of colorectal lesions in high-risk patients for colorectal cancer. Adenoma detection rates (defined as the proportion of patients with at least 1 adenoma) were compared between groups, with a noninferiority margin (relative difference) of 15%. Results We found an important overlap of confidence intervals (CIs) and no significant difference in adenoma detection rates by pancolonic chromoendoscopy (34.4%; 95% CI 26.4%–43.3%) vs white-light endoscopy (28.1%; 95% CI 21.1%–36.4%; P = .28). However, pancolonic chromoendoscopy detected serrated lesions in a significantly higher proportion of patients (37.5%; 95% CI 29.5–46.1) than white-light endoscopy (23.4%; 95% CI 16.9–31.4; P = .01). However, there were no significant differences between groups in proportions of patients found to have serrated lesions of 5 mm or larger (9.4% vs 7.0%; P = .49), of proximal location (11.7% vs 10.2%; P = .68), or sessile serrated lesions (3.9% vs 5.5%; P = .55), respectively. Total procedure and withdrawal times with pancolonic chromoendoscopy (30.7 ± 12.8 minutes and 18.3 ± 7.6 minutes, respectively) were significantly longer than with white-light endoscopy (22.4 ± 8.7 minutes and 13.5 ± 5.6 minutes; P Conclusions In a randomized parallel trial, we found that for Lynch syndrome surveillance, high-definition white-light endoscopy is not inferior to pancolonic chromoendoscopy if performed by experienced and dedicated endoscopists. ClinicalTrials.gov no: NCT02951390.
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- 2019
3. 598 POST-COLONOSCOPY COLORECTAL CANCER IN LYNCH SYNDROME IS ASSOCIATED WITH QUALITY ISSUES DURING SURVEILLANCE
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Adolfo Suárez, Esteban Saperas, Daniel Rodríguez-Alcalde, Ariadna Sanchez Garcia, Lorena Moreno, Joan Brunet, Miquel Serra, Elena Aguirre, Marta Ponce, Teresa Ocaña, Marta Carrillo-Palau, Antoni Castells, Andres Dacal, Laura Rivas, Catalina Garau, Virginia Piñol, Berta Caballol, Liseth Rivero, M. J. López-Arias, Teresa Ramón y Cajal, Eva Martínez de Castro, Carmen Poves, Lorena Rodríguez-Alonso, Inmaculada Salces, Francisco Rodríguez-Moranta, Cristina de la Peña Álvarez, Lucía Cid, Maite Herraiz, Gemma Llort, Francesc Balaguer, Evelien Dekker, Gabriel Capellá, Victorine H. Roos, Adrià Lopez Fernandez, Luis Bujanda, María Dolores Picó, Marta Garzon, Leticia Moreira, Matilde Navarro, Xavier Bessa, Maria Pellise, Rodrigo Jover, J. Balmaña, Angeles Pizarro, Sabela Carballal, Joaquín Cubiella, and Marta Pineda
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medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,business.industry ,Colorectal cancer ,media_common.quotation_subject ,General surgery ,Gastroenterology ,Colonoscopy ,medicine.disease ,Lynch syndrome ,Medicine ,Quality (business) ,business ,media_common - Published
- 2020
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4. Mo1978 - Comprehensive Analysis of Methylation Field Defect in Colorectal Carcinogenesis
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Juan José Lozano, Antoni Castells, Ariadna Sánchez, Maria Vila-Casadesús, Sabela Carballal, Jordi Camps, Adela Castillejo, Mar Giner-Calabuig, Gerhard Jung, Miriam Cuatrecasas, Francesc Balaguer, Miren Alustiza, Cristina Alenda, Rodrigo Jover, José Luis Soto, Miriam Juárez, Eva Hernández-Illán, Lorena Moreno, Maria Pellise, Liseth Rivero, Isabel Quintanilla, and Jenifer Muñoz
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Hepatology ,Field (physics) ,Gastroenterology ,Cancer research ,Methylation ,Colorectal carcinogenesis ,Biology - Published
- 2018
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5. 1067 - Analysis of Methylation Field Defect in Serrated Polyposis Syndrome
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Juan José Lozano, Miriam Cuatrecasas, Lorena Moreno, Eva Hernández-Illán, Sabela Carballal, Francesc Balaguer, Mireia Diaz, Gerhard Jung, Liseth Rivero, Jenifer Muñoz, Maria Pellise, Teresa Ocaña, Ariadna Sánchez, and Antoni Castells
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Nuclear magnetic resonance ,Materials science ,Hepatology ,Field (physics) ,Gastroenterology ,Methylation ,Serrated polyposis - Published
- 2018
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6. Mo1736 - Identification of Clinical, Genetic and Endoscopic Predictors of Incident Colorectal Cancer in Lynch Syndrome
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Elena Aguirre, Daniel Rodríguez-Alcalde, Xavier Bessa, Liseth Rivero, Lorena Rodríguez-Alonso, Gemma Llort, Carme Yagüe, Virginia Piñol, Marta Carrillo-Palau, Adolfo Suárez, Matilde Navarro, Maria Pellise, Ariadna Sánchez, Lorena Moreno, Andres Dacal, Leticia Moreira, Eva Martínez de Castro, Marta Ponce, Esteban Saperas, Angeles Pizarro, Carmen Poves, Inmaculada Salces, Teresa Ocaña, Laura Rivas, Catalina Garau, Sabela Carballal, Adrià Lopez Fernandez, Marta Garzon, Joan Brunet, Maite Herraiz, Teresa Ramón y Cajal, Cristina de la Peña Álvarez, Alexandra Gisbert-Beamud, Francesc Balaguer, Luis Bujanda, Antoni Castells, Lucía Cid, J. Balmaña, María Dolores Picó, Rodrigo Jover, Miquel Serra-Burriel, Gabriel Capellá, Francisco Rodríguez-Moranta, Joaquín Cubiella, and Marta Pineda
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Oncology ,medicine.medical_specialty ,Hepatology ,Colorectal cancer ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Clinical genetic ,Identification (biology) ,medicine.disease ,business ,Lynch syndrome - Published
- 2018
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7. 1065 Incidence of Colonic Neoplasia in Patients With Serrated Polyposis Syndrome Who Undergo Endoscopic Surveillance: A Multicenter Study
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Daniel Rodríguez-Alcalde, Mariano González, Sabela Carballal, Carmen Poves, Virginia Piñol, Rodrigo Jover, Maria Pellise, Joaquín Cubiella, Antoni Castells, Jorge López-Vicente, Francesc Balaguer, Leticia Moreira, Luis Bujanda, Francisco Rodríguez-Moranta, Inés Castro, Liseth Rivero Sanchez, Victoria Gonzalo, Enrique Quintero, Lorena Rodríguez, Susana Oquiñena, Joan Clofent, María López-Cerón, Xavier Bessa, Francisco J. Martín Fernández, Eloisa Moya, Luis Hernández, Esteve Saperas, Pilar Esteban, Lucía Cid, Miriam Cuatrecasas, and Maria Liz Leoz
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medicine.medical_specialty ,Hepatology ,Multicenter study ,business.industry ,Internal medicine ,Incidence (epidemiology) ,Gastroenterology ,medicine ,In patient ,business ,Serrated polyposis - Published
- 2016
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8. Su1943 Colorectal Cancer Risk Factors in Patients With Serrated Polyposis Syndrome: Results From a Multicenter Nation-Wide Study
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Francisco J. Martín Fernández, Victoria Gonzalo, Joaquín Cubiella, Francisco Rodríguez-Moranta, Montserrat Andreu, Mariano Gonzalez-Haba Ruiz, Anna Baiges, Xavier Bessa, Maria Liz Leoz, Teresa Ocaña, Inés Castro, Susana Oquiñena, Sabela Carballal, Luis Hernández, Enrique Quintero, Virginia Piñol, María López-Cerón, Antoni Castells, Juan Clofent, Daniel Rodriguez Alcalde, Pilar Esteban, Maria Pellise, Leticia Moreira, Jorge Lopez, Vicent Hernandez, Maria Varela, Juan Diego Morillas, Miriam Cuatrecasas, Rodrigo Jover, Francesc Balaguer, Luis Bujanda, Lorena Rodriguez Alonso, Angel Barturen, Eloisa Moya, and Liseth Rivero-Sánchez
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Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Colorectal cancer ,Internal medicine ,Gastroenterology ,medicine ,In patient ,business ,medicine.disease ,Serrated polyposis - Published
- 2015
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9. 671 Risk of Advanced Neoplasm in Individuals With Family History of Colorectal Cancer
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Anna Baiges, Teresa Ocaña, Maria Liz Leoz, Leticia Moreira, Antoni Castells, María López-Cerón, Francesc Balaguer, Maria Pellise, Sabela Carballal, and Raquel Rodriguez
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Oncology ,medicine.medical_specialty ,Hepatology ,Colorectal cancer ,business.industry ,Internal medicine ,Gastroenterology ,medicine ,Neoplasm ,Family history ,medicine.disease ,business - Published
- 2014
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10. 107 Somatic MLH1 Promoter Hypermethylation Is a Frequent Event in Lynch Syndrome Colorectal Cancers
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Teresa Ocaña, C. Richard Boland, Antoni Castells, Francesc Balaguer, Sabela Carballal, Angel Carracedo, Rodrigo Jover, Montserrat Andreu, Maria Liz Leoz, Miriam Cuatrecasas, Ajay Goel, Mildred Arnold, Patricia Fernandez, Jenifer Muñoz, Xavier Llor, Isabel Quintanilla, Maria Pellise, and Leticia Moreira
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Hepatology ,Promoter hypermethylation ,business.industry ,Somatic cell ,Event (relativity) ,Gastroenterology ,medicine ,Cancer research ,MLH1 ,medicine.disease ,business ,Lynch syndrome - Published
- 2013
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11. Su1084 Clinicopathological Characterization of Serrated Polyposis Syndrome
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María López-Cerón, Teresa Ocaña, Maria Liz Leoz, Daniel Rodríguez-Alcalde, Antoni Castells, Miriam Cuatrecasas, Sabela Carballal, Francesc Balaguer, Maria Pellise, Patricia Fernandez, and Leticia Moreira
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medicine.medical_specialty ,Hepatology ,medicine.diagnostic_test ,Adenoma ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,Incidence (epidemiology) ,Gastroenterology ,Colonoscopy ,medicine.disease ,Serrated polyposis ,Polypectomy ,Internal medicine ,Relative risk ,medicine ,Risk assessment ,business - Abstract
Background. Post polypectomy surveillance colonoscopies are a huge burden on healthcare systems. Improved risk assessment could result in reduced colonoscopy use. Our aim was to identify patient, polyp and program factors associated with incidence of new neoplasia at first surveillance colonoscopy following an initial diagnosis of colorectal adenomaMethods. We reviewed colorectal cancer (CRC) surveillance outcome data contained in a colonoscopy recall database. Findings at first surveillance colonoscopy in people who had been diagnosed with advanced (high risk, HRA) adenoma ( ≥ 3 polyps, size ≥10mm, villous component, serration, high grade dysplasia) at diagnostic colonoscopy were compared to those with non-advanced (low risk, LRA) adenomas at diagnosis. Data included patient age and sex, polyp features and location, and interval between colonoscopies. Outcomes were compared using bivariate (Fisher's exact) and multivariate (multinomial logistic regression) analyses. Results. Among 457 eligible patients, 266 (58%) were males, and mean age at diagnostic colonoscopy was 63 years. Mean time between diagnostic and surveillance colonoscopy were 43 and 31 months (median 40 and 35 months) for HRA and LRA respectively. There was a significant difference between groups for outcome at surveillance (Table, p=0.014). At the multivariate level, significant associations between outcome at surveillance and polyp features at diagnosis were limited. Controlling for age, gender and colonoscopy interval, those with LRA at diagnosis were more likely to have LRA at surveillance (RRR=1.91, p= 0.023, 95% CI 1.09-3.34). There was a non-significant trend towards increased risk for advanced neoplasia (HRA plus cancers) at surveillance in those originally diagnosed with HRA (RRR=1.31). Age and sex were significant predictors of adenoma incidence at surveillance. Relative risk ratios for HRA increased with each year of age for both males (RRR 1.04, p=0.007, 95% CI 1.01-1.07) and females (RRR 1.04, p=0.019, 95% CI 1.01-1.07), while the relative risk ratio for LRA increased significantly per year of age for males only (RRR 1.03, p=0.007, 95% CI 1.01-1.06). Conclusions: While features of polyps at diagnostic colonoscopies remain key predictors of findings at surveillance, age and sex are additional variables that predict worse outcome. Reduced risk of LRA at surveillance in patients previously diagnosed with HRA may reflect a more conscientious approach by proceduralists at diagnosis. Post polypectomy surveillance could focus more towards older patients. Table. Surveillance outcomes following a diagnosis of low or high risk adenoma.
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- 2013
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