1. The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder
- Author
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Joanna Szopinska-Tokov, Sarita A. Dam, Alejandro Arias-Vasquez, Mirjam Bloemendaal, Maria Amato, and Jeanette C. Mostert
- Subjects
0301 basic medicine ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,business.industry ,Gut–brain axis ,Gastroenterology ,Treatment options ,Brain ,Vagus Nerve ,medicine.disease ,behavioral disciplines and activities ,Diet ,Gastrointestinal Microbiome ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Attention Deficit Disorder with Hyperactivity ,mental disorders ,Disease biomarker ,Medicine ,Attention deficit hyperactivity disorder ,Humans ,030211 gastroenterology & hepatology ,business ,Neuroscience - Abstract
Genetic and environmental factors play a role in the cause and development of attention-deficit/hyperactivity disorder (ADHD). Recent studies have suggested an important role of the gut-brain axis (GBA) and intestinal microbiota in modulating the risk of ADHD. Here, the authors provide a brief overview of the clinical and biological picture of ADHD and how the GBA could be involved in its cause. They discuss key biological mechanisms involved in the GBA and how these may increase the risk of developing ADHD. Understanding these mechanisms may help to characterize novel treatment options via identification of disease biomarkers.
- Published
- 2019