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Competing Interests: Dr Rubin has received grantsupport from Takeda, and he has served as a consultant for AbbVie, AltruBio, Arena Pharmaceuticals, Bristol Myers Squibb, Genentech/Roche, Gilead Sciences, Iterative Scopes, Janssen Pharmaceuticals, Lilly, Pfizer, Prometheus Biosciences, Takeda, and TechLab Inc.

Competing Interests: Dr Charlton has served as a consultant for Novartis, Pfizer, Gilead, Intercept Pharmaceuticals, Metacrine, Siemens, NGM Bio, ProSciento, Celgene/Bristol Myers Squibb, Fractyl, HistoIndex, and Terns Pharmaceuticals. He has received research support from Novartis, Pfizer, Gilead, Intercept Pharmaceuticals, and Celgene/Bristol Myers Squibb

Competing Interests: Dr Rubin is a consultant for and has received grant support from AbbVie, Janssen, Pfizer, and Takeda.

Competing Interests: Dr Cohen has served on the speakers bureau (for disease state only, not promotional drug talks) for AbbVie, Pfizer, and Takeda. He has also served as a consultant and/or on the advisory and/or scientific advisory board for AbbVie Laboratories, Celgene, Eli Lilly, Hospira, Janssen, Pfizer, Sandoz Biopharmaceuticals, Takeda, and UCB Pharma.