1. Mangafodipir-enhanced magnetic resonance cholangiography for the diagnosis of bile duct leaks
- Author
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Y Billaud, Pascal Fouque, Guillaume Gautier, Frank Pilleul, Pierre-Jean Valette, Olivier Monneuse, and Arielle Crombé-Ternamian
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Contrast Media ,Percutaneous transhepatic cholangiography ,Cholangiography ,Postoperative Complications ,medicine ,Mangafodipir ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Edetic Acid ,Aged ,Manganese ,medicine.diagnostic_test ,Bile duct ,business.industry ,Gallbladder ,Gastroenterology ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Liver ,Biliary tract ,Pyridoxal Phosphate ,Cholecystectomy ,Female ,Radiology ,Bile Ducts ,business ,medicine.drug - Abstract
Background The purpose of this prospective study was to assess the value of contrast-enhanced magnetic resonance cholangiography with mangafodipir trisodium perfusion for detection and localization of trauma-induced and postoperative bile duct leaks. Methods Eleven patients with suspected bile duct leaks after trauma (n=5) or surgery (n=6) were included. Patients with suspected leaks after cholecystectomy were excluded. All patients underwent contrast-enhanced magnetic resonance cholangiography with two-dimensional axial and three-dimensional coronal gradient-echo images acquired 1 to 3 hours after intravenous administration of mangafodipir trisodium perfusion. Contrast-enhanced magnetic resonance cholangiography findings were correlated with direct cholangiography obtained in all patients, including endoscopic retrograde (n=7) and percutaneous transhepatic cholangiography (n=4). Results Biliary tract enhancement was identified in all patients on contrast-enhanced magnetic resonance cholangiography. Peritoneal cavity fluid and bile collections that contained extravasated mangafodipir trisodium (increased signal intensity on gradient-echo sequences) were demonstrated in 6 patients. Direct cholangiography confirmed the presence of bile duct leaks in these 6 patients and the absence of bile duct leaks in 5 patients. There was no false-negative or false-positive contrast-enhanced magnetic resonance cholangiography. Conclusions Mangafodipir-enhanced magnetic resonance cholangiography is a noninvasive technique that can provide functional biliary information with excellent depiction of bile duct leaks.
- Published
- 2004