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7. 938 RHRK 941 is responsible for Ubiquitin specific protease 48 nuclear translocation which can stabilize NF-κB (p65) in the nucleus.

Author

Liu YL, Yan J, Zheng J, and Tian QB

Subjects
Active Transport, Cell Nucleus, Animals, COS Cells, Chlorocebus aethiops, HEK293 Cells, Humans, Protein Sorting Signals, Ubiquitin-Specific Proteases chemistry, Cell Nucleus metabolism, Transcription Factor RelA metabolism, Ubiquitin-Specific Proteases metabolism
Abstract

The transcription factor NF-κB is a key regulator of cellular processes. A mechanism that contributes to timely termination of NF-κB activity is UPS-dependent degradation of p65 in the nucleus or on chromatin. The ubiquitin-specific protease that takes part in this process and its molecular mechanisms are shown in previous study, but which structural feature of USP48 was responsible for these effects is unknown. Here, we show that maybe the stability of NF-κB is controlled by proteasome-mediated degradation and ubiquitin-specific protease 48 (USP48), also known as synaptic ubiquitin-specific protease (synUSP) or USP31, can enhance NF-κB stability through proteasome-dependent regulation in the nucleus. USP48 contains a carboxyl-terminal nuclear localizing signal, 938 RHRK 941 , which is responsible for its nuclear translocation. Our results demonstrate a more detailed mechanism for this member of the USP gene family in cellular processes., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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