1. Hirunorms, novel hirudin-like direct thrombin inhibitors
- Author
-
Mario Cappiello, Antonella Del Corso, Pier Giuseppe Vilardo, and Umberto Mura
- Subjects
Pharmacology ,biology ,medicine.drug_class ,Chemistry ,Anticoagulant ,Antithrombin ,Hirudin ,Thrombin ,Thrombosis ,Hirudins ,Antithrombins ,Biochemistry ,In vivo ,Enzyme inhibitor ,Antithrombotic ,medicine ,biology.protein ,Humans ,Peptides ,medicine.drug ,Discovery and development of direct thrombin inhibitors - Abstract
1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis.
- Published
- 1998