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Your search keyword '"Wang, Eric"' showing total 5 results
Start Over Author "Wang, Eric" Journal genes & development
5 results on '"Wang, Eric"'

1. Cell-type-specific dysregulation of RNA alternative splicing in short tandem repeat mouse knockin models of myotonic dystrophy

Author

Nutter, Curtis A., primary, Bubenik, Jodi L., additional, Oliveira, Ruan, additional, Ivankovic, Franjo, additional, Sznajder, Łukasz J., additional, Kidd, Benjamin M., additional, Pinto, Belinda S., additional, Otero, Brittney A., additional, Carter, Helmut A., additional, Vitriol, Eric A., additional, Wang, Eric T., additional, and Swanson, Maurice S., additional

Published
2019
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3. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

Author

Shi, Junwei, primary, Whyte, Warren A., additional, Zepeda-Mendoza, Cinthya J., additional, Milazzo, Joseph P., additional, Shen, Chen, additional, Roe, Jae-Seok, additional, Minder, Jessica L., additional, Mercan, Fatih, additional, Wang, Eric, additional, Eckersley-Maslin, Melanie A., additional, Campbell, Amy E., additional, Kawaoka, Shinpei, additional, Shareef, Sarah, additional, Zhu, Zhu, additional, Kendall, Jude, additional, Muhar, Matthias, additional, Haslinger, Christian, additional, Yu, Ming, additional, Roeder, Robert G., additional, Wigler, Michael H., additional, Blobel, Gerd A., additional, Zuber, Johannes, additional, Spector, David L., additional, Young, Richard A., additional, and Vakoc, Christopher R., additional

Published
2013
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4. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

Author

Zuber, Johannes, primary, Rappaport, Amy R., additional, Luo, Weijun, additional, Wang, Eric, additional, Chen, Chong, additional, Vaseva, Angelina V., additional, Shi, Junwei, additional, Weissmueller, Susann, additional, Fellman, Christof, additional, Taylor, Meredith J., additional, Weissenboeck, Martina, additional, Graeber, Thomas G., additional, Kogan, Scott C., additional, Vakoc, Christopher R., additional, and Lowe, Scott W., additional

Published
2011
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5. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Author

Junwei Shi, Whyte, Warren A., Zepeda-Mendoza, Cinthya J., Milazzo, Joseph P., Chen Shen, Jae-Seok Roe, Minder, Jessica L., Mercan, Fatih, Wang, Eric, Eckersley-Maslin, Melanie A., Campbell, Amy E., Kawaoka, Shinpei, Shareef, Sarah, Zhu Zhu, Kendall, Jude, Muhar, Matthias, Haslinger, Christian, Ming Yu, Roeder, Robert G., and Wigler, Michael H.

Subjects
*CHROMATIN, *CANCER cells, *ACUTE leukemia, *GENE expression, *ADENOSINE triphosphatase, *LEUKEMIA
Abstract

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cell types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. To account for this context-specific function, we identify a cluster of lineage-specific enhancers located 1.7 Mb downstream from Myc that are occupied by SWI/SNF as well as the BET protein Brd4. Brg1 is required at these distal elements to maintain transcription factor occupancy and for long-range chromatin looping interactions with the Myc promoter. Notably, these distal Myc enhancers coincide with a region that is focally amplified in ∼3% of acute myeloid leukemias. Together, these findings define a leukemia maintenance function for SWI/SNF that is linked to enhancer-mediated gene regulation, providing general insights into how cancer cells exploit transcriptional coactivators to maintain oncogenic gene expression programs. [ABSTRACT FROM AUTHOR]

Published
2013
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