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1. [Genetic determinants of resistance of hospital-associated strains of Klebsiella pneumoniae to β-lactam antibiotics isolated in neonates].

Author

Dubodelov DV, Lubasovskaya LA, Shubina ES, Mukosey IS, Korostin DO, Kochetkova TO, Bogacheva NA, Bistritskiy AA, Gordeev AB, Trofimov DY, Priputnevich TV, and Zubkov VV

Subjects
Female, Humans, Iatrogenic Disease, Infant, Newborn, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae isolation & purification, Male, Bacterial Proteins genetics, Cephalosporin Resistance, Klebsiella pneumoniae genetics, beta-Lactamases genetics
Abstract

According to the results of analysis of whole genome sequencing, the presence of genes having resistance to β-lactam antibiotics in hospital-associated strains of Klebsiella pneumoniae was studied. The strains were isolated from neonatal intensive care units. The data obtained were compared with the results of antimicrobial susceptibility testing of isolated microorganisms. Among other strains resistant to cephalosporins, the dominance of genes of CTX-M-type extended-spectrum β-lactamases was shown. It was revealed that one of eight strains phenotypically resistant and moderately resistant to carbapenems have the blaOXA-48 carbapenemase gene.

Published
2016

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