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A recent study conducted by researchers at the University of Tehran in Iran identified three species of Enterobacteriaceae as the causative agents of date palm offshoot decline and bud rot in Khuzestan province. The study collected samples from diseased offshoots in palm groves and isolated pathogenic strains, including Klebsiella oxytoca, Kosakonia radicincitans, and Citrobacter koseri. The research suggests that the outbreak of decline and rot disease may have been intensified by flooding in the region during 2019 and 2020. This study provides new insights into the impact of Gram-Negative Bacteria on date palm health and agriculture. [Extracted from the article]

Researchers at the Department of Medical Laboratories in Baghdad, Iraq, have reported on new findings regarding Klebsiella oxytoca, a multidrug-resistant pathogen found in hospitals. The study focused on detecting antibiotic-resistant profiles and virulence genes in clinical isolates, highlighting the threat these strains pose to human health. The research emphasizes the importance of rapid identification of hypervirulent and antibiotic-resistant strains in local hospitals to combat hospital-acquired infections effectively. [Extracted from the article]

A recent study conducted at Osun State University focused on the characterization of rhodanese, a cyanide detoxifying enzyme, synthesized by wild and mutated strains of Klebsiella oxytoca JCM 1665. The research found that the mutant strains exhibited higher extracellular rhodanese yield compared to the wild strain. The study highlighted the potential of enhancing Klebsiella oxytoca JCM 1665 to overexpress rhodanese, which could improve the efficiency of cyanide bioremediation processes. [Extracted from the article]

A recent study conducted at Kazan Federal University in Russia focused on Klebsiella oxytoca, a Gram-Negative Bacteria known to cause various infections. The research found that inactivation of type 3 fimbriae increased the adhesion of K. oxytoca to lung epithelial cells, suggesting a complex adhesive apparatus for the bacteria. The study highlights the importance of understanding the virulence factors of Klebsiella species in order to develop effective treatment strategies. [Extracted from the article]

Researchers at Shandong University recently published a study on metabolic engineering, focusing on the production of a-ketoisovalerate using whey powder as a carbon source. The study involved inactivating specific enzymes in Klebsiella oxytoca VKO-9 to enhance a-ketoisovalerate accumulation and overexpressing key genes to improve production. The findings suggest that this engineered strain, K. oxytoca KIV-7, can efficiently produce a-ketoisovalerate from whey powder, offering potential for stable fermentation and derivative production. The study was published in Microbial Cell Factories and funded by various organizations in China. [Extracted from the article]

A recent study conducted at Nanjing Forestry University in China explored the use of microscale zero-valent iron (mZVI) to enhance denitrification in Klebsiella oxytoca bacteria. The research found that mZVI significantly improved the elimination of nitrite (NO2--N) during denitrification processes, showcasing its facilitative role in the reduction of nitrogen compounds. The study concluded that mZVI plays a pivotal role in enhancing denitrification efficiency through various mechanisms, as supported by genetic abundance and enzyme activity analyses. [Extracted from the article]

A recent report from the Minnesota Department of Health discusses a study on Klebsiella oxytoca, a type of bacteria. The study focused on a containment response to a KPC-CRE outbreak in a long-term care facility. The researchers conducted screening and sequencing to identify the genetic relationships among the isolates. They found that the bacteria were present in the premise plumbing of the facility, and gaps in infection prevention and control measures were observed. The study concludes that strict implementation of infection prevention measures, including addressing the spread of bacteria from the plumbing, is necessary to stop transmission within the facility. [Extracted from the article]

This article discusses the discovery of a plasmid stabilization system called the hipBA operon in the bacterium Klebsiella michiganensis. The hipBA operon is responsible for plasmid stability and antibiotic persistence. The researchers characterized the hipBA locus and found that it is encoded on a plasmid carried by K. michiganensis. They also compared the hipBA modules across the Klebsiella oxytoca species complex. This research expands our understanding of the role of the hipBA system in plasmid stability and its implications for enteric pathogen evolution and multidrug resistance. [Extracted from the article]

A recent report from Pusan National University in South Korea discusses research on Klebsiella oxytoca, a Gram-negative bacteria that can produce 1,3-propanediol (PDO) through the fermentation of glycerol. The study explores how the addition of formate to glycerol fermentation can enhance PDO production without genetic modification. The researchers found that the addition of formate increased glycerol consumption and PDO production simultaneously. This research provides an alternative bioconversion strategy for PDO production. [Extracted from the article]

A recent study conducted by researchers at Chi Mei Medical Center in Taiwan examined the effectiveness of ceftolozane/tazobactam (TOL/TAZ) against various bacterial strains. The study found that TOL/TAZ demonstrated strong activity against Pseudomonas aeruginosa and carbapenem-susceptible Enterobacterales in Taiwan. However, its efficacy varied among different species, particularly those associated with chromosomally-mediated AmpC production. The research provides valuable insights into the in-vitro performance of TOL/TAZ and its potential applications in treating bacterial infections. [Extracted from the article]

A recent study conducted by researchers at the University of Tokyo explores the production of glutamate, an essential biological compound, using the nitrogen-fixing bacterium Klebsiella oxytoca. The traditional production process for glutamate requires a large amount of ammonium, which is generated through an energy-consuming and CO2-emitting process. The researchers developed a strategy that utilizes aerial nitrogen and a simultaneous supply of glucose and citrate as carbon sources to enhance the nitrogenase activity of K. oxytoca. This approach offers a sustainable and eco-friendly method for producing nitrogen-containing compounds. [Extracted from the article]

A patent has been issued to the Massachusetts Institute of Technology (MIT) for the directed evolution of a synthetic gene cluster. The patent describes methods and products for refactoring complex genetic clusters, including the removal of non-coding DNA and non-essential genes, as well as the use of synthetic regulatory elements and randomized codons. The invention aims to overcome challenges in the engineering of large genetic systems by improving design efficiency and reducing costs. The patent provides detailed methods for scarless stitching and the production of plasmids with refactored gene clusters. [Extracted from the article]

This article discusses the role of the transcriptional regulator Lrp in activating the expression of genes involved in the biosynthesis of the tilivalline enterotoxin in Klebsiella oxytoca. The tilivalline enterotoxin is a non-ribosomal peptide that causes antibiotic-associated hemorrhagic colitis. The study found that Lrp directly activates the transcription of the genes responsible for tilivalline biosynthesis by binding to the intergenic regulatory region in a leucine-dependent manner. The lack of Lrp resulted in reduced cytotoxicity of K. oxytoca on HeLa cells due to decreased tilivalline production. This research provides new insights into how cytotoxin-producing K. oxytoca strains control the expression of genes involved in their virulence. [Extracted from the article]

A new study conducted by researchers at the Ministry of Agriculture and Rural Affairs of China has investigated the environmental compatibility and genome flexibility of Klebsiella oxytoca, an emerging pathogen that can cause infectious diseases in humans. The study found that K. oxytoca isolates from eight species of aquatic animals were able to grow under a wide range of environmental conditions and exhibited various adaptation traits. The genome sequences of the isolates revealed the presence of numerous mobile genetic elements, suggesting horizontal gene transfer and significant genome variation in K. oxytoca evolution. This study provides valuable insights into the characteristics of K. oxytoca from aquatic animal origins. [Extracted from the article]

Keywords: Asia; China; Enterobacteriaceae; Epidemiology; Gammaproteobacteria; Genetics; Gram-Negative Bacteria; Gram-Negative Facultatively Anaerobic Rods; Klebsiella; Klebsiella oxytoca; Proteobacteria EN Asia China Enterobacteriaceae Epidemiology Gammaproteobacteria Genetics Gram-Negative Bacteria Gram-Negative Facultatively Anaerobic Rods Klebsiella Klebsiella oxytoca Proteobacteria 1557 1557 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Klebsiella oxytoca. Different from the clonal dissemination of high-risk carbapenem-resistant K. pneumoniae strains, our research revealed a polyclonal dissemination characteristic of CR K. oxytoca complex in China. [Extracted from the article]

Keywords for this news article include: Berlin, Germany, Europe, Genomics and Genetics, Technical University Berlin (TU Berlin). Keywords: Berlin; Germany; Europe; Genomics and Genetics EN Berlin Germany Europe Genomics and Genetics 598 598 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Genomics and Genetics. [Extracted from the article]

Keywords: Nottingham; United Kingdom; Europe; Bacteriophages; Enterobacteriaceae; Gammaproteobacteria; Gram-Negative Bacteria; Gram-Negative Facultatively Anaerobic Rods; Klebsiella; Klebsiella oxytoca; Proteobacteria; Viruses EN Nottingham United Kingdom Europe Bacteriophages Enterobacteriaceae Gammaproteobacteria Gram-Negative Bacteria Gram-Negative Facultatively Anaerobic Rods Klebsiella Klebsiella oxytoca Proteobacteria Viruses 1309 1309 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Gram-Negative Bacteria - Klebsiella oxytoca have been presented. Researchers from Nottingham Trent University Report Recent Findings in Klebsiella oxytoca (Lytic Bacteriophage Vb kmis-kmi2c Disrupts Biofilms Formed By Members of the Klebsiella Oxytoca Complex, and Represents a Novel Virus Family and Genus) Comparative phylogenetic and network-based analyses were used to characterize the genome of phage vB KmiS-Kmi2C (circular genome of 42 234 bp predicted to encode 55 genes), demonstrating it shared little similarity with other known phages.". [Extracted from the article]

The article discusses research which reported the phenotypic and genomic characterization of phage vB_KmiS-Kmi2C, its effect on members of the Klebsiella oxytoca complex pathogens and potential as a novel genus of lytic bacteriophage.