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Various lines of evidence, including the occurrence of bitumen and fluid inclusions, show that oil charge once took place in the Kela-2 gas field, Kuqa foreland basin, Northwest China. However, the scale of the ancient oil reservoir remains unclear, as does the process by which the reservoir evolved into the present dry gas field. Here, using data from analyses of fluid inclusions, petrography, laser Raman spectroscopy, and quantitative fluorescence, the hydrocarbon accumulation history of the Kela-2 gas field is reconstructed. The results show that the gas field underwent three periods of hydrocarbon charging and one period of adjustment. The first oil charging occurred at about 12 Ma, as recorded by the first group of oil inclusions containing 0–8 vol.% gas with yellowish-brown fluorescence. The second charging involved mature oil charging at about 4 Ma, recorded by the second group of oil inclusions containing 15–25 vol.% gas with blue-white fluorescence. According to quantitative grain fluorescence (QGF) and rock pyrolysis analysis, an ancient oil reservoir existed with an oil-column height of about 350 m, and the paleo oil–water contact was lower than the present gas–water contact. Under intense thrusting from 3 Ma, the ancient oil reservoir was destroyed, with oil escaping through the Kashangtuokai thrust fault, which broke the salt layer, as this layer at that time lay in the brittle deformation domain. The inferred destruction of the ancient oil reservoir is supported by the numerous oil and gas shows at the surface and in shallow layers near the Kashangtuokai fault, as well as the anomalous development of authigenic kaolinite in the gas reservoir, which was enhanced by an open or semiopen system caused by the fault breaking through the salt layer. Subsequently, with increasing burial depth to more than 3000 m, the fault that had cut through the salt layer annealed because the salt layer then lay within the ductile deformation domain. The higher overpressure that occurred during the third gas charging at about 2 Ma reflected the annealing of the fault in the salt layer, favoring late gas accumulation and preservation. The evolution of the Kela-2 gas field provides an important case study for understanding the role of the salt layer crossing the brittle–plastic transition and the dynamic evolution of the salt caprock in salt-containing foreland basins.