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The ongoing coronavirus disease 2019 (COVID‐19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID‐19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID‐19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID‐19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1–2 years. Moreover, based on the simulated results by the COVID‐19 data, it is found that the temperate and cold climate regions have higher infection rates than the tropical and arid climate regions, which indicates that climate may modulate the transmission of COVID‐19. The role of the climate on the COVID‐19 variations should be concluded with more data and more cautions. The non‐pharmaceutical interventions still play the key role in controlling and prevention this global pandemic. Plain Language Summary: In this work, global COVID‐19 data were used to examine the dynamical variations from the perspectives of immunity and contact over five climate regions: tropical, arid, temperate, cold, and polar. A new approach is proposed to obtain the infection rates based on the COVID‐19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID‐19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1–2 years. Moreover, it is found that the temperate and cold climate regions have higher infection rates than the tropical and arid climate regions, which indicates that climate may modulate the transmission of COVID‐19. Key Points: A new approached is proposed to predict the future COVID‐19 variations rather than relying on information on other corona virusesCOVID‐19 pandemic will persist in multiple periods of 1–2 yearsThe temperate and cold climate regions have higher infection rates than the tropical and arid climate regions [ABSTRACT FROM AUTHOR]