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Seismic vulnerability assessments play a significant role in comprehensive risk mitigation efforts and seismic emergency planning, especially for urban areas with a high population density and a complex construction environment. Traditional approaches such as in situ fieldwork are accurate for conducting seismic vulnerability assessments of buildings; however, they are too much time and cost-consuming, especially in moderate to low seismic hazard regions. To address this issue, an integrated approach for a macroseismic vulnerability assessment composed of data mining methods and GIScience technology was presented and applied to Urumqi, China. First, vulnerability proxies were established via in situ data of buildings in the Tianshan District with an EMS-98 vulnerability classification scheme and two data mining methods, namely, support vector machine and association rule learning methods. Then, vulnerability proxies were applied to the Urumqi database, and the accuracy was validated. Finally, seismic risk maps were constructed through data consisting of direct damage to buildings and human casualties. The results indicated that the two data mining methods could achieve desirable accuracies and stabilities when estimating the seismic vulnerability. The seismic risk of Urumqi was estimated as Slight with a predicted number of 61,380 homeless people for a seismic intensity scenario of VIII. [ABSTRACT FROM AUTHOR]