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This paper presents an approach to improve the previously proposed 2-D topography modeling (Ding et al., 2019) that is primarily based on inversion of low-temperature thermochronological data. The new approach requires thermochronological data from both horizontal transect and vertical profiles to yield a more comprehensive modeling of topographic evolution. This modeling allows for (1) reconstruction of paleotopography evolution and (2) calculation of spatial distribution of paleo-geothermal gradients over time; therefore, it is possible to deduce more reliable exhumation histories even for non-steady state topographic evolution. The deduced exhumation histories are used to re-evaluate the topography modeling results. This approach when applied to the Dabie orogen in Eastern China suggests an uneven topographic evolution along the Xishui-Lu'an section and comparable exhumation histories for the Meichuan, the Tianzhushan, the Mingtangshan and the Tiantangzhai vertical profiles since the Late Cretaceous. The modeling results suggest that the location of the highest elevation in the NE-SW transect has been almost identical for the last 80 Ma although the elevation of the peak has reduced by ~3.3 km over the same period. The elevation reduction in the NE segment during 70–40 Ma is caused by extensional activity of the Xiaotian-Mozitan fault. The elevation reduction in the SW segment during 50–30 Ma is probably related to climate change, where the Paleogene topography change in the Dabie orogen played an important role introducing humid and warm air from the Pacific Ocean. • The Dabie orogen forms a tectonic and climatic boundary in Eastern China. • Thermochronological data collected along horizontal transects and vertical profiles • Transect/profile thermochronology results used for topography modeling • Rapid exhumation from 70 to 40 Ma along NE 2-D transect segment linked to faulting • Rapid exhumation from 50 to 30 Ma along SE 2-D transect segment linked to climate change [ABSTRACT FROM AUTHOR]