The Lefkada–Preveza coastal zone, NW Greece, is characterised by an active barrier system and related extensive beachrock sequences. Besides the gradual coastal processes of longshore drift and spit evolution, the presence of active tectonics and the occurrence of tsunamis have been documented in previous studies and are part of the coastal geomorphological system. In this paper, we present the results of detailed multi-proxy sedimentological and geomorphological investigations carried out along the northern part of the barrier system and in back-beach positions. Our findings suggest that extreme wave events contributed to coastal and environmental changes and involved temporary breakdown of the barrier system. Sedimentary findings suggest that one generation of event deposits may be related to the 365 AD Crete earthquake and associated tsunami. According to our results, the Lefkada coastal system formed by the interaction of both long-term, gradual and sudden, impulsive littoral geomorphodynamics. Extreme wave events are assumed to have played a significant role in the evolution of the present coastline, acting as recurrent impulsive disturbances of the coastal system. Subsequently, the onset of long-term gradual coastal processes, such as longshore drift, re-established a state of natural coastal balance by re-arranging the coastal sediments.