1. [Ocular changes after hormone replacement therapy in postmenopausal women. A preliminary report].
- Author
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Carranza Lira S, Jiménez AM, and Olhovich I
- Subjects
- Chlormadinone Acetate administration & dosage, Chlormadinone Acetate therapeutic use, Estrogens, Conjugated (USP) administration & dosage, Estrogens, Conjugated (USP) therapeutic use, Female, Humans, Hysterectomy, Middle Aged, Ovariectomy, Secretory Rate drug effects, Chlormadinone Acetate pharmacology, Estrogens, Conjugated (USP) pharmacology, Hormone Replacement Therapy, Intraocular Pressure drug effects, Postmenopause, Tears metabolism
- Abstract
Background: Ocular function is modified with hormone therapy; however, reports in literature are highly controversial., Objective: To analyze how hormone therapy modifies intraocular pressure and the number of tears shed by Mexican women., Patients and Methods: Eighteen postmenopausal women were studied and randomly divided into two groups, according to the treatment they received: group 1, conjugated equine estrogens (CEE) 0.625 mg/day (n=9) (hysterectomized women with bilateral oophorectomy) and group 2, CEE 0.625 mg/day plus chlormadinone 1 mg/day (n=9) (women with intact uterus). Changes in intraocular pressure and Schirmer's test were analyzed at baseline and three months after the treatment. Statistical analysis was performed with Student's t test for independent and paired samples., Results: There were no significant differences in intraocular pressure or Schirmer's test among groups, neither when comparing baseline and final results in each group independently., Conclusion: We could not demonstrate the effect of hormone replacement therapy on intraocular pressure and on Schirmer's test after three months of its administration.
- Published
- 2005