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INTRODUCTION: With the increased knowledge about the physiology of liposuction, procedures that involve larger body surface area are now being performed, which means an increased risk of hemorrhage and the need for transfusion. Homologous blood transfusion poses well-known risks, prompting the use of alternative and safer techniques such as autologous donation. To demonstrate the utility of autologousOBJECTIVE: transfusion in a cohort of patients undergoing large volume liposuction. Observational, retrospective andMETHODS: longitudinal cohort study in patients undergoing liposuction, in the period 2017-2021. Autologous donation was performed one month and two weeks prior to surgery, ensuring that all patients were prescribed medication and prophylactic dietary measures to avoid hemoglobin depletion. 40 les of women between 26 and 46 years of age, with a bodyRESULTS AND CONCLUSIONS: mass index between 24 and 30 m/kg2 and a median aspirated volume of 6.3 Lt were analyzed. Quantied bleeding averaged 675 cc. Both initial hemoglobin and hematocrit had statistically signicant differences with values in the postoperative period (pn all. However, vital signs remained stable and no transfusion-associated adverse events occurred. Autologous transfusion is an excellent strategy for the management of bleeding in large volume liposuction.