1. Sugar amino acids in designing new molecules.
- Author
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Chakraborty TK, Srinivasu P, Tapadar S, and Mohan BK
- Subjects
- Amino Acids chemical synthesis, Carbohydrate Sequence, Combinatorial Chemistry Techniques, Enkephalin, Leucine chemical synthesis, Enkephalin, Leucine chemistry, Furans chemistry, Models, Molecular, Molecular Conformation, Molecular Mimicry, Peptides, Cyclic chemical synthesis, Peptides, Cyclic chemistry, Peptoids chemistry, Pyrroles chemical synthesis, Pyrroles chemistry, Sugar Acids chemical synthesis, Amino Acids chemistry, Drug Design, Furans chemical synthesis, Sugar Acids chemistry
- Abstract
Emulating the basic principles followed by nature to build its vast repertoire of biomolecules, organic chemists are developing many novel multifunctional building blocks and using them to create 'nature-like' and yet unnatural organic molecules. Sugar amino acids constitute an important class of such polyfunctional scaffolds where the carboxyl, amino and hydroxyl termini provide an excellent opportunity to organic chemists to create structural diversities akin to Nature's molecular arsenal. This article describes some of our works on various sugar amino acids and many other related building blocks, like furan amino acids, pyrrole amino acids etc. used in wide-ranging peptidomimetic studies.
- Published
- 2005
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