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Role of CB1 receptor (encoded by CNR1 gene) in many physiological and pathophysiological functions has been reported. It has been studied that single nucleotide polymorphism (SNP) at position 1359 G/A (p. Thr453Th; rs1049353) of CNR1 gene alters normal function of CB1 receptor. Present study is a try to have a look on molecular epidemiological structure of1359 G/. A polymorphism in Pakistani population in ambition to cope the related diseases (schizophrenia, stress disorders, alcohol dependent diseases etc). Samples of DNA used in current research were extracted from blood of 194 healthy Pakistani subjects by using standard methods. We have used Google search engine for comparison of our results with other healthy subjects of related researches from world. The said populations are; English-Irish, Chinese, Japanese, European- American, German African-American, Italian and Turkish populations. Present study discovered significant variations in allele frequency distributions. We refer this difference to the change of the environment and geographical status. This is the first work on the polymorphism of CNR1 gene 1359 G/A allele frequency and its genotype in healthy Pakistani subjects in comparison to other healthy populations from the world as well as SAARC countries up to our knowledge. [ABSTRACT FROM AUTHOR]