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Optical coherence tomography angiography(OCTA), as a new non-invasive and non-contact blood flow imaging technique, is becoming more and more popular in clinic. This technique does not need intravenous injection of contrast agent, only by detecting the normal movement of red blood cells in capillaries, it can realize the detection of flowing blood and the morphological evaluation of tissue, and has the advantages of high speed, non-invasive, three-dimensional imaging and so on. At present, OCTA is used in the evaluation and diagnosis of many diseases in ophthalmology. This paper reviews the clinical application of OCTA in ophthalmology.