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27 results on '"Halfvarson, Jonas"'

2. Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis

Author

Leibovitzh, Haim, primary, Lee, Sun-Ho, additional, Raygoza Garay, Juan Antonio, additional, Espin-Garcia, Osvaldo, additional, Xue, Mingyue, additional, Neustaeter, Anna, additional, Goethel, Ashleigh, additional, Huynh, Hien Q, additional, Griffiths, Anne M, additional, Turner, Dan, additional, Madsen, Karen L, additional, Moayyedi, Paul, additional, Steinhart, A Hillary, additional, Silverberg, Mark S, additional, Deslandres, Colette, additional, Bitton, Alain, additional, Mack, David R, additional, Jacobson, Kevan, additional, Cino, Maria, additional, Aumais, Guy, additional, Bernstein, Charles N, additional, Panaccione, Remo, additional, Weiss, Batia, additional, Halfvarson, Jonas, additional, Xu, Wei, additional, Turpin, Williams, additional, and Croitoru, Kenneth, additional

Published
2023
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3. Development of an index to define overall disease severity in IBD

Author

Siegel, Corey A, Whitman, Cynthia B, Spiegel, Brennan M R, Feagan, Brian, Sands, Bruce, Loftus, Edward V, Jr, Panaccione, Remo, DʼHaens, Geert, Bernstein, Charles N, Gearry, Richard, Ng, Siew C, Mantzaris, Gerassimos J, Sartor, Balfour, Silverberg, Mark S, Riddell, Robert, Koutroubakis, Ioannis E, OʼMorain, Colm, Lakatos, Peter L, McGovern, Dermot P B, Halfvarson, Jonas, Reinisch, Walter, Rogler, Gerhard, Kruis, Wolfgang, Tysk, Curt, Schreiber, Stefan, Danese, Silvio, Sandborn, William, Griffiths, Anne, Moum, Bjorn, Gasche, Christoph, Pallone, Francesco, Travis, Simon, Panes, Julian, Colombel, Jean-Frederic, Hanauer, Stephen, and Peyrin-Biroulet, Laurent

Published
2018
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4. Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis

Author

Mellander, Marie-Rose, Bresso, Francesca, Munch, Andreas, Westerlind, Helga, Bonfiglio, Ferdinando, Assadi, Ghazaleh, Rafter, Joseph, Hübenthal, Matthias, Lieb, Wolfgang, Källberg, Henrik, Brynedal, Boel, Padyukov, Leonid, Halfvarson, Jonas, Törkvist, Leif, Bjork, Jan, Andreasson, Anna, Agreus, Lars, Almer, Sven, Miehlke, Stephan, Madisch, Ahmed, Ohlsson, Bodil, Löfberg, Robert, Hultcrantz, Rolf, Franke, Andre, and D’Amato, Mauro

Published
2017
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5. Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Author

Wouters, Mira M, Lambrechts, Diether, Knapp, Michael, Cleynen, Isabelle, Whorwell, Peter, Agréus, Lars, Dlugosz, Aldona, Schmidt, Peter Thelin, Halfvarson, Jonas, Simrén, Magnus, Ohlsson, Bodil, Karling, Pontus, Van Wanrooy, Sander, Mondelaers, Stéphanie, Vermeire, Severine, Lindberg, Greger, Spiller, Robin, Dukes, George, DʼAmato, Mauro, and Boeckxstaens, Guy

Published
2014
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6. Association of TNFSF15 polymorphism with irritable bowel syndrome

Author

Zucchelli, Marco, Camilleri, Michael, Nixon Andreasson, Anna, Bresso, Francesca, Dlugosz, Aldona, Halfvarson, Jonas, Törkvist, Leif, Schmidt, Peter T, Karling, Pontus, Ohlsson, Bodil, Duerr, Richard H, Simren, Magnus, Lindberg, Greger, Agreus, Lars, Carlson, Paula, Zinsmeister, Alan R, and DʼAmato, Mauro

Published
2011
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13. Natural disease course of Crohn’s disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study

Author

Burisch, Johan, primary, Kiudelis, Gediminas, additional, Kupcinskas, Limas, additional, Kievit, Hendrika Adriana Linda, additional, Andersen, Karina Winther, additional, Andersen, Vibeke, additional, Salupere, Riina, additional, Pedersen, Natalia, additional, Kjeldsen, Jens, additional, D’Incà, Renata, additional, Valpiani, Daniela, additional, Schwartz, Doron, additional, Odes, Selwyn, additional, Olsen, Jóngerð, additional, Nielsen, Kári Rubek, additional, Vegh, Zsuzsanna, additional, Lakatos, Peter Laszlo, additional, Toca, Alina, additional, Turcan, Svetlana, additional, Katsanos, Konstantinos H, additional, Christodoulou, Dimitrios K, additional, Fumery, Mathurin, additional, Gower-Rousseau, Corinne, additional, Zammit, Stefania Chetcuti, additional, Ellul, Pierre, additional, Eriksson, Carl, additional, Halfvarson, Jonas, additional, Magro, Fernando Jose, additional, Duricova, Dana, additional, Bortlik, Martin, additional, Fernandez, Alberto, additional, Hernández, Vicent, additional, Myers, Sally, additional, Sebastian, Shaji, additional, Oksanen, Pia, additional, Collin, Pekka, additional, Goldis, Adrian, additional, Misra, Ravi, additional, Arebi, Naila, additional, Kaimakliotis, Ioannis P, additional, Nikuina, Inna, additional, Belousova, Elena, additional, Brinar, Marko, additional, Cukovic-Cavka, Silvija, additional, Langholz, Ebbe, additional, and Munkholm, Pia, additional

Published
2018
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17. Survival in Crohn's disease-associated small bowel adenocarcinoma.

Author

Giuffrida, Paolo, Vanoli, Alessandro, Di Sabatino, Antonio, Axelrad, Jordan E., Olén, Ola, Sachs, Michael C., Erichsen, Rune, Pedersen, Lars, Halfvarson, Jonas, Askling, Johan, Ekbom, Anders, Sørensen, Henrik Toft, and Ludvigsson, Jonas F.

Subjects
SMALL intestine cancer, CROHN'S disease, INFLAMMATORY bowel diseases, MEDICAL sciences
Published
2021
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18. Development of an index to define overall disease severity in IBD

Author

Siegel, Corey A, primary, Whitman, Cynthia B, additional, Spiegel, Brennan M R, additional, Feagan, Brian, additional, Sands, Bruce, additional, Loftus, Edward V, additional, Panaccione, Remo, additional, D'Haens, Geert, additional, Bernstein, Charles N, additional, Gearry, Richard, additional, Ng, Siew C, additional, Mantzaris, Gerassimos J, additional, Sartor, Balfour, additional, Silverberg, Mark S, additional, Riddell, Robert, additional, Koutroubakis, Ioannis E, additional, O'Morain, Colm, additional, Lakatos, Peter L, additional, McGovern, Dermot P B, additional, Halfvarson, Jonas, additional, Reinisch, Walter, additional, Rogler, Gerhard, additional, Kruis, Wolfgang, additional, Tysk, Curt, additional, Schreiber, Stefan, additional, Danese, Silvio, additional, Sandborn, William, additional, Griffiths, Anne, additional, Moum, Bjorn, additional, Gasche, Christoph, additional, Pallone, Francesco, additional, Travis, Simon, additional, Panes, Julian, additional, Colombel, Jean-Frederic, additional, Hanauer, Stephen, additional, and Peyrin-Biroulet, Laurent, additional

Published
2016
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19. Natural disease course of Crohn’s disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study

Author

Burisch, Johan, Kiudelis, Gediminas, Kupcinskas, Limas, Kievit, Hendrika Adriana Linda, Andersen, Karina Winther, Andersen, Vibeke, Salupere, Riina, Pedersen, Natalia, Kjeldsen, Jens, D’Incà, Renata, Valpiani, Daniela, Schwartz, Doron, Odes, Selwyn, Olsen, Jóngerð, Nielsen, Kári Rubek, Vegh, Zsuzsanna, Lakatos, Peter Laszlo, Toca, Alina, Turcan, Svetlana, Katsanos, Konstantinos H, Christodoulou, Dimitrios K, Fumery, Mathurin, Gower-Rousseau, Corinne, Zammit, Stefania Chetcuti, Ellul, Pierre, Eriksson, Carl, Halfvarson, Jonas, Magro, Fernando Jose, Duricova, Dana, Bortlik, Martin, Fernandez, Alberto, Hernández, Vicent, Myers, Sally, Sebastian, Shaji, Oksanen, Pia, Collin, Pekka, Goldis, Adrian, Misra, Ravi, Arebi, Naila, Kaimakliotis, Ioannis P, Nikuina, Inna, Belousova, Elena, Brinar, Marko, Cukovic-Cavka, Silvija, Langholz, Ebbe, and Munkholm, Pia

Abstract

ObjectiveThe Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).ConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.

Published
2019
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20. Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study

Author

O¨rtqvist, Anne K, Lundholm, Cecilia, Halfvarson, Jonas, Ludvigsson, Jonas F, and Almqvist, Catarina

Abstract

ObjectiveEarlier studies on antibiotics exposure and development of IBD (Crohn’s disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD.DesignIn this cohort study of 827 239 children born in Sweden between 2006 and 2013, we examined the link between exposure to systemic antibiotics and VEO-IBD (diagnosis <6 years of age), using Cox proportional hazard regression models. Information on antibiotics and IBD was retrieved from the nationwide population-based Swedish Prescribed Drug Register and the National Patient Register. We specifically examined potential confounding from parental IBD and gastroenteritis.ResultsChildren exposed to antibiotics during pregnancy were at increased risk of IBD compared with general population controls (adjusted HR (aHR) 1.93; 95% CI 1.06 to 3.50). Corresponding aHRs were 2.48 (95% CI 1.01 to 6.08) for CD and 1.25 (95% CI 0.47 to 3.26) for UC, respectively. For antibiotics in infantile age, the aHR for IBD was 1.11 (95% CI 0.57 to 2.15); for CD 0.72 (95% CI 0.27 to 1.92) and 1.23 (95% CI 0.45 to 3.39) for UC. Excluding children with gastroenteritis 12 months prior to the first IBD diagnosis retained similar aHR for antibiotics during pregnancy and CD, while the association no longer remained significant for IBD.ConclusionWe found that exposure to antibiotics during pregnancy, but not in infantile age, is associated with an increased risk of VEO-IBD regardless of gastroenteritis. The risk increase for exposure in pregnancy may be due to changes in the microbiota.

Published
2019
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21. Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis

Author

Westerlind, Helga, primary, Mellander, Marie-Rose, additional, Bresso, Francesca, additional, Munch, Andreas, additional, Bonfiglio, Ferdinando, additional, Assadi, Ghazaleh, additional, Rafter, Joseph, additional, Hübenthal, Matthias, additional, Lieb, Wolfgang, additional, Källberg, Henrik, additional, Brynedal, Boel, additional, Padyukov, Leonid, additional, Halfvarson, Jonas, additional, Törkvist, Leif, additional, Bjork, Jan, additional, Andreasson, Anna, additional, Agreus, Lars, additional, Almer, Sven, additional, Miehlke, Stephan, additional, Madisch, Ahmed, additional, Ohlsson, Bodil, additional, Löfberg, Robert, additional, Hultcrantz, Rolf, additional, Franke, Andre, additional, and D'Amato, Mauro, additional

Published
2015
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22. Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

Author

Westerlind, Helga, Mellander, Marie-Rose, Bresso, Francesca, Munch, Andreas, Bonfiglio, Ferdinando, Assadi, Ghazaleh, Rafter, Joseph, Hübenthal, Matthias, Lieb, Wolfgang, Källberg, Henrik, Brynedal, Boel, Padyukov, Leonid, Halfvarson, Jonas, Törkvist, Leif, Bjork, Jan, Andreasson, Anna, Agreus, Lars, Almer, Sven, Miehlke, Stephan, and Madisch, Ahmed

Subjects
COLITIS, LOCUS in human genetics, SINGLE nucleotide polymorphisms, HUMAN leucocytes, LOGISTIC regression analysis, DISEASE risk factors
Published
2017
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23. Genetic variants inCDC42andNXPH1as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Author

Wouters, Mira M, primary, Lambrechts, Diether, additional, Knapp, Michael, additional, Cleynen, Isabelle, additional, Whorwell, Peter, additional, Agréus, Lars, additional, Dlugosz, Aldona, additional, Schmidt, Peter Thelin, additional, Halfvarson, Jonas, additional, Simrén, Magnus, additional, Ohlsson, Bodil, additional, Karling, Pontus, additional, Van Wanrooy, Sander, additional, Mondelaers, Stéphanie, additional, Vermeire, Severine, additional, Lindberg, Greger, additional, Spiller, Robin, additional, Dukes, George, additional, D'Amato, Mauro, additional, and Boeckxstaens, Guy, additional

Published
2013
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