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5 results on '"Palaniyappan, Naaventhan"'

1. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Author

Mózes, Ferenc Emil, primary, Lee, Jenny A, additional, Selvaraj, Emmanuel Anandraj, additional, Jayaswal, Arjun Narayan Ajmer, additional, Trauner, Michael, additional, Boursier, Jerome, additional, Fournier, Céline, additional, Staufer, Katharina, additional, Stauber, Rudolf E, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Gaia, Silvia, additional, Lupșor-Platon, Monica, additional, Petta, Salvatore, additional, Shima, Toshihide, additional, Okanoue, Takeshi, additional, Mahadeva, Sanjiv, additional, Chan, Wah-Kheong, additional, Eddowes, Peter J, additional, Hirschfield, Gideon M, additional, Newsome, Philip Noel, additional, Wong, Vincent Wai-Sun, additional, de Ledinghen, Victor, additional, Fan, Jiangao, additional, Shen, Feng, additional, Cobbold, Jeremy F, additional, Sumida, Yoshio, additional, Okajima, Akira, additional, Schattenberg, Jörn M, additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Wiegand, Johannes, additional, Karlas, Thomas, additional, Yılmaz, Yusuf, additional, Aithal, Guruprasad Padur, additional, Palaniyappan, Naaventhan, additional, Cassinotto, Christophe, additional, Aggarwal, Sandeep, additional, Garg, Harshit, additional, Ooi, Geraldine J, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Ziol, Marianne, additional, Barget, Nathalie, additional, Geier, Andreas, additional, Tuthill, Theresa, additional, Brosnan, M. Julia, additional, Anstee, Quentin Mark, additional, Neubauer, Stefan, additional, Harrison, Stephen A., additional, Bossuyt, Patrick M, additional, and Pavlides, Michael, additional

Published
2021
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3. Guidelines on the management of ascites in cirrhosis

Author

Aithal, Guruprasad P, primary, Palaniyappan, Naaventhan, additional, China, Louise, additional, Härmälä, Suvi, additional, Macken, Lucia, additional, Ryan, Jennifer M, additional, Wilkes, Emilie A, additional, Moore, Kevin, additional, Leithead, Joanna A, additional, Hayes, Peter C, additional, O'Brien, Alastair J, additional, and Verma, Sumita, additional

Published
2020
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4. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Author

Mózes, Ferenc Emil, Lee, Jenny A, Selvaraj, Emmanuel Anandraj, Jayaswal, Arjun Narayan Ajmer, Trauner, Michael, Boursier, Jerome, Fournier, Céline, Staufer, Katharina, Stauber, Rudolf E, Bugianesi, Elisabetta, Younes, Ramy, Gaia, Silvia, Lupsor-Platon, Monica, Petta, Salvatore, Shima, Toshihide, Okanoue, Takeshi, Mahadeva, Sanjiv, Chan, Wah-Kheong, Eddowes, Peter J, Hirschfield, Gideon M, Newsome, Philip Noel, Wong, Vincent Wai-Sun, de Ledinghen, Victor, Fan, Jiangao, Shen, Feng, Cobbold, Jeremy F, Sumida, Yoshio, Okajima, Akira, Schattenberg, Jo¨rn M, Labenz, Christian, Kim, Won, Lee, Myoung Seok, Wiegand, Johannes, Karlas, Thomas, Yılmaz, Yusuf, Aithal, Guruprasad Padur, Palaniyappan, Naaventhan, Cassinotto, Christophe, Aggarwal, Sandeep, Garg, Harshit, Ooi, Geraldine J, Nakajima, Atsushi, Yoneda, Masato, Ziol, Marianne, Barget, Nathalie, Geier, Andreas, Tuthill, Theresa, Brosnan, M. Julia, Anstee, Quentin Mark, Neubauer, Stefan, Harrison, Stephen A., Bossuyt, Patrick M, and Pavlides, Michael

Abstract

ObjectiveLiver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies.DesignIndividual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were calculated. Biomarkers were assessed individually and in sequential combinations.ResultsData were included from 37 primary studies (n=5735; 45% women; median age: 54 years; median body mass index: 30 kg/m2; 33% had type 2 diabetes; 30% had advanced fibrosis). AUROCs of individual LSM-VCTE, FIB-4 and NFS for advanced fibrosis were 0.85, 0.76 and 0.73. Sequential combination of FIB-4 cut-offs (<1.3; ≥2.67) followed by LSM-VCTE cut-offs (<8.0; ≥10.0 kPa) to rule-in or rule-out advanced fibrosis had sensitivity and specificity (95% CI) of 66% (63–68) and 86% (84–87) with 33% needing a biopsy to establish a final diagnosis. FIB-4 cut-offs (<1.3; ≥3.48) followed by LSM cut-offs (<8.0; ≥20.0 kPa) to rule out advanced fibrosis or rule in cirrhosis had a sensitivity of 38% (37–39) and specificity of 90% (89–91) with 19% needing biopsy.ConclusionSequential combinations of markers with a lower cut-off to rule-out advanced fibrosis and a higher cut-off to rule-in cirrhosis can reduce the need for liver biopsies.

Published
2022
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5. Guidelines on the management of ascites in cirrhosis.

Author

Aithal, Guruprasad P., Palaniyappan, Naaventhan, China, Louise, Härmälä, Suvi, Macken, Lucia, Ryan, Jennifer M., Wilkes, Emilie A., Moore, Kevin, Leithead, Joanna A., Hayes, Peter C., O'Brien, Alastair J., and Verma, Sumita

Subjects
HYPONATREMIA, HEPATORENAL syndrome, FATTY liver, ASCITES, RENIN-angiotensin system, CIRRHOSIS of the liver
Published
2021
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