1. Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial
- Author
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Lucas Wauters, Luka Van Oudenhove, Alison Accarie, Karlien Geboers, Hannelore Geysen, Joran Toth, Anja Luypaerts, Kristin Verbeke, Tamara Smokvina, Jeroen Raes, Jan Tack, and Tim Vanuytsel
- Subjects
lactobacillus rhamnosus ,probiotic ,permeability ,stress ,gut-brain interaction ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Psychological stress negatively affects the intestinal barrier function in animals and humans. We aimed to study the effect of Lactobacillus rhamnosus CNCM I-3690 on intestinal permeability and stress-markers during public speech. Healthy students were randomized to L. rhamnosus-containing (test) or acidified (placebo) milk consumed twice daily for 4 weeks, with 46 subjects per treatment group. Small intestinal permeability was quantified by a 2 h urinary lactulose–mannitol ratio (LMR, primary outcome), fractional excretion of lactulose (FEL) and mannitol (FEM). Salivary cortisol, State-Trait Anxiety Inventory (STAI) and Perceived Stress scores (PSS) were collected. No between-treatment differences were found for LMR (p = .71), FEL or FEM. Within-treatment analyses showed similar LMR and FEL but a stress-induced increase of FEM with the placebo (p
- Published
- 2022
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