1. Preoperative 18F-Fluorodeoxyglucose Positron Emission Tomography/CT in Prediction of Uterine Risk Factors and Lymph Node Metastasis: An Analysis of 111 Endometrioid Endometrial Cancer Patients
- Author
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Salih Taşkın, Cigdem Soydal, Fırat Ortaç, Kazibe Koyuncu, Bahar Konuralp Atakul, Alper Kahraman, Erkan Ibis, and Yavuz Emre Şükür
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Lymph node metastasis ,Risk Assessment ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Fluorodeoxyglucose positron emission tomography ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Predictive Value of Tests ,Risk Factors ,Positron Emission Tomography Computed Tomography ,medicine ,Humans ,Prospective Studies ,Lymph node ,Aged ,PET-CT ,medicine.diagnostic_test ,business.industry ,Endometrial cancer ,Obstetrics and Gynecology ,Histology ,Middle Aged ,medicine.disease ,Endometrial Neoplasms ,medicine.anatomical_structure ,Reproductive Medicine ,Positron emission tomography ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Preoperative Period ,Myometrium ,Female ,Lymphadenectomy ,Lymph Nodes ,Radiology ,Radiopharmaceuticals ,business ,Carcinoma, Endometrioid - Abstract
Introduction: This study evaluated the role of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) in the detection of lymph node metastases and the association between uterine maximum standardized uptake values (SUVmax) and the histopathological features in endometrial cancer patients. Materials and Methods: Patients with endometrioid endometrial cancer underwent preoperative 18F-FDG PET/CT imaging and were staged surgically. 18F-FDG PET/CT findings were compared with final pathology reports. Grade 3 histology or grade 2 histology with myometrial invasion ≥50% was established as a high risk feature. Results: One hundred and eleven patients were analysed. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of 18F-FDG PET/CT in the detection of lymph node metastasis in all patients (n = 111) were 67, 96, 93, 60 and 97%, respectively. In the high-risk group, sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT were 75, 92, 91, 60 and 96%, respectively. Uterine SUVmax was found to be associated with myometrial invasion, grade and cervical stromal involvement. Conclusions:18F-FDG PET/CT has limited sensitivity and accuracy in detecting lymph node metastasis. Therefore, as of now, it is not accepted as a modality that can replace lymphadenectomy. SUVmax values can predict high-risk factors.
- Published
- 2016
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