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Your search keyword '"Park, Sang-Yoon"' showing total 41 results
Start Over Author "Park, Sang-Yoon" Journal gynecologic oncology
41 results on '"Park, Sang-Yoon"'

8. BRCA1/2 mutations associated with progression-free survival in ovarian cancer patients in the AGO-OVAR 16 study

Author

Harter, Philipp, Johnson, Toby, Berton-Rigaud, Dominique, Park, Sang-Yoon, Friedlander, Michael, del Campo, Josep M., Shimada, Muneaki, Forget, Frédéric, Mirza, Mansoor R., Colombo, Nicoletta, Zamagni, Claudio, Chan, John K., Imhof, Martin, Herzog, Thomas J., O'Donnell, Dearbhaile, Heitz, Florian, King, Karen, Stinnett, Sandy, Barrett, Catherine, Jobanputra, Minesh, Xu, Chun-Fang, and du Bois, Andreas

Published
2016
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40. Risk factors predicting residual disease in subsequent hysterectomy following conization for cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer

Author

Park, Jeong-Yeol, Seung Mi Lee, Chong Woo Yoo, Kang, Sokbom, Park, Sang-Yoon, and Seo, Sang-Soo

Subjects
*PAPILLOMAVIRUSES, *CANCER patients, *WOMEN'S health, *MATHEMATICAL statistics
Abstract

Abstract: Objective. : To determine factors predicting post-cone residual disease in cervical intraepithelial neoplasia (CIN) III and microinvasive cervical cancer. Methods. : Of 337 patients who underwent conization due to CIN III and microinvasive cervical cancer between November 2001 and March 2006, 77 underwent hysterectomy within 6 months of conization. We analyzed their demographic features, pathologic parameters and pre-cone high-risk human papilloma virus (HR-HPV) load measured by Digene Hybrid Capture II. Results. : In univariate analysis, age ≥50 years (P =0.048, relative risk [RR]=2.74, 95% confidence interval [CI]=1.0–7.4), positive resection margin (P =0.004, RR=4.35, 95% CI=1.5–12.3), and pre-cone HR-HPV load ≥300 relative light units (RLU)/positive control (PC) (P =0.009, RR=3.41, 95% CI=1.3–8.7) were significant factors associated with residual disease. While postmenopausal status showed borderline significance (P =0.065, RR=2.65, 95% CI=0.9–7.5), parity ≥3, severity of disease (CIN III vs. microinvasive cancer), conization method (large loop excision of transformation zone vs. cold knife conization), and glandular extension were not significant. In multivariate analysis only positive margin (P =0.023, RR=3.56, 95% CI=1.2–10.7) and pre-cone HR-HPV load ≥300 RLU/PC (P =0.034, RR=2.96, 95% CI=1.1–8.1) were significant factors associated with residual disease. Conclusion. : Positive margin and pre-cone HR-HPV load ≥300 RLU/PC were the only significant factors predicting post-cone residual disease in multivariate analysis. Appropriate application of these predictive factors may avoid post-cone hysterectomy. [Copyright &y& Elsevier]

Published
2007
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41. Pretreatment laparoscopic surgical staging in locally advanced cervical cancer: preliminary results in Korea.

Author

Chung HH, Lee S, Sim JS, Kim JY, Seo SS, Park SY, and Roh JW

Subjects
Adult, Aged, Combined Modality Therapy, Female, Humans, Laparoscopy, Magnetic Resonance Imaging, Middle Aged, Neoplasm Staging, Uterine Cervical Neoplasms drug therapy, Uterine Cervical Neoplasms radiotherapy, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms surgery
Abstract

Objectives: The purpose of this study was to evaluate the feasibility and efficacy of pretreatment laparoscopic surgical staging in the treatment of locally advanced cervical cancer., Methods: Forty-four patients with locally advanced cervical cancer who underwent pretreatment laparoscopic surgical staging between October 2001 and April 2004 were reviewed. The pathological diagnosis after laparoscopic surgical staging was compared with results from preoperative magnetic resonance imaging (MRI), and surgical results with follow-up data were evaluated., Results: The mean duration of surgery was 202.0 (range: 120-300) min and the mean number of harvested lymph nodes (LNs) was 38.7 (range: 20-75). Twenty (45.5%) patients had pelvic LN metastasis and 5 (11.4%) patients had pelvic and para-aortic LN metastasis. Region-specific findings of MRI resulted in sensitivity and positive predictive values of 55.9% and 48.7%, respectively, on a three-region analysis. When compared with MRI, laparoscopic surgical staging was superior in detecting microscopic LN metastasis. The time to commencing concurrent chemoradiotherapy after laparoscopic surgical staging was 8.6 +/- 3.3 (mean +/- SD) days. All the patients received concurrent chemoradiotherapy as scheduled. There were three (6.8%) cases of minor postoperative complications, and no mortality occurred during the follow-up period. The 2-year disease-free survival rate of the current study was 89.7%, and three (6.8%) patients experienced recurrence after treatment., Conclusions: Laparoscopic surgical staging in locally advanced cervical cancer is a feasible and safe pretreatment method, and can be used as a best guideline for individualized concurrent chemoradiotherapy.

Published
2005
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